Long-term Follow-up in Patients with Neurocardiogenic Syncope with or without Therapy

Ahn, Seok-Jin; Kim, June Soo; Hà, Khánh Linh; Hong, Sun Hee; Cho, Wook Hyun; Lee, Sang‐Chol; Park, Seung Woo; Gwon, Hyeon‐Cheol; Kim, Duk-kyung; Lee, Sang Hoon; Hong, Kyung Pyo; Park, Jeong Euy; Seo, Jung Don; Lee, William R.

doi:10.4070/kcj.1998.28.9.1502

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Cox et al 11) reported that the recurrence rate was 42% in patients who stopped drugs, which was effective on repeat HUT. Ahn et al 12) reported that the recurrence rate was 7.1% in patients who were treated on drugs guided by repeat HUT, 16.7% in patients with empirical drug treatment, and 22.4% in patients who stopped drug during follow-up.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Recurrence Rate Based on the Frequency of Preceding Symptoms in Patients With Neurocardiogenic Syncope or Presyncope

Lee

Kim

et al. 2011

Korean Circ J

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Background and ObjectivesIn patients with neurocardiogenic syncope or presyncope, symptoms developed unpredictably and intermittently. The purpose of this study was to determine whether there was any significant difference in the recurrence rate of symptoms during the follow-up period between patients with many episodes of symptoms and those with fewer episodes of symptoms before diagnosis, as well as to assess the clinical significance of previous episodes of symptoms during treatment.Subjects and MethodsA total of 100 patients with neurocardiogenic syncope or presyncope were divided in two groups (high episode group, n=54; low episode group, n=46) according to the frequency of symptoms before the head-up tilt test. We retrospectively analyzed the recurrence of symptoms using telephone interviews and medical record reviews.ResultsThe clinical characteristics were not significantly different between the two groups. However, the recurrence rate was significantly lower in the high episode group than in the low episode group (5.6% vs. 19.6%, p=0.001). In the high episode group, patients treated with medication showed higher recurrence of symptoms than those without medication. In the lower episode group, a similar result was observed.ConclusionThe frequency of previous symptoms at the diagnosis of neurocardiogenic syncope or presyncope did not predict the occurrence of symptoms during the follow-up period. Therefore, to continue drug treatment based on the frequency of symptoms in patients with neurocardiogenic syncope or presyncope may not be the best option.

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Section: Discussionmentioning

confidence: 99%

Comparison of Recurrence Rate Based on the Frequency of Preceding Symptoms in Patients With Neurocardiogenic Syncope or Presyncope

Lee

Kim

et al. 2011

Korean Circ J

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Heart Rate Variability in Patients with Neurocardiogenic Syncope or Presyncope

Kim

Ahn

et al. 2000

Korean Circ J

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Background and Objectives Neurocardiogenic syncope is believed to be caused by a transient imbalance of autonomic nervous system. Actually, there were significant differences in heart rate variability HRV indices during head-up tilt test between patients with neurocardiogenic syncope and normal controls. But there was no definite evidence for it during daily activity. So, we tried to evaluate HRV during daily activity with 24-hour ambu-latory electrocardiography monitoring. Materials and Methods 27 patients with neurocardiogenic syncope or presyncope mean age 45 3 and 25 normal volunteers mean age 47 2 comparable for age and sex underwent 24-hour ambulatory electrocardiography. Head-up tilt test was used to diagnose neurocardiogenic syncope or presyncope in patients group. HRV was analysed over the whole 24 hours, using time and frequency domain parameters. Student's t-test was applied. Results There were no significant differences in HRV measures between two groups, over 24-hour period and day-time and night-time period. But the hourly HRV measures showed a transient decrease of LF, LFnorm and LF HF ratio in patients group compared to normal control group. Conclusions These results indicate that patients with neurocardiogenic syncope or presyncope suffer from temporarily decreased sympathetic tone with normal parasympathetic tone. So, transient additive change of autono-mic nervous tone may cause syncope or presyncope in these patients. Korean Circulation J 2000 ; 30 6 : 716-723

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