Long-term Follow-up of Initial 5-Fluorouracil Trabeculectomy in Primary Open-angle Glaucoma in Japanese Patients

Abstract

Trabeculectomy with 5-fluorouracil as an initial surgery in Japanese patients with primary open-angle glaucoma was effective for long-term control of glaucoma. However, the probability of late-onset bleb-related complications was not low in eyes with a functioning bleb, stressing the importance of constant care regarding bleb status.

Intermediate-term comparison of trabeculectomy with intraoperative mitomycin-C between Asian American and Caucasian glaucoma patients: a case-controlled comparison

“…12,24 Wong et al 12 reported the trabeculectomy survival with intraoperative 5-FU application to be 75.8% at 1 year and 65.8% at 3 years for the Asian patients in Singapore. The definition of success of that study was IOPo22 mmHg without additional medication or surgery.…”

Reducing intraocular pressure: is surgery better than drugs?

“…With surgery, levels of IOP in the low teens, or even lower, are technically achievable, 20,21,[34][35][36][37] and that is independent of the IOP values prior to surgery. What determines IOP levels postoperatively are mainly the degree of surgical precision intraoperatively, the resistance to outflow posed by the scleral flap in trabeculectomy, at least initially.…”

“…What determines IOP levels postoperatively are mainly the degree of surgical precision intraoperatively, the resistance to outflow posed by the scleral flap in trabeculectomy, at least initially. In the long run, the degree of wound scarring 30 postoperatively and whether this has been manipulated by antimetabolites, 21,35 plays a role of paramount importance.…”

“…12,15,16 Currently, topical ocular hypotensive medications, with its different classes, as well as filtering surgery (trabeculectomy and nonpenetrating surgery) are in the forefront of therapeutic modalities to reduce IOP. 15,[17][18][19][20][21][22][23] This review article looks at the potential advantages and disadvantages of topical medications vs filtering surgery and vice versa. It does not directly address the question of initial treatment of glaucoma, 20,21,[24][25][26][27][28][29] or what is the better treatment30 of glaucoma, as other review articles had, but rather looks in a more specific fashion on the pros and cons of each in relation to IOP reduction.…”

“…15,[17][18][19][20][21][22][23] This review article looks at the potential advantages and disadvantages of topical medications vs filtering surgery and vice versa. It does not directly address the question of initial treatment of glaucoma, 20,21,[24][25][26][27][28][29] or what is the better treatment30 of glaucoma, as other review articles had, but rather looks in a more specific fashion on the pros and cons of each in relation to IOP reduction. In other words, this review article deals with the situation once the decision has been made to reduce IOP.…”