Long term follow-up of dogs diagnosed with leishmaniosis (clinical stage II) and treated with meglumine antimoniate and allopurinol

Torres, M.; Bardagí, Mar; Roura, Xavier; Zanna, Giordana; Ravera, Iván; Ferrer, L.

doi:10.1016/j.tvjl.2010.05.025

Cited by 71 publications

(92 citation statements)

References 25 publications

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“…However, this animal had been under treatment for one year, since receiving a diagnosis of leishmaniasis. Although the animal was serologically positive, the medication may have prevented the detection of the parasite in blood samples, bone marrow, and other tissues (TORRES et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Molecular and serological detection of Leishmania spp. in captive wild animals from Ilha Solteira, SP, Brazil

Jusi

Starke-Buzetti

Oliveira

et al. 2011

Rev. Bras. Parasitol. Vet.

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Leishmaniasis is a zoonotic disease that affects 12 million people worldwide. Several mammalian species can serve as a reservoir for this disease. Dogs are the main reservoir for visceral leishmaniasis in urban areas, which has become a serious public health concern in Brazil. The aim of this study was to evaluate the presence of Leishmania spp. in captive wild animals from Ilha Solteira, São Paulo, Brazil. Blood and various tissues samples were collected from animals of five different species: Speothos venaticus, Chrysocyon brachyurus, Cerdocyon thous, Pseudalopex vetulus, and Procyon cancrivorus. Antibodies against Leishmania spp. were detected in three wild canids by indirect fluorescent antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA). PCR analyses of blood and bone marrow from all animals were negative, but Leishmania DNA was found in the tissues and skin of seropositive animals. Positive PCR samples were also positive for Leishmania donovani complex. Analysis of sequenced PCR products showed similarities with different regions of Leishmania (Leishmania) infantum and Leishmania (Leishmania) chagasi kinetoplastids. Measures to control visceral leishmaniasis in wild animals kept in Brazilian zoos should be established, as no disease control programs are currently available.

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Section: Discussionmentioning

confidence: 99%

Molecular and serological detection of Leishmania spp. in captive wild animals from Ilha Solteira, SP, Brazil

Jusi

Starke-Buzetti

Oliveira

et al. 2011

Rev. Bras. Parasitol. Vet.

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“…Estudos sobre a capacidade de transmissão parasitária por cães após suspensão do uso do alopurinol em nossas condições precisam ser desenvolvidos para verificar se esses animais apresentariam recidivas. No entanto, utilizando outros protocolos terapêuticos, alguns autores já observaram recidivas da doença após a suspensão dessa droga (Ferrer et al 1995, Torres et al 2010. Há poucos trabalhos na literatura que reportaram o uso do xenodiagnóstico para avaliar a eficácia de diferentes tratamentos de cães com LV.…”

Section: Discussão E Conclusãounclassified

Avaliação da infectividade parasitária a Lutzomyia longipalpis por xenodiagnóstico em cães tratados para leishmaniose visceral naturalmente adquirida

et al. 2017

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RESUMO.-O efeito de um protocolo quimioterápico multidrogas contra a leishmaniose visceral (LV) canina, sobre a capacidade de transmissão de Leishmania infantum ao vetor, foi analisado por meio de xenodiagnóstico. Trinta e cinco cães naturalmente infectados foram avaliados antes e durante o tratamento com a combinação de metronidazol, cetoconazol e alopurinol a cada três meses por até um ano. Em cada avaliação, os cães foram individualmente submetidos ao xenodiagnóstico e quantificação da carga parasitária por PCR quantitativa. O tratamento foi eficaz em bloquear a transmissibilidade parasitária do cão para o flebotomíneo (p= 0,011) nos cães avaliados. Houve significante correlação entre recuperação clínica e infectividade: cães com melhora clínica mais evidente apresentaram menores chances de transferir L. infantum ao Lutzomyia longipalpis via xeno-

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“…Opinions on optimal and ethical treatment vary with compulsory culling still current in some countries, whereas increasingly sophisticated treatments are employed elsewhere (Gramiccia, 2011 andDantas-Torres et al, 2012). While some question the ability to truly cure canine leishmaniosis (Ribeiro et al, 2008, Manna et al, 2009and Torres et al, 2011 clinical cures can be achieved with some dogs no longer infectious through their biological vectors ( da Silva et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The diagnosis and management of a case of leishmaniosis in a dog imported to Australia

Best¹,

Ash

Bergfeld

et al. 2014

Veterinary Parasitology

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Long term follow-up of dogs diagnosed with leishmaniosis (clinical stage II) and treated with meglumine antimoniate and allopurinol

Cited by 71 publications

References 25 publications

Molecular and serological detection of Leishmania spp. in captive wild animals from Ilha Solteira, SP, Brazil

Molecular and serological detection of Leishmania spp. in captive wild animals from Ilha Solteira, SP, Brazil

Avaliação da infectividade parasitária a Lutzomyia longipalpis por xenodiagnóstico em cães tratados para leishmaniose visceral naturalmente adquirida

The diagnosis and management of a case of leishmaniosis in a dog imported to Australia

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