Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre

Abstract

Between 1947 and 1992, 1403 patients with 1432 salivary gland tumours were treated at the Christie Hospital, Manchester. There were 1194 epithelial neoplasms: parotid, 1082 (91 per cent); submandibular, 47 (4 per cent); minor glands, 65 (5 per cent). The commonest histological diagnoses were pleomorphic adenoma (n = 776) and adenolymphoma (n = 159). A total of 244 carcinomas were seen (adenoid cystic carcinoma, n = 75). Treatment was primarily surgical, conservative where possible, and determined by tumour extent and not histology. Adjuvant radiation therapy was used in over half the definitively treated malignancies. The recurrence rate following the treatment of 551 new parotid pleomorphic adenomas was 1.6 per cent at median follow-up 12.5 (range 1-34) years, increasing to 15 per cent in the secondarily referred group (n = 170). For patients with definitively treated primary salivary carcinomas (n = 148), the disease-free survival rate at 5, 10 and 15 years was 58, 47 and 45 per cent respectively. Using multivariate analysis, clinical stage was the most important predictor of survival; the 10-year survival rate for stages I-IV was 96, 70, 47 and 19 per cent respectively.

Epithelial Salivary Gland Tumors in Two Distant Geographical Locations, Finland (Helsinki and Oulu) and Israel (Tel Aviv): A 10-Year Retrospective Comparative Study of 2,218 Cases

“…Earlier single-center studies that were also based on the 2005 WHO classification have reported these two tumors as being the most common malignant SGTs, but the order differed: one study found an equal frequency of these tumors [24], two studies found ACC to be more common [21,22], and the other two studies, including one from the UK, found mucoepidermoid carcinoma to be more common [9,23]. Before 2005, the frequency of mucoepidermoid carcinoma among British patients was much lower than the worldwide range [1], with a predominance of ACC [10,28]. Again, this demonstrates the changing trends in the incidence of SGT that can be related to a variety of factors, such as institutional referral bias and changing composition of the population.…”

Salivary Gland Carcinoma

“…The prognostic significance of the N-stage has also been highlighted in many previous reports. 3,4,[6][7][8][9][10]15 In contrast, the T-stage, its a-and …”

“…Postoperative radiotherapy is indicated when the resection margin is positive or close, 3,4 the tumour is high grade, 3,4 there is tumour infiltration of adjacent organs, or regional metastasis is extensive. 5,6 The prognosis depends on the stage [5][6][7][8] and grade 3,4,9 of the cancer, the completeness of surgical resection, and, when the resection is incomplete, whether or not postoperative radiotherapy is administered. [1][2][3]6,10 Unlike other high-grade salivary gland carcinomas, lymphoepithelioma-like carcinomas (LELCs) are very radiosensitive, [11][12][13] and radiotherapy has been used instead of surgery as the primary treatment of LELC.…”

“…5,6 The prognosis depends on the stage [5][6][7][8] and grade 3,4,9 of the cancer, the completeness of surgical resection, and, when the resection is incomplete, whether or not postoperative radiotherapy is administered. [1][2][3]6,10 Unlike other high-grade salivary gland carcinomas, lymphoepithelioma-like carcinomas (LELCs) are very radiosensitive, [11][12][13] and radiotherapy has been used instead of surgery as the primary treatment of LELC. 11 In addition, the prognosis of LELC in Hong Kong is good: the 5-year control rate exceeds 90% and the 4-year disease-free survival rate is higher than 80%.…”

A unique case of benign pleomorphic adenoma metastasizing to the thyroid gland and liver

“…40%-73% of recurrent tumours are multifocal as compared to 0.14%-0.6% in primary untreated pleomorphic adenoma [1] . Renehan et al have reported bone as the most common site for metastases (45%) followed by the head and neck (43%) and lung (36%) [4] . Metastatic deposits have also been discovered in regional lymph nodes, the oral cavity, pharynx, skin, liver, retroperitoneum, kidney, calvarium, and central nervous system [5] .…”