Long‐term follow‐up after cure of <i>Helicobacter pylori</i> infection with 4 days of quadruple therapy

Lai, J. Y. L.; Boer, W. A. De; Driessen, W. M. M.; Geuskens, L.M.

doi:10.1046/j.1365-2036.1996.43185000.x

Cited by 21 publications

(16 citation statements)

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“…Reinfection during the follow up period is extremely unlikely 32. Although only a single genotype was detected before treatment, other genotypes may already have been present before treatment at a low concentration or may have remained undetected owing to sampling variation during endoscopy.…”

Section: Discussionmentioning

confidence: 99%

Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment

Doorn

Schneeberger²,

Nouhan³

et al. 2000

Gut

132

124

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Background-Virulence factors of Helicobacter pylori are associated with peptic ulcer disease and may be also associated with the eYcacy of treatment. Aims-To determine the relation between the vacA and the cagA status of H pylori, clinical disease, and treatment outcome. Patients-121 patients with H pylori infection and peptic ulcer disease or functional dyspepsia were treated by quadruple antibiotic therapy in two groups for one and two days, respectively. Methods-DNA was isolated from gastric antral biopsy specimens, taken before and after treatment, and the vacA and cagA status was determined by polymerase chain reaction and reverse hybridisation. Results-Peptic ulcer disease was significantly associated with the vacA s1 type, and cagA positivity, but not with the vacA m type. Treatment eYcacy was significantly higher in patients with peptic ulcer disease, or infected with cagA+/vacA s1 strains. Conclusions-The strong association between the cagA and vacA status and peptic ulcer disease was confirmed. Cure rates seem to be higher for patients with cagA+/ vacA s1 H pylori strains, which is consistent with the higher cure rate observed among ulcer patients compared with functional dyspepsia patients. Therefore, treatment studies may require stratification for presence of ulcers as well as H pylori genotypes. (Gut 2000;46:321-326)

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Section: Discussionmentioning

confidence: 99%

Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment

Doorn

Schneeberger²,

Nouhan³

et al. 2000

Gut

132

124

View full text Add to dashboard Cite

show abstract

“…One further step would be taken towards the ultimate goals of identifying a one‐dose ‘magic bullet’ which eliminates H. pylori and prevents the emergence of multiple drug resistant strains of the bacterium. There are preliminary studies of H. pylori eradication regimens of 1–6 day duration but these are pilot experiments, performed in small numbers of patients with sub‐optimal design 5 –8 . The aim of this study was to test two 3‐day H. pylori eradication regimens against a standard one‐week regimen, in a prospective, randomized format with a minimum of 50 patients in each study arm 9…”

Section: Introductionmentioning

confidence: 99%

Comparison of two 3‐day Helicobacter pylori eradication regimens with a standard 1‐week regimen

Grimley

Penny

O'Sullivan

et al. 1999

Aliment Pharmacol Ther

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“…The results corroborate those of previous reports that quadruple therapies present a promising alternative to current standard first‐line Helicobacter pylori therapies 15 , . 23 –30 Those studies have shown that 4 days of quadruple therapy achieve cure rates over 90% and that a 14‐day quadruple therapy will cure even patients with in vitro metronidazole resistance 15 …”

Section: Discussionmentioning

confidence: 99%

Modified seven‐day, quadruple therapy as a first line Helicobacter pylori treatment

Calvet

García

Gené

et al. 2001

Aliment Pharmacol Ther

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Background: Cure rates of 7‐day triple therapy seem to be decreasing. Quadruple therapies may be an alternative, although their complex administration makes patient acceptance difficult. Objective: To test the usefulness of a thrice a day, quadruple therapy to cure Helicobacter pylori infection. Patients and methods: A total of 122 consecutive patients with peptic ulcer and Helicobacter pylori infection were treated with omeprazole 20 mg b.d., tetracycline chlorhydrate 500 mg t.d.s., metronidazole 500 mg t.d.s., and bismuth subcitrate 120 mg t.d.s. administered with meals for 7 days. Cure was tested by either endoscopy or breath test after 2 months, and by urea breath test 6 months after therapy. Results: Seven patients were lost to follow‐up. Of the remaining 115, 110 were cured at the first control, giving an intention‐to‐treat cure rate of 90.2% (95% CI: 83–95%) and a per protocol cure rate of 95.7% (95% CI: 90–98%). One hundred three patients returned for a 6‐month breath test; all but one were cured. Side‐effects were minimal or minor in 47 patients (40.8%) and moderate in four (3.4%). Compliance was good, 95% of patients taking more than 90% of the pills. Six (5%) patients stopped treatment after 1, 2, 4 (two patients) and 6 (two patients) days. Conclusion: Thrice a day quadruple therapy shows excellent cure rates, far above 90%, is well‐tolerated and compliance is easy. Head‐to‐head comparison with triple therapies as first line Helicobacter pylori treatment seems warranted.

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Long‐term follow‐up after cure of Helicobacter pylori infection with 4 days of quadruple therapy

Abstract: Four days of quadruple therapy seems to be an effective therapy for the eradication of H. pylori as evidenced after long-term follow-up. Our biopsy methodology is reliable in identifying treatment failures 5-6 weeks post-treatment.

Cited by 21 publications

References 0 publications

Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment

Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment

Comparison of two 3‐day Helicobacter pylori eradication regimens with a standard 1‐week regimen

Modified seven‐day, quadruple therapy as a first line Helicobacter pylori treatment

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