Long-term follow-up of infants and children treated with extracorporeal membrane oxygenation (ECMO): A preliminary report

Towne, Barbara H.; Lott, Ira T.; Hicks, David; Healey, Timothy

doi:10.1016/s0022-3468(85)80230-x

Cited by 118 publications

(25 citation statements)

References 17 publications

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“…In patients treated with ECMO, including CDH-survivors, neurological deficits have been reported in 10-30% of patients [122][123][124][125][126][127]. Stolar et al [128] investigated the role of CDH in ECMO-treated infants with CDH by comparing ECMO survivors with CDH to other ECMO survivors.…”

Section: Long-term Follow-upmentioning

confidence: 99%

The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

et al. 2008

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Congenital diaphragmatic hernia (CDH) is a life-threatening anomaly with a mortality rate of approximately 40-50%, depending on case selection. It has been suggested that new therapeutic modalities such as nitric oxide (NO), high frequency oxygenation (HFO) and extracorporal membrane oxygenation (ECMO) might decrease mortality associated with pulmonary hypertension and the sequelae of artificial ventilation. When these new therapies indeed prove to be beneficial, a larger number of children with severe forms of CDH might survive, resulting in an increase of CDH-associated complications and/or consequences. In follow-up studies of infants born with CDH, many complications including pulmonary damage, cardiovascular disease, gastro-intestinal disease, failure to thrive, neurocognitive defects and musculoskeletal abnormalities have been described. Long-term pulmonary morbidity in CDH consists of obstructive and restrictive lung function impairments due to altered lung structure and prolonged ventilatory support. CDH has also been associated with persistent pulmonary vascular abnormalities, resulting in pulmonary hypertension in the neonatal period.

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Section: Long-term Follow-upmentioning

confidence: 99%

The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

et al. 2008

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“…The rest of the eight studies [18][19][20][21][22][23][24][25] reported following outcome with ECMO treatment. Four of them [18][19][20]25 showed adverse outcome. Three studies [21][22][23] showed that, although MAS infants had higher disabilities compared with the normal infants, they were better than infants with diaphragmatic hernia (CDH) and sepsis.…”

Section: Outcome Of Infants Following Ecmo Treatment In the 1980smentioning

confidence: 99%

Neurodevelopmental outcome of infants with meconium aspiration syndrome: report of a study and literature review

Beligere

Rao

2008

J Perinatol

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There is a paucity of information on long-term outcome of infants who have suffered from meconium aspiration syndrome (MAS) in the neonatal period. We analyzed long-term developmental outcome data of 35 infants who were admitted to the neonatal intensive care unit (NICU) at the University of Illinois Hospital at Chicago (UICMC) with a diagnosis of MAS, and we reviewed the literature pertinent to the subject. The objective of the study was to assess the neurodevelopment status of MAS infants and compare the possible effects of different variables that are known to affect the later developmental outcome. The variables included mode of delivery, APGAR score, cord pH, mode of treatment, and neurological findings during the course of NICU. The infants were enrolled in the developmental followup program (DFUP) after discharge from the nursery for assessment of long-term developmental status and neurodevelopmental outcome. In order to assess the impact of the treatment on long-term outcome and compare our findings with previously published reports, we also reviewed the previously published literature on neurodevelopment outcome of infants treated for MAS (with different modalities) during the last three decades. Total of 35 infants with a diagnosis of MAS admitted to the NICU at UICMC were followed in the DFUP clinic for 3 years during January 1999 to September 2001. The medical records of these infants were reviewed for the mode of delivery, APGAR score, birth weight (BW), gestational age, mode of treatment during the neonatal period, and neurodevelopment status. 19/35 (54%) infants were delivered vaginally, 16/35 (46%) by cesarean section (C-section). All were treated in the delivery room using the standard resuscitation protocol. Following initial resuscitation, all except three required intubation and ventilation for varying duration. One infant required inhaled nitric oxide therapy, and two required extracorporeal membrane oxygenation treatment. Subsequent to discharge, the infants were evaluated in the clinic at 2 months of age, and then every 4 months up to 3 years. The developmental assessment of mental development index (MDI), psychomotor development index (PDI), and behavior rating scale (BRS) were obtained using the Bayley II infant motor scale, and neurodevelopment evaluation was performed using the Amiel-Tison technique. Speech evaluation was performed in infants >18 months using the Rossetti Infant-Toddler language scale. Infants were considered normal when MDI and PDI scores were >85 to 110; mildly delayed when scores were >70 to 84; and severely delayed if the scores were <69. In addition, neurological evaluation also confirmed the disability. The report is based on the final analysis of 29 infants. Data of six infants were not included in the final analysis because of incomplete information. The mean BW of the infants was 3269±671 g; mean gestational age was 39.5±3.1 weeks. The median APGAR score at 1 0 was 4, and at 5 0 was 6. Out of 29, 11 (38%) infants were normal. Out of 29, 2 infants (7%) had cere...

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“…Between 10%-30% of patients treated with ECMO, including CDH-survivors, have neurological deficits (Towne et al, 1985;Glass et al, 1989;Schumacher et al, 1991). Among ECMO survivors, the diagnosis of CDH does not independently contribute to neurological risk although CDH infants are more unstable and have more complications while on ECMO .…”

Section: The Use Of Extracorporeal Membrane Oxygenation (Ecmo)mentioning

confidence: 99%

Predictors of Mortality and Morbidity in Infants with CDH

Aly¹,

Abdel‐Hady²

2012

Congenital Diaphragmatic Hernia - Prenatal to Childhood Management and Outcomes

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Long-term follow-up of infants and children treated with extracorporeal membrane oxygenation (ECMO): A preliminary report

Cited by 118 publications

References 17 publications

The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

Neurodevelopmental outcome of infants with meconium aspiration syndrome: report of a study and literature review

Predictors of Mortality and Morbidity in Infants with CDH

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