Long-term follow-up evaluation of renal function in patients treated with peritoneal dialysis after cardiac surgery for correction of congenital anomalies

Mel, Eran; Davidovits, Miriam; Dagan, Ovadia

doi:10.1016/j.jtcvs.2013.03.032

Cited by 19 publications

(19 citation statements)

References 16 publications

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“…Until recently, AKI has been viewed as a transient, self‐limiting syndrome, but this hypothesis is being disproved by multiple observational studies, pointing to long‐term kidney damage even after a single AKI episode . More than 50% of patients with childhood AML will require an allogeneic HSCT to consolidate high‐risk disease or to salvage relapse disease.…”

Section: Discussionmentioning

confidence: 99%

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High incidence of acute kidney injury during chemotherapy for childhood acute myeloid leukemia

Plessis

Rassekh

Mammen

2017

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

“…As shown in several studies involving critically ill children, AKI is independently associated with an increase in mortality, ventilation requirements, and hospital length of stay . Survivors of AKI are also at risk of developing chronic kidney disease (CKD) later in life …”

Section: Introductionmentioning

confidence: 99%

High incidence of acute kidney injury during chemotherapy for childhood acute myeloid leukemia

Plessis

Rassekh

Mammen

2017

Pediatric Blood & Cancer

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“…77 A study reported by Mel et al of 25 children who required peritoneal dialysis for cardiac surgery-associated AKI showed that only one patient had a reduction in eGFR at a mean follow up of 5 years, and none developed proteinuria. 78 A recent study by Cooper et al followed 51 children who underwent cardiopulmonary bypass (33 with AKI defined as a ≥50% increase in serum creatinine from baseline and 18 without AKI) for a mean duration of 7 years. 79 Children in both groups displayed normal eGFR, normal blood pressures, and normal levels of proteinuria and microalbuminuria.…”

Section: Aki To Ckd – Clinical Evidencementioning

confidence: 99%

Progression of chronic kidney disease after acute kidney injury

Devarajan

Jefferies

2016

Progress in Pediatric Cardiology

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The incidence of chronic kidney disease (CKD) in children and adults is increasing. Cardiologists have become indispensable members of the care provider team for children with CKD. This is partly due to the high incidence of CKD in children and adults with congenital heart disease, with current estimates of 30–50%. In addition, the high incidence of acute kidney injury (AKI) due to cardiac dysfunction or following pediatric cardiac surgery that may progress to CKD is also well documented. It is now apparent that AKI and CKD are uniquely intertwined as interconnected syndromes. Furthermore, the well-known long-term cardiovascular morbidity and mortality associated with CKD require the joint attention of both nephrologists and cardiologists. Children with both congenital heart disease and CKD are increasingly surviving to adulthood, with synergistically negative medical, financial, and quality of life impact. An improved understanding of the epidemiology, mechanisms, early diagnosis, and preventive measures is of importance to cardiologists, nephrologists, scientists, economists, and policy makers alike. Herein, we report the current definitions, epidemiology, and complications of CKD in children, with an emphasis on children with congenital heart disease. We then focus on the clinical and experimental evidence for the progression of CKD after episodes of AKI commonly encountered in children with heart disease, and explore the role of novel biomarkers for the prediction of CKD progression.

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“…Mel et al showed that long-term renal prognosis in survivors was good in 76 children in whom postoperative AKI developed and who were managed with PD in a single-center, cohort study at long-term follow-up (3.5–10.5 years). Of the 76 children included in that study, 35 died during the immediate postoperative period, 15 died during the interim of nonrenal causes, and 26 were alive at the time of follow-up evaluation [62]. There is a possibility that pediatric patients with AKI after cardiac surgery have a different prognosis from that for adult patients with AKI after cardiac surgery.…”

Section: Introductionmentioning

confidence: 99%

AKI after pediatric cardiac surgery for congenital heart diseases–recent developments in diagnostic criteria and early diagnosis by biomarkers-

Toda

Sugimoto

2017

j intensive care

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BackgroundAcute kidney injury (AKI) after cardiac surgery in children with congenital heart disease is a common complication. AKI is also associated with high morbidity and mortality. The Kidney Diseases Improving Global Outcomes (KDIGO) criteria for AKI classification are now widely used for the definition of AKI. It is noteworthy that a statement about children was added to the criteria. Many studies aimed at finding useful biomarkers are now being performed by using these criteria. Clinicians should be aware of the recent progress in understanding AKI in children.Main contentsUnlike adult patients, young age is one of the major risk factors for AKI in pediatric cardiac surgery. The mechanism of the development of AKI in children might be different from that in adults because the surgical procedure and CPB technique in pediatric patients are greatly different from those in adult patients.There are many biomarkers for early detection of AKI, and some of them are widely used in hospitals. One of the major benefits of such biomarkers is the rapidness of expression for detecting increases in their expression levels. Neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, cystatin C, and albumin have been investigated in some studies, and the usefulness of these biomarkers for detection of AKI and diagnosis of disease severity has been shown.Although there are many interventions for preventing and treating AKI after cardiac surgery in children, there is still no specific effective treatment. Peritoneal dialysis is effective for only maintaining a negative fluid balance early after cardiac surgery. The long-term prognosis of AKI is an issue of interest. Although mortality and morbidity of AKI in the acute phase of disease remain high, the long-term condition in pediatric patients is relatively acceptable unlike in adults.ConclusionsKDIGO criteria are advocated as a diagnostic tool for common perception. Early recognition and intervention for AKI can be achieved by using several biomarkers. Further studies are needed to establish effective treatment for AKI.

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Long-term follow-up evaluation of renal function in patients treated with peritoneal dialysis after cardiac surgery for correction of congenital anomalies

Abstract: Despite the development of AKI requiring dialysis after surgical correction of congenital cardiac anomalies, the long-term renal prognosis in survivors is good.

Cited by 19 publications

References 16 publications

High incidence of acute kidney injury during chemotherapy for childhood acute myeloid leukemia

High incidence of acute kidney injury during chemotherapy for childhood acute myeloid leukemia

Progression of chronic kidney disease after acute kidney injury

AKI after pediatric cardiac surgery for congenital heart diseases–recent developments in diagnostic criteria and early diagnosis by biomarkers-

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