Abstract:1978
To study the evolution and prognosis in familial cases of myeloproliferative neoplasms (MPN), we collected clinical data and blood samples from 94 families defined by the presence of at least two affected subjects with one MPN. A total of 228 subjects including 99 polycythemia vera (PV), 104 essential thrombocythemia (ET), 14 primary myelofibrosis (PMF) and 11 chronic myeloid leukaemia (CML) were recruited. Occurrence was vertical in 63 families involving 2 generations in 48, 3 generations … Show more
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