Long-term follow-up of photodynamic therapy with a self-adhesive 5-aminolaevulinic acid patch: 12 months data

Szeimies, Rolf‐Markus; Stockfleth, Eggert; Popp, Georg; Borrosch, F.; Brüning, H.; Dominicus, R.; Mensing, H.; Reinhold, Uwe; Reich, Kristian; Moor, Anne C.E.; Stocker, Marcus; Ortland, C.; Brunnert, Marcus; Hauschild, Axel

doi:10.1111/j.1365-2133.2009.09377.x

Cited by 65 publications

(66 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, the long-term efficacy of AK peaked at 3 months and then decreased gradually. Our results were consistent with those of a previous long-term follow-up study31.…”

Section: Discussionsupporting

confidence: 93%

Comparative Study of Photodynamic Therapy with Topical Methyl Aminolevulinate versus 5-Aminolevulinic Acid for Facial Actinic Keratosis with Long-Term Follow-Up

Kim

Song

2014

Ann Dermatol

View full text Add to dashboard Cite

BackgroundFew studies have compared the efficacy, cosmetic outcomes, and adverse events between 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and methyl aminolevulinate-PDT (MAL-PDT) for actinic keratoses (AKs) in Asian ethnic populations with dark-skin.ObjectiveWe retrospectively compared the long-term efficacy, recurrence rates, cosmetic outcomes, and safety of ALA-PDT versus MAL-PDT for facial AKs in Koreans.MethodsA total of 222 facial AKs in 58 patients were included in this study. A total of 153 lesions (29 patients) were treated with 5-ALA, and 69 lesions (29 patients) with MAL. ALA and MAL creams were applied for 6 hours and 3 hours, respectively; the lesions were then illuminated with a halogen lamp at 150 J/cm2 for ALA-PDT and a diode lamp at 37 J/cm2 for MAL-PDT.ResultsThe complete response rates of ALA-PDT and MAL-PDT were 56.9% and 50.7%, respectively, with no significant difference at 12 months after treatment. No significant difference in recurrence rates was observed between the 2 PDT modalities at either 6 or 12 months after treatment. There was no significant difference in the cosmetic outcomes between the 2 treatment modalities at 12 months after PDT. However, ALA-PDT caused significantly more painful than MAL-PDT (p=0.005). The adverse events were mild to moderate, transient, and self-limiting for both modalities.ConclusionMAL-PDT was similar to ALA-PDT in terms of long-term efficacy, recurrence rates, cosmetic outcomes, and adverse events; however, it was a significantly less painful procedure than ALA-PDT in our study.

show abstract

“…In this study, the long-term efficacy of AK peaked at 3 months and then decreased gradually. Our results were consistent with those of a previous long-term follow-up study31.…”

Section: Discussionsupporting

confidence: 93%

Comparative Study of Photodynamic Therapy with Topical Methyl Aminolevulinate versus 5-Aminolevulinic Acid for Facial Actinic Keratosis with Long-Term Follow-Up

Kim

Song

2014

Ann Dermatol

View full text Add to dashboard Cite

show abstract

“…129-130 Current studies focus on novel photosensitizer drugs and re-formulations of ALA, such as nanoemulsion or patch based applicators, that may increase the complete response rate for AK at 12 months to >95%. 131 The results of ALA-PDT in the treatment of Bowen’s disease (squamous cell carcinoma in situ ) have been equally positive and so far were reported in 6 randomized clinical trials. Randomized, controlled trials comparing ALA-PDT or MAL-PDT to cryotherapy or 5-FU cream reveal complete response rates of 82-100% for PDT vs 67-100% for cryotherapy or 79-94% for 5-FU at 12-24 months.…”

Section: Clinical Pdtmentioning

confidence: 96%

Photodynamic therapy of cancer: An update

Agostinis

Berg

Cengel

et al. 2011

CA: A Cancer Journal for Clinicians

4,073

3,792

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative particularly in early-stage tumors. It can prolong survival in inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.

show abstract

“…12,25 A significant aspect of AK therapy is the recurrence of lesions, with reported recurrence rates following cryosurgery varying greatly (1.2-79.0%) across studies, depending on the length of the follow-up and the severity of the lesions. 8,10,[26][27][28] In our study, patients treated with 0.5% 5-FU/SA solution once-daily had a > 2-fold lower incidence of lesion recurrence during the study than patients who received cryosurgery (39.4% vs. 84.8%, respectively; P = 0.0001). Cryosurgery is frequently used for treating isolated, visible AKs; however, unlike field-directed topical therapies, it does not treat perilesional skin, which might account for high recurrence rates.…”

Section: Discussionmentioning

confidence: 89%

A prospective randomized exploratory study comparing the efficacy of once‐daily topical 0.5% 5‐fluorouracil in combination with 10.0% salicylic acid (5‐FU/SA) vs. cryosurgery for the treatment of hyperkeratotic actinic keratosis

Simon

Dominicus

Karl³

et al. 2014

Acad Dermatol Venereol

Self Cite

View full text Add to dashboard Cite

A prospective randomized exploratory study comparing the efficacy of once-daily topical 0.5% 5-fluorouracil in combination with 10.0% salicylic acid (5-FU/SA) vs. cryosurgery for the treatment of hyperkeratotic actinic keratosis Mean change in lesion count from baseline to Day 98 was À5.2 and À5.7 lesions per patient for 0.5% 5-FU/SA and cryotherapy groups respectively. Histological AK clearance rates on Day 98 were 62.1% and 41.9% respectively. At 6-month posttreatment follow-up, recurrence of cleared lesions (no clinically visible lesions in treatment area) occurred in 39.4% of 0.5% 5-FU/SA and 84.8% of cryosurgery patients. Drug-related adverse events (AEs), including local skin reactions considered 'severe' by the investigator, were reported in 24.2% of 0.5% 5-FU/SA and 6.1% of cryosurgery patients. All drug-related AEs were skin reactions.Conclusions Although the study was not powered to explore statistical differences in clinical efficacy between treatments, a short (6-week) schedule of topical treatment with 0.5% 5-FU/SA achieved greater histological clearance and lower recurrence of grade II/III hyperkeratotic AKs than cryosurgery. AE incidence across both treatment groups was relatively low and AEs were generally mild or moderate. Clinical trials.gov identifier: NCT01358851.

show abstract

Long-term follow-up of photodynamic therapy with a self-adhesive 5-aminolaevulinic acid patch: 12 months data

Abstract: Twelve months after a single 5-ALA patch-PDT the majority of lesions were still cleared with an excellent cosmetic outcome. 5-ALA patch-PDT proved to be superior to cryosurgery in the noninferiority study setting.

Cited by 65 publications

References 18 publications

Comparative Study of Photodynamic Therapy with Topical Methyl Aminolevulinate versus 5-Aminolevulinic Acid for Facial Actinic Keratosis with Long-Term Follow-Up

Comparative Study of Photodynamic Therapy with Topical Methyl Aminolevulinate versus 5-Aminolevulinic Acid for Facial Actinic Keratosis with Long-Term Follow-Up

Photodynamic therapy of cancer: An update

A prospective randomized exploratory study comparing the efficacy of once‐daily topical 0.5% 5‐fluorouracil in combination with 10.0% salicylic acid (5‐FU/SA) vs. cryosurgery for the treatment of hyperkeratotic actinic keratosis

Contact Info

Product

Resources

About