Abstract:Long-term consequences were present for approximately 50% of the patients 3 years after mild traumatic brain injury and were also reported 11 years after mild traumatic brain injury. This needs to be taken into account by healthcare professionals and society in general when dealing with people who have undergone mild traumatic brain injury.
“…8 Longer-term studies suggest that symptoms may persist for up to 3 years after injury. 2,9,10 Further longitudinal studies are required, however, to improve understanding of the extent of difficulties experienced after mTBI and the recovery trajectory.…”
“…8 Longer-term studies suggest that symptoms may persist for up to 3 years after injury. 2,9,10 Further longitudinal studies are required, however, to improve understanding of the extent of difficulties experienced after mTBI and the recovery trajectory.…”
“…A scoring algorithm is used to convert the raw scores into the eight dimensions listed above, followed by the transformation of scores to a range of 0-100 (mean 50) with higher scores representing better health-related QoL. Using two summary scales (physical and mental), the SF-36 has demonstrated good reliability and validity for adults following mTBI (Ahman et al, 2013;Emanuelson, Andersson, Björklund, & Stålhammar, 2003). The scale is reliable, with established content and construct validity (Burholt & Nash, 2011) and was found to be internally consistent with a Cronbach alpha co-efficient of .88.…”
Section: Methodsmentioning
confidence: 98%
“…Affected individuals can experience transient, long-lasting or permanent physical, cognitive, behavioural, and emotional consequences. These include increased risk of depression, poor quality of life (QoL) (Lin et al, 2010), and the presence of post-concussion symptoms (PCS) (e.g., fatigue, headache, irritability, dizziness, concentration difficulties and impaired memory) (Cicerone Stålnacke, 2013;Stålnacke, 2012).…”
“…It is estimated that 70–90% of TBI cases is mild TBI (mTBI), which is defined by a Glasgow Coma Scale of 13 to 15. This includes those cases where the period of loss of consciousness is < 30 min and the period of post-traumatic amnesia is < 24 h (Ahman et al, 2013). Mild brain injury can have serious post-concussion symptoms including headache, fatigue, dizziness, poor memory, depression, irritability and concentration difficulties.…”
Cerebral venous oxygen saturation (SvO2) is an important biomarker of brain function. In this study, we aimed to explore the relative changes of regional cerebral SvO2 among axonal injury (AI) patients, non-AI patients and healthy controls (HCs) using quantitative susceptibility mapping (QSM). 48 patients and 32 HCs were enrolled. The patients were divided into two groups depending on the imaging based evidence of AI. QSM was used to measure the susceptibility of major cerebral veins. Nonparametric testing was performed for susceptibility differences among the non-AI patient group, AI patient group and healthy control group. Correlation was performed between the susceptibility of major cerebral veins, elapsed time post trauma (ETPT) and post-concussive symptom scores. The ROC analysis was performed for the diagnostic efficiency of susceptibility to discriminate mTBI patients from HCs.The susceptibility of the straight sinus in non-AI and AI patients was significantly lower than that in HCs (P < 0.001, P = 0.004, respectively, Bonferroni corrected), which may indicate an increased regional cerebral SvO2 in patients. The susceptibility of the straight sinus in non-AI patients positively correlated with ETPT (r = 0.573, P = 0.003, FDR corrected) while that in AI patients negatively correlated with the Rivermead Post Concussion Symptoms Questionnaire scores (r = − 0.582, P = 0.018, FDR corrected). The sensitivity, specificity and AUC values of susceptibility for the discrimination between mTBI patients and HCs were 88%, 69% and 0.84. In conclusion, the susceptibility of the straight sinus can be used as a biomarker to monitor the progress of mild TBI and to differentiate mTBI patients from healthy controls.
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