Long-Term Follow-Up of Thyroid Incidentalomas Visualized with 18F-Fluorodeoxyglucose Positron Emission Tomography—Impact of Thyroid Scintigraphy in the Diagnostic Work-Up

Korsholm, Kirsten; Reichkendler, Michala Holm; Alslev, Louise; Rasmussen, Åse Krogh; Oturai, Peter

doi:10.3390/diagnostics11030557

Cited by 1 publication

(1 citation statement)

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“…Thus, the best treatment opportunity is often missed, even when clinical symptoms appear, impacting patient prognosis. Many studies have demonstrated that thyroid scintigraphy is an effective method for differentiating Graves’ disease, thyroiditis, and thyroid tumors ( 7 , 8 ). In addition, the interpretation of thyroid scintigraphy findings relies heavily on the expertise of nuclear medicine physicians.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of thyroid disease using deep convolutional neural network models applied to thyroid scintigraphy images: a multicenter study

Zhao,

Zheng,

Zhang

et al. 2023

Front. Endocrinol.

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ObjectivesThe aim of this study was to improve the diagnostic performance of nuclear medicine physicians using a deep convolutional neural network (DCNN) model and validate the results with two multicenter datasets for thyroid disease by analyzing clinical single-photon emission computed tomography (SPECT) image data.MethodsIn this multicenter retrospective study, 3194 SPECT thyroid images were collected for model training (n=2067), internal validation (n=514) and external validation (n=613). First, four pretrained DCNN models (AlexNet, ShuffleNetV2, MobileNetV3 and ResNet-34) for were tested multiple medical image classification of thyroid disease types (i.e., Graves’ disease, subacute thyroiditis, thyroid tumor and normal thyroid). The best performing model was then subjected to fivefold cross-validation to further assess its performance, and the diagnostic performance of this model was compared with that of junior and senior nuclear medicine physicians. Finally, class-specific attentional regions were visualized with attention heatmaps using gradient-weighted class activation mapping.ResultsEach of the four pretrained neural networks attained an overall accuracy of more than 0.85 for the classification of SPECT thyroid images. The improved ResNet-34 model performed best, with an accuracy of 0.944. For the internal validation set, the ResNet-34 model showed higher accuracy (p < 0.001) when compared to that of the senior nuclear medicine physician, with an improvement of nearly 10%. Our model achieved an overall accuracy of 0.931 for the external dataset, a significantly higher accuracy than that of the senior physician (0.931 vs. 0.868, p < 0.001).ConclusionThe DCNN-based model performed well in terms of diagnosing thyroid scintillation images. The DCNN model showed higher sensitivity and greater specificity in identifying Graves’ disease, subacute thyroiditis, and thyroid tumors compared to those of nuclear medicine physicians, illustrating the feasibility of deep learning models to improve the diagnostic efficiency for assisting clinicians.

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Section: Introductionmentioning

confidence: 99%