Long-Term Follow-Up of Patients with Neck Pain Associated with Ossification of the Posterior Longitudinal Ligament Treated with Integrative Complementary and Alternative Medicine: A Retrospective Analysis and Questionnaire Survey

Namgoong, Jin; Lee, Yun-Ha; Ju, Ah Ra; Chai, Jiwon; Choi, DongJoo; Choi, Hyo Jung; Seo, Ji-Yeon; Park, Kyoung Sun; Lee, Yoon Jae; Lee, Jinho; Ha, In‐Hyuk

doi:10.2147/jpr.s356280

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Park et al [5] reported a case of acupotomy treatment, while Lee et al [4] reported a case of chuna therapy with other TKM treatments; both studies demonstrated reductions in VAS and NDI scores. A study by Namgoong et al [8], 78 OPLL patients who were treated with TKM during their hospital stay experienced a reduction in their NRS (numerical rating scale) and NDI scores, with further reductions in NRS and NDI scores experienced by most patients upon longterm follow-up. However, none of these studies used complex acupuncture treatment alone.…”

Section: Jar Discussionmentioning

confidence: 98%

Complex Acupuncture Treatment for Cervical Ossification of Posterior Longitudinal Ligament: Case Report of Two Patients

Kim,

Choi,

Woo

et al. 2023

J Acupunct Res

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Ossification of the posterior longitudinal ligament (OPLL) is a disease that narrows the spinal canal, causing neurological symptoms. To date, there have been several reports on traditional Korean medicine treatments for OPLL; however, there is no study on complex acupuncture treatment. Herein, we report 2 cases of cervical OPLL involving cervical pain, upper limb radiating pain, and hypoesthesia. The patients were diagnosed using C-spine computed tomography and did not receive any treatment at any other hospital. The patients were treated with acupuncture treatments, including electroacupuncture, pharmacopuncture, and acupotomy, at

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Section: Jar Discussionmentioning

confidence: 98%

Complex Acupuncture Treatment for Cervical Ossification of Posterior Longitudinal Ligament: Case Report of Two Patients

Kim,

Choi,

Woo

et al. 2023

J Acupunct Res

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“…In this study, we evaluated the therapeutic efficacy of the epidural application of Shinbaro2 (Sh2), a pharmacopuncture solution derived from , in a rat model of LSS. GCSB-5 is a composite formulation containing a blend of six distinct wild herbs, including Cibotium barometz, Bang-Poong (Saposhnikovia divaricata [Turcz] Schischkin), Eucommia ulmoides, and Ogapi (Acanthopanax sessiliflorum, Achyranthes japonica, and Glycine max) (Namgoong et al, 2022). This formulation has undergone standardization by the Korea Food and Drug Administration (KFDA), and is renowned for its multifaceted therapeutic properties, including anti-inflammatory, neuroprotective, cartilage regeneration, and analgesic effects (Kim et al, 2011;Kim et al, 2012;Ha et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Repeated epidural delivery of Shinbaro2: effects on neural recovery, inflammation, and pain modulation in a rat model of lumbar spinal stenosis

Hong,

Yeo,

Kim

et al. 2024

Front. Pharmacol.

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The choice of treatment for lumbar spinal stenosis (LSS) depends on symptom severity. When severe motor issues with urinary dysfunction are not present, conservative treatment is often considered to be the priority. One such conservative treatment is epidural injection, which is effective in alleviating inflammation and the pain caused by LSS-affected nerves. In this study, Shinbaro2 (Sh2), pharmacopuncture using natural herbal medicines for patients with disc diseases, is introduced as an epidural to treat LSS in a rat model. The treatment of primary sensory neurons from the rats’ dorsal root ganglion (DRG) neurons with Sh2 at various concentrations (0.5, 1, and 2 mg/mL) was found to be safe and non-toxic. Furthermore, it remarkably stimulated axonal outgrowth even under H2O2-treated conditions, indicating its potential for stimulating nerve regeneration. When LSS rats received epidural injections of two different concentrations of Sh2 (1 and 2 mg/kg) once daily for 4 weeks, a significant reduction was seen in ED1+ macrophages surrounding the silicone block used for LSS induction. Moreover, epidural injection of Sh2 in the DRG led to a significant suppression of pain-related factors. Notably, Sh2 treatment resulted in improved locomotor recovery, as evaluated by the Basso, Beattie, and Bresnahan scale and the horizontal ladder test. Additionally, hind paw hypersensitivity, assessed using the Von Frey test, was reduced, and normal gait was restored. Our findings demonstrate that epidural Sh2 injection not only reduced inflammation but also improved locomotor function and pain in LSS model rats. Thus, Sh2 delivery via epidural injection has potential as an effective treatment option for LSS.

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Ten-Year Follow-up of Posterior Decompression and Fusion Surgery for Thoracic Ossification of the Posterior Longitudinal Ligament

Ito,

Nakashima,

Segi

et al. 2024

Journal of Bone and Joint Surgery

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Background: We evaluated the clinical, functional, and quality of life (QoL) outcomes of surgical treatment of thoracic ossification of the posterior longitudinal ligament (T-OPLL). Methods: We retrospectively evaluated 51 patients followed for ≥10 years after posterior decompression and corrective fusion surgery for T-OPLL. The data collected included demographics, comorbidities, and pre- and postoperative symptoms. The Japanese Orthopaedic Association (JOA) score, numerical rating scale (NRS) for back and leg pain, and EuroQol-5 Dimension-5 Level (EQ-5D-5L) were used to assess neurological function, pain, and QoL. Imaging evaluations were conducted to assess changes in kyphotic angles and ossification progression. Results: A significant improvement was observed in the JOA score from preoperatively (3.7) to 2 years postoperatively (7.9) (p < 0.05); the score remained stable thereafter. The mean EQ-5D-5L score improved from 0.53 preoperatively to 0.68 at 10 years postoperatively (p < 0.001). NRS scores for back and leg pain decreased from 5.4 to 3.5 and 4.0 to 3.0, respectively, from preoperatively to 10 years (p < 0.001 for both). Radiographic outcomes showed changes in kyphotic angles and ossification areas, with no significant progression after 2 years. Fourteen (27.5%) of the patients experienced postoperative complications. Of these, 8 (15.7%) required reoperation, 6 (11.8%) in the perioperative period and 2 (3.9%) later. Four (7.8%) of the patients underwent additional surgeries for conditions including lumbar spinal canal stenosis and cervical OPLL. Nonetheless, physical function in all cases with postoperative complications or additional surgery remained stable over the decade. Conclusions: Surgical treatment of T-OPLL is effective in improving neurological function, QoL, and pain management over an extended period. The long-term outcomes of T-OPLL surgery revealed that, although cervical and lumbar spinal lesions led to reoperations, they did not affect QoL, and relative improvement was maintained even after 10 years. Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

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Long-Term Follow-Up of Patients with Neck Pain Associated with Ossification of the Posterior Longitudinal Ligament Treated with Integrative Complementary and Alternative Medicine: A Retrospective Analysis and Questionnaire Survey

Cited by 3 publications

References 40 publications

Complex Acupuncture Treatment for Cervical Ossification of Posterior Longitudinal Ligament: Case Report of Two Patients

Complex Acupuncture Treatment for Cervical Ossification of Posterior Longitudinal Ligament: Case Report of Two Patients

Repeated epidural delivery of Shinbaro2: effects on neural recovery, inflammation, and pain modulation in a rat model of lumbar spinal stenosis

Ten-Year Follow-up of Posterior Decompression and Fusion Surgery for Thoracic Ossification of the Posterior Longitudinal Ligament

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