Long-term fluoride therapy of postmenopausal osteoporosis

Ma, Dambacher; Ittner, J.; Rüegsegger, P.

doi:10.1016/8756-3282(86)90018-9

Cited by 74 publications

(19 citation statements)

References 11 publications

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“…NaF is so far the most potent stimulator of bone formation that has been used clinically (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)45). In spite of clearcut increases in bone mass, the effect of fluoride treatment on osteoporotic fractures is equivocal.…”

Section: Discussionmentioning

confidence: 99%

Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.

Lafage

Balena²,

Battle³

et al. 1995

J. Clin. Invest.

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Fluoride stimulates trabecular bone formation, whereas bisphosphonates reduce bone resorption and turnover. Fracture prevention has not been convincingly demonstrated for either treatment so far. We compared the effects of 1-yr treatment of 9-mo-old minipigs with sodium fluoride (NaF, 2 mg/kg/d p.o.) or alendronate (ALN, 4 amino-l-hydroxy-on the biomechanical and histomorphometric properties of pig bones. As expected, NaF increased and ALN decreased bone turnover, but in these normal animals neither changed mean bone volume. NaF reduced the strength of cancerous bone from the LA vertebra, relative to control animals, and the stiffness (resistance to deformation) of the femora, relative to the ALN group. In the ALN-treated animals, there was a strong positive correlation between bone strength and L5 cancerous bone volume, but no such correlation was observed in the NaF group. Furthermore, the modulus (resistance to deformation of the tissue) was inversely related to NaF content and there was a relative decrease in bone strength above 0.25 mg NaF/g bone. Moreover, within the range of changes measured in this study, there was an inverse correlation between bone turnover, estimated as the percentage of osteoid surface, and modulus. These findings have relevant implications regarding the use of these agents for osteoporosis therapy. (J. Clin. Invest. 1995. 95:2127-2133

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Section: Discussionmentioning

confidence: 99%

Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.

Lafage

Balena²,

Battle³

et al. 1995

J. Clin. Invest.

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show abstract

“…However, this finding was not supported in another study [330], where 7 of 15 (47%) subjects treated with 80 mg of a different slow-release sodium fluoride preparation reported pain and swelling in their lower extremities, causing them to temporarily discontinue treatment. In addition to the higher dose of fluoride, subjects in this trial did not receive supplemental calcium.…”

Section: Fluoridementioning

confidence: 84%

Osteoporosis: Review of the Evidence for Prevention, Diagnosis and Treatment and Cost-Effective Analysis

1998

Osteoporos Int

110

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“…The instrumentation allowed monitoring of very small changes in density of the appendicular trabecular bone. Subsequent work confirmed the value of the method to monitor very small changes of bone mineral mass in short periods of time either pharmacologcally induced [25][26][27] or due to disease [28][29][30][31]. Some investigations have documented the value of pQCT in comparison to other densitometric methods [n, 12,32].…”

Section: Clinical Evaluation Of the Pqct Technologymentioning

confidence: 87%

Peripheral Quantitative Computed Tomography

Schneider¹,

Reiners²

1998

Bone Densitometry and Osteoporosis

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Access to measurement of bone density by absorptiometry has been limited to planar information due to its ability to deliver only projections of the bones that are investigated. Some researchers realized this lack of capability of the available techniques and tried to develop systems offering three-dimensional information. The aim was to provide a view inside the bone into the spongiosa compartment, which is known to have a high turnover. It was expected to see changes in bone mass occurring earlier in this compartment than in compact bone or in a projected mixture of trabecular and compact bone.The first attempt at developing a method capable of three-dimensional evaluation of bones was done at the University ofWurzburg in 1969 [1]. It was a simple profile scanner, taking perpendicular profiles of the midphalanx and assuming an elliptical shape based on the main ellipsoid axes. The scanner used an 12 51 photon source. A further and more sophisticated attempt was published in the Proceedings of the International Conference on Bone Mineral Measurement 1973 in Chicago [2], when Ruegsegger and coworkers described an iterative method which came very close to computed tomography as proposed by Hounsfield [3].A few years later the group had developed a 12 51 based system offering true computed tomographic images at a higher resolution than the conventional systems available [4]. This has led to much interest and to several derivatives for research purposes [5][6][7][8][9]. In the early 1980s a simple device was developed in Wurzburg following the profile finger-scanner method. The system was able to perform translate-rotate scans at very variable parameter settings. An approach similar to Ruegsegger's first method produced a least-squares algorithm for the contour detection oflong bones [10].We have favored the use of small computer units in order to make such systems affordable for a large community of scientists and physicians. Due to the constantly increasing power of personal computers we were soon able to handle the large amount of operations required for the calculation of backprojected computer tomographic images. With a system similar to Ruegsegger's 12 51 based scanner we achieved first clinical results in comparison to the conventional techniques of single-photon (SPA) and dual-photon absorptiometry (DPA) [11]. Sensitivity and specificity of the prototype system for peripheral quantitative computed tomography (pQCT) was acceptable but not superior to those of the other tech- H. K. Genant et al. (eds.), Bone Densitometry and Osteoporosis

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Long-term fluoride therapy of postmenopausal osteoporosis

Cited by 74 publications

References 11 publications

Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.

Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.

Osteoporosis: Review of the Evidence for Prevention, Diagnosis and Treatment and Cost-Effective Analysis

Peripheral Quantitative Computed Tomography

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