Long-Term Follow-Up of Cytostatic
Intravesical Instillation in Patients
with Superficial Bladder Carcinoma

Schwaibold, Hartwig; Pichlmeier, Uwe; Klingenberger, Hans-Jörg; Huland, Hartwig

doi:10.1159/000474441

Cited by 17 publications

(9 citation statements)

References 17 publications

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“…There was a small nonsignificant decrease in the percentage of patients with recurrence in the group receiving 8 weekly instillations, 17.7% versus 24.4% [26,27].…”

Section: Frequent Early Instillations Versus Less Frequent Early Instmentioning

confidence: 80%

“…Other studies did not find a difference in efficacy between different drug concentrations [31][32][33][34]36]. Weekly instillations during 5 mo appear to be as effective as long-term instillations during 3 yr, which were given less frequently during the initial 5-mo period [26,27]. Thus, some evidence indicates that an initial intense schedule of instillations is of benefit and may be as effective as less intense long-term treatment.…”

Section: Discussionmentioning

confidence: 93%

“…Frequent short-term instillations versus less frequent early instillations followed by long-term instillations (different total dose): Weekly instillations of MMC 20 mg/20 ml for 20 wk were compared to weekly instillations for 8 wk followed by monthly instillations to 3 yr (42 instillations) and to instillations every 2 wk during 1 yr followed by monthly instillations during year 2 and 3 monthly instillations during year 3 (42 instillations). There was no difference in efficacy between the frequent short-term instillations and either of the less intense long-term instillations [26,27].…”

Section: More Intense or Frequent Short-term Instillations Compared Tmentioning

confidence: 85%

“…Three years of chemotherapy-Weekly instillations of MMC for 20 wk were compared to either weekly instillations for 8 wk followed by monthly instillations to 3 yr (42 instillations) or to instillations every 2 wk during 1 yr followed by monthly instillations during year 2 and 3 monthly instillations during year 3 (42 instillations) [26,27]. There was no difference in the percentage who had a recurrence on 20 wk or 3 yr of treatment; however, the comparisons are confounded by different treatment intensities during the initial 20 wk.…”

Section: Two Years Of Chemotherapy-two Trials Compared Weekly Instillmentioning

confidence: 99%

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The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

2008

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Objectives-Intravesical chemotherapy has been studied in randomized clinical trials for >30 yr; however, the optimal schedule and duration of treatment are unknown. The objective is to determine the effect of schedule and duration of intravesical chemotherapy on recurrence in patients with stage Ta T1 bladder cancer.Methods-A systematic review was conducted of the published results of randomized clinical trials that compared intravesical instillations with respect to their number, frequency, timing, duration, dose, or dose intensity.

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“…There was a small nonsignificant decrease in the percentage of patients with recurrence in the group receiving 8 weekly instillations, 17.7% versus 24.4% [26,27].…”

Section: Frequent Early Instillations Versus Less Frequent Early Instmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 93%

Section: More Intense or Frequent Short-term Instillations Compared Tmentioning

confidence: 85%

Section: Two Years Of Chemotherapy-two Trials Compared Weekly Instillmentioning

confidence: 99%

See 2 more Smart Citations

The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

2008

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“…By checking reference lists of the 15 articles, 2 new essays revealed the relevance. With a comparison of data and trial designs of the 17 articles, 3 duplicated papers [19][20][21] describing one trial and 2 repeated articles [17,22] describing another trial were discovered. The rest 12 papers reported other 12 different trials.…”

Section: Results Of the Searchmentioning

confidence: 99%

Long-term versus short-term introvesical chemotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis of the published results of randomized clinical trials

Teng

Xing

Liu

et al. 2014

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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In order to assess the effect of long-term versus short-term intravesical chemotherapy in preventing the recurrence of patients with non-muscle-invasive bladder cancer, we searched several databases with words as mesh terms and free text words to find all eligible randomized clinical trials (RCTs) for the comparison of the two strategies of instillation durations. "Observed-Expected events research (O-E)" and "Variance (V)" for calculating hazard ratio (HR) were used in Revman 5.2 software recommended by Cochrane Collabration for data analysis. Sensitivity and subgroup analysis were selected to minish heterogeneity. GRADEpro 3.6 profile recommended by Cochrane Collabration was employed for quality assessment of analyses. Finally, 13 eligible RCTs with 4216 patients were included in this review and 16 comparisons from 13 trials were involved for analysis. The pooled analysis revealed no significant difference between long-term and short-term duration [HR=0.99, 95% CI (0.89, 1.11), P=0.89]. Within the subgroup analysis, patients benefited from long-term instillations with a start regimen of one immediate instillation [HR=0.83, 95% CI (0.69, 1.00), P=0.05]. But patients were not suitable to receive long-term instillations with epirubicin (EPI) [HR=1.01, 95% CI (0.91, 1.13), P=0.78]. The progression rate was not reduced after long-term instillations [HR=0.96, 95% CI (0.66, 1.39), P=0.82]. From our results, patients should not receive introvesical chemotherapy more than half a year. In contrast, patients with one immediate instillation are preferred to have a long-term duration at least one year. Long-term instillations can not reduce the progression rate.

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Oberflächliches Urothelkarzinom der Harnblase

Kälble

1998

Der Urologe B

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Angesichts der Rezidivhäufigkeit von oberflächlichen Blasenkarzinomen nach transurethraler Elektroresektion werden seit Jahren verschiedene Chemotherapeutika sowie Bacillus-Calmette-GuØrin (BCG) intravesikal zur Rezidivprophylaxe erfolgreich eingesetzt. Bislang hat kein Chemotherapeutikum einen günstigen Einfluû auf das Progressionsverhalten gezeigt, bezüglich BCG sind die Studienergebnisse widersprüchlich. Beim Carcinoma in situ ist die Therapie der Wahl die BCG-Instillation, beim T 1 G 3 -Karzinom konkurrieren ein BCG-Therapieversuch mit der sofortigen radikalen Zystektomie. In der folgenden Übersicht wird der aktuelle Stand der Therapie des oberflächlichen Harnblasenkarzinoms kritisch dargestellt. Der Urologe [B] 4´98 333 Urologe [B]

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Long-Term Follow-Up of Cytostatic Intravesical Instillation in Patients with Superficial Bladder Carcinoma

Cited by 17 publications

References 17 publications

The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

The Schedule and Duration of Intravesical Chemotherapy in Patients with Non–Muscle-Invasive Bladder Cancer: A Systematic Review of the Published Results of Randomized Clinical Trials

Long-term versus short-term introvesical chemotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis of the published results of randomized clinical trials

Oberflächliches Urothelkarzinom der Harnblase

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