Long-Term Field Trials with the Herpesvirus of Turkeys Vaccine against Marek's Disease

Purchase, H. G.; Okazaki, W.; Br, Burmester

doi:10.2307/1588900

Cited by 75 publications

(28 citation statements)

References 9 publications

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“…Altogether, our results suggest that ENR can exert its dichotomous effect on microsomal enzymes in HVT-vaccinated chickens in a dose-dependent manner, and inhibition of the two enzymes, in the vaccinated groups, appears to have been a consequence either of viral replication because the vaccinal virus persists and replicates for a prolonged time (Purchase et al, 1972), or of HVT-induced cytokines.…”

Section: Discussionmentioning

confidence: 70%

Marek's disease vaccination, with turkey herpesvirus, and enrofloxacin modulate the activities of hepatic microsomal enzymes in broiler chickens

Sakar

Prukner‐Radovčić

Crnić

et al. 2004

Acta Veterinaria Hungarica

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Chickens were vaccinated against Marek's disease intramuscularly at one day of age. Enrofloxacin was given ad libitum in the drinking water at concentrations of 50, 100 and 250 mg/L from 8 days to 13 days of age when the animals were killed and the activities of cytochrome P-450 enzymes in the liver were measured. Vaccinated non-treated chickens served as a positive control. A negative control group was neither vaccinated nor treated. Vaccination decreased the activity of aniline hydroxylase and ethylmorphine N-demethylase in the positive control group. Subsequent application of enrofloxacin in the lowest concentration (50 mg/L) decreased, while that given at the highest level (250 mg/L) significantly increased the activity of the same microsomal enzymes. Relative liver weights and concentrations of proteins in 9000 × g supernatant were not affected by vaccination or treatment.

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Section: Discussionmentioning

confidence: 70%

Marek's disease vaccination, with turkey herpesvirus, and enrofloxacin modulate the activities of hepatic microsomal enzymes in broiler chickens

Sakar

Prukner‐Radovčić

Crnić

et al. 2004

Acta Veterinaria Hungarica

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“…HVT, classified as serotype 3, is nononcogenic in chickens and only mildly infectious, causing an inapparent infection (Payne, 1982). The viruses are related serologically and HVT has been used as an effective vaccine against MDV (Purchase et al, 1972). Cross-hybridization studies have shown that their genomes are collinear (Igarashi et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Gene Sequence and Mapping Data from Marek's Disease Virus and Herpesvirus of Turkeys: Implications for Herpesvirus Classification

Buckmaster¹,

Scott²,

Sanderson³

et al. 1988

Journal of General Virology

165

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SUMMARYPurified DNAs from Marek's disease virus (MDV) and the herpesvirus of turkeys (HVT) were randomly sheared and cloned into the M 13 bacteriophage. Two-hundred and ten MDV and 130 HVT clones were sequenced to give representative samples of the genome sequences. The predicted amino acid sequences from these gammaherpesviruses were compared to known sequences from other herpesviruses using computer analysis. Thirty-five MDV and 24 HVT genes were identified by comparison with varicella-zoster virus (VZV), an alphaherpesvirus. However, only 14 MDV and seven HVT genes, giving generally lower homology scores, were found by comparison with Epstein-Barr virus (EBV), a gammaherpesvirus, indicating that MDV and HVT sequences bear greater similarity to VZV than to EBV sequences. A number of sequences were mapped by hybridizing labelled M13 clones to Southern blots of restriction fragments of MDV or HVT DNA. The results were consistent with the MDV and HVT genomes being collinear with VZV.

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“…In previous studies, two prominent antigenic glycoproteins, the A antigen (A Ag; gp57-65) and the B antigen (gpl00, 60, 49), were reported to be shared by pathogenic and non-pathogenic viruses (Okazaki et al, 1970;Witter et al, 1970;Purchase et al, 1972;Velicer et al, 1978;Ikuta et al, 1983Ikuta et al, , 1984. Of these antigens, the A Ag is the major antigenic protein produced in and secreted from infected cells during infection (Churchill et al, 1969;Van Zaane et al, 1982;Ikuta et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

“…Live vaccines developed from antigenically related but non-pathogenic viruses are used in the prevention of this disease (Okazaki et al, 1970;Purchase et al, 1972). The mechanisms of prevention of MD by live vaccines have been extensively studied as it is one of a few diseases induced by viruses, which result in tumour formation, that can be prevented by vaccination.…”

Section: Introductionmentioning

confidence: 99%

Expression of the A antigen (gp57-65) of Marek's disease virus by a recombinant baculovirus

Niikura

Matsuura²,

Hattori³

et al. 1991

Journal of General Virology

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A recombinant baculovirus expressing the A antigen (A Ag) of Marek's disease virus (MDV) was constructed. In Spodoptera fruiperda (Sf) cells infected with the recombinant virus, A Ag expression was localized to the cell surface. Only a small amount of recombinant A Ag was detected in the culture supernatant of infected Sfcells, but authentic A Ag is mainly secreted into the culture supernatant of MDV-infected chicken embryo fibroblasts. Cell surface-associated recombinant A Ag seemed to be slightly larger than authentic A Ag, whereas the secreted recombinant A Ag seemed to be smaller. The recombinant A Ag was shown to be reactive with the sera of MDV-infected chickens by immunodiffusion studies and ELISA. Sera of chickens immunized with recombinant A Ag formed a precipitin line with the culture supernatant of MDV-infected chicken embryo fibroblasts in an immunodiffusion test. These results indicate that the recombinant A Ag expressed by the recombinant baculovirus retains the antigenic and immunogenic properties of the authentic A Ag.

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Long-Term Field Trials with the Herpesvirus of Turkeys Vaccine against Marek's Disease

Cited by 75 publications

References 9 publications

Marek's disease vaccination, with turkey herpesvirus, and enrofloxacin modulate the activities of hepatic microsomal enzymes in broiler chickens

Marek's disease vaccination, with turkey herpesvirus, and enrofloxacin modulate the activities of hepatic microsomal enzymes in broiler chickens

Gene Sequence and Mapping Data from Marek's Disease Virus and Herpesvirus of Turkeys: Implications for Herpesvirus Classification

Expression of the A antigen (gp57-65) of Marek's disease virus by a recombinant baculovirus

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