Long-term follow-up for ectopic ACTH-secreting pituitary adenoma in a single tertiary medical center and a literature review

Zhu, Jianyu; Lü, Lin; Yao, Yong; Chen, Shi; Li, Wei; You, Hui; Feng, Feng; Feng, Ming; Zhang, Yi; Wang, Zhicheng; Sun, Xu; Li, Xiaoxu; Zhu, Huijuan; Wang, Renzhi; Lü, Zhiyong

doi:10.1007/s11102-019-01017-y

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…While the exact pathogenic mechanism of EPA has not yet been determined, it is broadly accepted that the tumor originates from the embryonic residues of pituitary cells along the path of migration of Rathke’s pouch ( 5 , 6 ). Although the origin of EPA is the same as that of the adenohypophysis, EPA refers to pituitary adenomas located completely outside of the sellar turcica without a direct connection to the intrasellar normal pituitary gland or pituitary stalk ( 7 , 8 ). In a literature review of 85 EPA cases, 72 (85%) EPAs secreted 1 or more hormones, and the most commonly secreted hormone was ACTH (36%), followed by PRL (28%), GH (22%), and TSH (16%) ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region

Zhao

Hou

et al. 2021

Front. Endocrinol.

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Ectopic thyrotropin-secreting pituitary adenoma (ectopic TSH-oma) is a rare disorder that is easily misdiagnosed in clinical work. We report one patient who presented with hyperthyroidism and a suprasellar mass. In this case, preoperative diagnosis of suprasellar ectopic thyrotropin-secreting pituitary adenoma was challenging. A literature review revealed that a total of 11 patients with ectopic TSH-oma were previously reported, and only our one case was diagnosed in the microadenoma stage. Most of the patients with TSH-oma or ectopic TSH-oma were middle-aged. We described ectopic TSH-oma in a child at length. We recommend that ectopic TSH-oma should be considered in the differential diagnosis of thyrotoxicosis syndrome to achieve an accurate, early diagnosis. The somatostatin suppression test and imaging examinations, such as magnetic resonance imaging and positron emission tomography/magnetic resonance imaging, could contribute to the diagnosis. Once the diagnosis was highly suspected, tumor resection could achieve a satisfying long-term outcome in ectopic TSH-oma.

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Section: Discussionmentioning

confidence: 99%

Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region

Zhao

Hou

et al. 2021

Front. Endocrinol.

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“…Of note, ACTH-secreting adenomas represent the most common phenotype among the hormonally active EPTs [54, 55], followed by PRL-secreting tumors [50]. GH- and TSH-secreting tumors have been also described, the latter being relatively more common in EPTs compared to typical intrasellar PTs (15 vs. 1–2%).…”

Section: Parasellar Lesions: Who Are the Players?mentioning

confidence: 99%

Diagnosis and Treatment of Parasellar Lesions

et al. 2020

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The parasellar region, located around the sella turcica, is an anatomically complex area representing a crossroads for important adjacent structures. Several lesions, including tumoral, inflammatory vascular, and infectious diseases may affect this area. Although invasive pituitary tumors are the most common neoplasms encountered within the parasellar region, other tumoral (and cystic) lesions can also be detected. Craniopharyngiomas, meningiomas, as well as Rathke's cleft cysts, chordomas, and ectopic pituitary tumors can pri

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“…3 Finding such lesions in non-pituitary intracranial regions is extremely rare, and ectopic ACTH in the clivus region is even rarer. To date, less than 60 cases of ectopic ACTHsecreting pituitary adenomas have been reported, 4 and determining their localization is a formidable challenge in CS diagnosis. It is difficult to make an accurate and prompt diagnosis of ectopic ACTH-secreting pituitary adenoma caused by hypercortisolism based on its clinical manifestation, routine laboratory tests, and radiologic examinations.…”

Section: Introductionmentioning

confidence: 99%

“…It is difficult to make an accurate and prompt diagnosis of ectopic ACTH-secreting pituitary adenoma caused by hypercortisolism based on its clinical manifestation, routine laboratory tests, and radiologic examinations. 1,4 Ectopic pituitary adenomas (EPAs) are mainly concentrated in the sphenoid sinus, suprasellar region, and cavernous sinus, and rare regions include the clivus, ethmoid sinus, and nasal cavity. 5 A literature review showed that only three cases of primary EPA in the clivus region have been reported worldwide.…”

Section: Introductionmentioning

confidence: 99%

Ectopic Adrenocorticotropic Hormone-Secreting Pituitary Adenoma in the Clivus Region: A Case Report

Zhang¹,

Wu²,

Wang³

et al. 2022

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Ectopic pituitary adenoma (EPA) is a pituitary adenoma unrelated to the intrasellar component and is an extremely rare disease. EPA resembles typical pituitary adenomas in morphology, immunohistochemistry, and hormonal activity, and it may present with specific or non-specific endocrine manifestations. Here, we report a rare case of ectopic adrenocorticotropic hormone (ACTH)secreting pituitary adenoma in the clival region. Only three patients with ACTH-secreting pituitary adenomas occurring in the clivus have been previously reported, and the present case was diagnosed as a clivus-ectopic ACTH-secreting pituitary macroadenoma. Thus, in addition to the more common organs, such as the lung, thymus, and pancreas, in the diagnosis of ectopic ACTH syndrome, special attention should be paid to the extremely rare ectopic ACTH-secreting pituitary adenoma of the clivus region.

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Long-term follow-up for ectopic ACTH-secreting pituitary adenoma in a single tertiary medical center and a literature review

Cited by 6 publications

References 62 publications

Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region

Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region

Diagnosis and Treatment of Parasellar Lesions

Ectopic Adrenocorticotropic Hormone-Secreting Pituitary Adenoma in the Clivus Region: A Case Report

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