Long-term follow-up of acute myocarditis. Correlation of ventricular function and outcome

Quigley, P. J.; Richardson, PJ; Meany, Brendan; Olsen, E. G. J.; Monaghan, Mark; Jackson, Gregory R.; Jewitt, D E

doi:10.1093/eurheartj/8.suppl_j.39

Cited by 80 publications

(30 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Early spontaneous LV function recovery has been previously described in 39% of patients with EMB-proven AM 16 , whereas significant early improvement of LV function has been demonstrated in 60% of patients with AM during immunosuppressive treatment. 17 In both series, LV function recovery was invariably associated with excellent mid-term prognosis.…”

Section: Role Of Short-term Reevaluationmentioning

confidence: 93%

Long-Term Evolution and Prognostic Stratification of Biopsy-Proven Active Myocarditis

et al. 2013

View full text Add to dashboard Cite

Background-Active myocarditis is characterized by large heterogeneity of clinical presentation and evolution. This study describes the characteristics and the long-term evolution of a large sample of patients with biopsy-proven active myocarditis, looking for accessible and valid early predictors of long-term prognosis. Methods and Results-From 1981 to 2009, 82 patients with biopsy-proven active myocarditis were consecutively enrolled and followed-up for 147±107 months. All patients underwent clinical and echocardiographic evaluation at baseline and at 6 months. At this time, improvement/normality of left ventricular ejection fraction (LVEF), defined as a LVEF increase > 20 percentage points or presence of LVEF≥50%, was assessed. At baseline, left ventricular dysfunction (LVEF<50%) and left atrium enlargement were independently associated with long-term heart transplantation-free survival, regardless of the clinical pattern of disease onset. At 6 months, improvement/normality of LVEF was observed in 53% of patients. Persistence of New York Heart Association III to IV classes, left atrium enlargement, and improvement/normality of LVEF at 6 months emerged as independent predictors of long-term outcome. Notably, the short-term reevaluation showed a significant incremental prognostic value in comparison with the baseline evaluation (baseline model versus 6 months model: area under the curve 0.79 versus 0.90, P=0.03). Conclusions-Baseline left ventricular function is a marker for prognosis regardless of the clinical pattern of disease onset,and its reassessment at 6 months appears useful for assessing longer-term outcome.

show abstract

Section: Role Of Short-term Reevaluationmentioning

confidence: 93%

Long-Term Evolution and Prognostic Stratification of Biopsy-Proven Active Myocarditis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…However, these are patients with end-stage-dilated cardiomyopathies, and it is known that dilated cardiomyopathy may occur after myocarditis. 6,7,23 It is, therefore, our intention to investigate whether there is abnormal MHC expression in myocarditis.…”

Section: Discussionmentioning

confidence: 99%

End-stage dilated cardiomyopathy. Persistence of enterovirus RNA in myocardium at cardiac transplantation and lack of immune response.

et al. 1989

View full text Add to dashboard Cite

show abstract

“…Studies in animal models show progressive ventricular dysfunction and dilatation in the presence of chronic viral myocarditis. 29 Long term follow up studies on patients with acute myocarditis have shown a variable incidence of dilated cardiomyopathy, ranging from 0-52%, over a mean period of three years (range three months to 13 years) ( biopsy findings, 12 …”

Section: Evolution To Dilated Cardiomyopathymentioning

confidence: 99%

“…12 These data, however, reflect diVerences in diagnosis and patient selection. In particular, Quigley and colleagues described evolution to dilated cardiomyopathy in a group of 23 patients with biopsy proven acute myocarditis during a five year follow up.…”

Section: Evolution To Dilated Cardiomyopathymentioning

confidence: 99%

Double orifice mitral valve associated with non-compaction of left ventricle

Kamei¹

2001

Heart

View full text Add to dashboard Cite

Long-term follow-up of acute myocarditis. Correlation of ventricular function and outcome

Cited by 80 publications

References 0 publications

Long-Term Evolution and Prognostic Stratification of Biopsy-Proven Active Myocarditis

Long-Term Evolution and Prognostic Stratification of Biopsy-Proven Active Myocarditis

End-stage dilated cardiomyopathy. Persistence of enterovirus RNA in myocardium at cardiac transplantation and lack of immune response.

Double orifice mitral valve associated with non-compaction of left ventricle

Contact Info

Product

Resources

About