Long‐Term Follow‐Up of Renal Function in Dogs after Treatment for<scp>ACTH</scp>‐Dependent Hyperadrenocorticism

Smets, Pascale; Lefebvre, Henri; Meij, Björn P.; Croubels, Siska; Meyer, Evelyne; Maele, Isabel Van de; Daminet, Sylvie

doi:10.1111/j.1939-1676.2012.00915.x

Cited by 42 publications

(61 citation statements)

References 62 publications

(121 reference statements)

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“…Although hepatic biopsies were not obtained, 90% (18/20) of the dogs in this study had increased ALP activities. Because glomerular filtration rate is increased in dogs with HAC,18 alterations in renal clearance are unlikely to have affected results of this study.…”

Section: Discussionmentioning

confidence: 94%

Canine Pancreatic‐Specific Lipase Concentrations in Clinically Healthy Dogs and Dogs with Naturally Occurring Hyperadrenocorticism

Mawby

Whittemore

Fecteau

2014

Veterinary Internal Medicne

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BackgroundSpecificity of canine pancreatic lipase immunoreactivity (cPLI) assays in dogs with hyperadrenocorticism (HAC) is unknown.HypothesisResults of cPLI assays differ for clinically healthy dogs and dogs with HAC.AnimalsSeventeen healthy dogs and 20 dogs with HAC diagnosed by ACTH stimulation test results without evidence of clinical pancreatitis.MethodsDogs were enrolled between December 2009 and November 2010. Serum cPLI concentrations were determined by quantitative (Spec cPL test, SPEC) and semiquantitative (SNAP cPL test, SNAP) assays. Results were categorized as normal, equivocal, or abnormal (SPEC) or negative or positive (SNAP). Associations between group and cPLI were assessed using Fisher's exact test or the Mann–Whitney U‐test. Spearman rank correlation coefficients (ρ) were determined for SNAP and SPEC results. Significance was set at P < .05.ResultsSpec cPL test concentrations were significantly (P < .001) higher in dogs with HAC (491.1 μg/L) than in healthy dogs (75.2 μg/L), with more abnormal SPEC results in HAC dogs (P < .001). There were more (P = .002) positive SNAP results in dogs with HAC (55%) than in healthy dogs (6%). SNAP and SPEC results were highly correlated (ρ = 0.85; P < .001).Conclusions and Clinical ImportanceDogs with HAC had higher SPEC concentrations and more positive SNAP results than clinically healthy dogs with normal ACTH stimulation test results. Specificity of SPEC and SNAP assays in HAC dogs without clinical pancreatitis were 65 and 45%, respectively. Pending further study, SNAP and SPEC results should be interpreted cautiously in dogs with HAC to avoid false diagnosis of concurrent pancreatitis.

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Section: Discussionmentioning

confidence: 94%

Canine Pancreatic‐Specific Lipase Concentrations in Clinically Healthy Dogs and Dogs with Naturally Occurring Hyperadrenocorticism

Mawby

Whittemore

Fecteau

2014

Veterinary Internal Medicne

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“…Based on our results proteinuria did not seem to influence the survival time in the study population. In proteinuric PDH dogs in one recent report, normalisation or a significant reduction in UPC was observed in most cases subsequently treated with trilostane or hypophysectomy (Smets and others 2012); this phenomenon might prevent the progression of renal injury induced by proteinuria. Furthermore, deaths related to renal diseases were uncommon in this study as in previous similar studies (Barker and others 2005, Perez-Alenza and others 2006, Clemente and others 2007).…”

Section: Discussionmentioning

confidence: 96%

Prognostic factors for survival in dogs with pituitary‐dependent hypercortisolism treated with trilostane

et al. 2015

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Pituitary-dependent hypercortisolism (PDH) is one of the most frequent endocrinopathies in dogs, but prognostic factors are largely unknown. The aim of this retrospective case series study was to determine the prognostic value of different clinical and clinicopathological variables evaluated in dogs newly diagnosed with PDH that were subsequently treated with trilostane. Medical records from one referral centre were evaluated. Eighty-five dogs with PDH were included. The median survival time was 852 days (range 2-3210 days); 60/85 (70 per cent) and 25/85 (29 per cent) dogs survived more than one and three years, respectively. In multivariable model analysis the length of survival of older dogs (HR 1.24, 95% CI 1.09 to 1.40) and dogs with higher serum phosphate concentrations (HR 1.35, 95% CI 1.01 to 1.81) was shorter. Serum phosphate concentrations were above the reference range in 37/85 (44 per cent) of animals. Clinical signs, liver enzymes, serum cortisol concentrations of the endocrine tests, proteinuria, systolic hypertension, the presence of concomitant disorders, and the frequency of trilostane administration were not associated with survival time. Hyperphosphataemia is a common finding in dogs with newly diagnosed PDH and represents a negative prognostic factor.

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“…Similarly, veterinary care causes stress in dogs and increases their urine cortisol:creatinine ratio (UCCr) while IH compared to AH . Both naturally occurring and iatrogenic hypercortisolemia have resulted in increased UPC in dogs …”

Section: Introductionmentioning

confidence: 99%

Urine cortisol‐creatinine and protein‐creatinine ratios in urine samples from healthy dogs collected at home and in hospital

Citron¹,

Weinstein

Littman

et al. 2020

Veterinary Internal Medicne

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Background Recently, urine protein:creatinine ratios (UPC) were shown to be lower in urine samples from dogs collected at home (AH) as compared to those collected in hospital (IH). Stress‐inducing procedures and travel to the hospital have been hypothesized to cause prerenal proteinuria. Objectives Evaluate patient stress using urine cortisol:creatinine ratios (UCCr) and correlate UCCr to UPC in urine samples obtained AH and IH. Animals Thirty‐six healthy, client‐owned dogs. Methods Prospective, non‐masked study. Two voided urine samples were obtained (AH and IH). Complete urinalysis as well as UPC and UCCr were performed. Clients graded their dogs' stress level AH, in transport, and IH. Results The UCCr was significantly higher in IH samples than in AH samples (P < .0001), but UPC was not significantly different between AH and IH urine samples (P = .14). In all samples and in both collection settings, UCCr was not significantly correlated with UPC. Travel time and time IH were not correlated with change in UCCr or UPC. In 8 dogs with borderline or overt proteinuria, no significant difference was found in UPC between settings, but UCCr was significantly higher in IH samples. Conclusions and Clinical Importance The UPC was not higher when measured in urine samples collected IH compared to AH. Dogs had higher UCCr IH, but UCCr was not associated with UPC. Stress, as estimated by UCCr, did not affect proteinuria. Further evidence is needed to support the claim that stress may result in proteinuria in healthy dogs.

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Long‐Term Follow‐Up of Renal Function in Dogs after Treatment forACTH‐Dependent Hyperadrenocorticism

Abstract: A decrease in GFR and persistent proteinuria post-treatment may warrant the clinician's attention. Future research including renal histopathology of dogs with persistent proteinuria or low GFR is needed to further assess renal outcome.

Cited by 42 publications

References 62 publications

Canine Pancreatic‐Specific Lipase Concentrations in Clinically Healthy Dogs and Dogs with Naturally Occurring Hyperadrenocorticism

Canine Pancreatic‐Specific Lipase Concentrations in Clinically Healthy Dogs and Dogs with Naturally Occurring Hyperadrenocorticism

Prognostic factors for survival in dogs with pituitary‐dependent hypercortisolism treated with trilostane

Urine cortisol‐creatinine and protein‐creatinine ratios in urine samples from healthy dogs collected at home and in hospital

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