Long-Term Exposure to Ultrafine Particles and Particulate Matter Constituents and the Risk of Amyotrophic Lateral Sclerosis

Yu, Zhebin; Peters, Susan; Boxmeer, Loes van; Downward, George S.; Hoek, Gerard; Kioumourtzoglou, Marianthi-Anna; Weisskopf, Marc G.; Hansen, Johnni; Berg, Leonard H. van den; Vermeulen, Roel

doi:10.1289/ehp9131

Cited by 13 publications

(19 citation statements)

References 11 publications

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“…PM 2.5 absorbance and NO 2 remained significant after adjusting additionally for urbanization degree and showed linear trends ( p = 0.002 and 0.03, respectively). Such findings were also observed in a follow-up research letter to this Dutch study ( 60 ). Additional analyses included further analysis of PM 2.5 and particulate matter (PM 10 ) elemental fractions of road traffic non-tail pipe emissions, which were associated with significantly higher ORs for ALS in copper, iron, nickel, sulfur, silicon (Si) and vanadium particulate and fine particulate elemental constituents.…”

Section: Resultssupporting

confidence: 83%

“…Ultrafine particles were not associated with ALS. In both the original study and the follow-up research letter, PM 10 itself was not associated with the odds of ALS ( 36 , 60 ); a finding which was also reported in a small case-control study in Italy ( 59 ).…”

Section: Resultssupporting

confidence: 53%

“…Overall, many high-quality studies, all using a case-control design and accounting for various factors, identified a positive association between residential exposure to atmospheric pollutants and the odds of ALS. NO 2 was not only significantly associated with increased odds of ALS in all three papers that studied this pollutant ( 36 , 39 , 60 ), but also showed a dose-response with an increasing gradient for the OR of ALS as the quartile of exposure increased ( 39 ). There is strong evidence for NO 2 as a potential risk factor for ALS.…”

Section: Resultsmentioning

confidence: 88%

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Urbanization, air pollution, and water pollution: Identification of potential environmental risk factors associated with amyotrophic lateral sclerosis using systematic reviews

Saucier

Registe²,

Bélanger³

et al. 2023

Front. Neurol.

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IntroductionDespite decades of research, causes of ALS remain unclear. To evaluate recent hypotheses of plausible environmental factors, the aim of this study was to synthesize and appraise literature on the potential associations between the surrounding environment, including urbanization, air pollution and water pollution, and ALS.MethodsWe conducted a series (n = 3) of systematic reviews in PubMed and Scopus to identify epidemiological studies assessing relationships between urbanization, air pollution and water pollution with the development of ALS.ResultsThe combined search strategy led to the inclusion of 44 articles pertaining to at least one exposure of interest. Of the 25 included urbanization studies, four of nine studies on living in rural areas and three of seven studies on living in more highly urbanized/dense areas found positive associations to ALS. There were also three of five studies for exposure to electromagnetic fields and/or proximity to powerlines that found positive associations to ALS. Three case-control studies for each of diesel exhaust and nitrogen dioxide found positive associations with the development of ALS, with the latter showing a dose-response in one study. Three studies for each of high selenium content in drinking water and proximity to lakes prone to cyanobacterial blooms also found positive associations to ALS.ConclusionWhereas markers of air and water pollution appear as potential risk factors for ALS, results are mixed for the role of urbanization.

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Section: Resultssupporting

confidence: 83%

Section: Resultssupporting

confidence: 53%

Section: Resultsmentioning

confidence: 88%

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Urbanization, air pollution, and water pollution: Identification of potential environmental risk factors associated with amyotrophic lateral sclerosis using systematic reviews

Saucier

Registe²,

Bélanger³

et al. 2023

Front. Neurol.

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“…51 Finally, a recent cohort study found an association between ALS clinical diagnosis and various metals from road traffic non-tailpipe emissions. 52 Overall, previous findings suggest that some traffic-related pollutants may be relevant to ALS diagnosis and aggravation. Our work complements previous studies by providing effect estimates for major PM 2.5 components, some of which were not evaluated previously.…”

Section: Discussionmentioning

confidence: 88%

“…For example, metals account for a small percentage of total PM 2.5 mass and were not evaluated in this study but were previously linked to neurodegenerative diseases. 52,66,67 Additionally, we analyzed OM's total particulate mass but OM is itself a mixture and includes multiple chemical compounds. We also did not evaluate potential interactions or additive effects among the components, which could play a role in the overall PM 2.5 neurotoxicity.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

PM2.5 composition and disease aggravation in amyotrophic lateral sclerosis

Nunez

Boehme

Goldsmith

et al. 2022

Environmental Epidemiology

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Background: Long-term exposure to fine particulate matter (PM 2.5 ) has been associated with disease aggravation in amyotrophic lateral sclerosis (ALS). In this study, we characterized long-term exposure to six major PM 2.5 components and their individual association with disease aggravation in ALS. Methods: We leveraged 15 years of data from the New York Department of Health Statewide Planning and Research Cooperative System (2000-2014) to calculate annual ALS first hospitalizations in New York State. We used the first hospital admission as a surrogate of disease aggravation and a prediction model to estimate population-weighted annual black carbon, organic matter (OM), nitrate, sulfate, sea salt, and soil concentrations at the county level. We used a multi-pollutant mixed quasi-Poisson model with county-specific random intercepts to estimate rate ratios (RR) of 1-year exposure to each PM 2.5 component and disease aggravation in ALS, adjusting for potential confounders. Results: We observed 5,655 first ALS-related hospitalizations. The annual average hospitalization count per county was 6.08 and the average PM 2.5 total mass concentration per county was 8.1 μg/m 3 -below the United States' National Ambient Air Quality Standard of 12 μg/m 3 . We found a consistent positive association between ALS aggravation and OM (1.17, 95% confidence intervals [CI], 1.11, 1.24 per standard deviation [SD] increase) and a negative association with soil (RR = 0.91, 95% CI, 0.86, 0.97). Conclusion: Our findings suggest that PM 2.5 composition may influence its effect on ALS. We found that annual increases in county-level particulate OM may be associated with disease aggravation in ALS, even at PM 2.5 levels below current standards.

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Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions

Sakowski,

Koubek,

Chen

et al. 2024

Annals of Neurology

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Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes are multifactorial and complex, and increasing evidence suggests a dynamic interplay between genes and the environment, emphasizing the importance of identifying and understanding the role of lifelong exposures, known as the exposome, on the nervous system. This review provides an overview of recent advances toward defining neurodegenerative disease exposomes, focusing on Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. We present the current state of the field based on emerging data, elaborate on key themes and potential mechanisms, and conclude with limitations and future directions. ANN NEUROL 2024

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Long-Term Exposure to Ultrafine Particles and Particulate Matter Constituents and the Risk of Amyotrophic Lateral Sclerosis

Cited by 13 publications

References 11 publications

Urbanization, air pollution, and water pollution: Identification of potential environmental risk factors associated with amyotrophic lateral sclerosis using systematic reviews

Urbanization, air pollution, and water pollution: Identification of potential environmental risk factors associated with amyotrophic lateral sclerosis using systematic reviews

PM2.5 composition and disease aggravation in amyotrophic lateral sclerosis

Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions

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