Long-term follow-up of cancer in neonates and infants: a national survey of 142 patients

Abstract

To determine the mortality and survival rates, side effects of surgery and adjuvant chemo- and radiotherapy, somatic development, and fertility, the data of 142 patients under the age of 1 year operated upon for solid malignant tumors from 1975 through 1983 were analyzed. The follow-up period ranged from 16 to 25 years (mean 20); 79 patients survived. The male/female ratio of the survivors was 51/28. Investigations were based on the Hungarian Tumor Registry, personal interviews with the patients and their parents, and detailed questionnaires. Fifty-one patients died, 44 of them before the age of 3 years; 13 were lost to follow-up. Of the 79 survivors, 48 had abdominal and 31 extra-abdominal tumors (35 neuroblastomas, 21 renal tumors, 15 soft-tissue sarcomas, 5 gonadal tumors, 2 sacrococcygeal carcinomas, 1 hepatic tumor). Side effects of surgical intervention included partial urinary incontinence (2), partial fecal incontinence (1), intestinal obstruction (2), nerve injury (1), thorax deformity (4), and scar formation resulting in psychological problems (12). Chemotherapy alone (41 patients) resulted in side effects in 19 patients, radio- and chemotherapy in combination (23) caused side effects in 20. Fifteen patients did not receive adjuvant therapy. The most serious late side effects were 24 spinal deformities, one-half of them severe, breast underdevelopment, muscular deformity, and renal damage. In 19 patients more then one side effect was detected. Height and weight gain decreased ( P < 0.01 and <0.05, respectively) in the first 8-10 years of follow-up and accelerated significantly ( P < 0.05 and <0.05, respectively) in the second half of follow-up. The short follow-up time (16-25 years) permitted only limited analysis of infertility. Whenever possible, surgical excision should be the treatment of choice. No routine aggressive chemotherapy is indicated. Radiation therapy, which frequently results in long-term musculoskeletal morbidity, should be avoided. Catch-up somatic development occurred in the second part of the follow-up period.

A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

“…An NWTS analysis (n = 680) also reported a higher prevalence of scoliosis or kyphosis among survivors who had received radiation (51.4%) compared to those who had not (4.1%) (24). The evidence for the association between radiotherapy and spinal malalignment is strengthened by other studies (4, 21–23, 27, 28, 30, 34, 36, 42–55). …”

“…All but two studies (24, 29) describing associations between radiotherapy and muscular late effects had small sample sizes (21–23, 25–28, 30, 32–36). Among 185 survivors of Wilms tumor treated at a median age of 3.7 and followed for a median of 18.9 years, Van Dijk et al .…”

A 15-year-old Girl with an Asymmetric Hemitruncal Fat Distribution: Hemihyperthrophy or Hemiatrophy?

“…However, it does not correspond to the breast asymmetry. In a study by Pintér et al 12 1 of 10 patients had breast underdevelopment after chemotherapy increasing to 2 of 9 patients after a combination of chemotherapy and radiation therapy. In addition to radiotherapy, anthracycline chemotherapeutics are found to be independent risk factors for tissue hypoplasia.…”

Protonentherapie mit „Spot-Scanning“ bei Rhabdomyosarkomen im frühen Kindesalter

“…Betroffen sind u.a. typischerweise Wachstum, Knochensymmetrie, Zahnentwicklung, Sinnesorgane, Hormonstatus und Fertilität [22,23]. Auch sind natürlicherweise gerade die Lokalisationen, die einer radikalen Operation schwer zugänglich sind, z.B.…”