Long-term exposure to indoor air pollution and wheezing symptoms in infants

Raaschou-Nielsen, Ole; Hermansen, Mette Northman; Loland, Lotte; Buchvald, Frederik; Pipper, Christian Bressen; Sørensen, Mette; Loft, Steffen; Bisgaard, Hans

doi:10.1111/j.1600-0668.2009.00635.x

Cited by 37 publications

(43 citation statements)

References 52 publications

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“…The majority (n=45) of studies employed observational designs. There were six cohort studies [31][32][33][34][35][36] and 11 case-control studies [37][38][39][40][41][42][43][44][45][46][47]. Among the observational studies, two-thirds (n=28) were cross-sectional studies .…”

Section: Resultsmentioning

confidence: 99%

“…Five studies, including one RCT [23], three cohort studies [33][34][35] and one case-control study [47], were graded as being at low risk of bias; 15 studies, including two cohort studies [31,36], five case-control studies [37,[42][43][44][45] and eight cross-sectional studies [48,50,62,65,[72][73][74][75], were graded as being at moderate risk of bias. The remaining 33 studies were judged to be at high risk of bias (tables S1 and S1A).…”

Section: Quality Assessmentmentioning

confidence: 99%

“…One RCT with low risk of bias reported adverse associations between formaldehyde and wheezing [23]. One cohort study at low risk of bias found no associations between formaldehyde and wheezing [34]; in contrast, one case-control at low risk of bias [47] and two cross-sectional studies at moderate risk of bias [74,75] showed positive associations between formaldehyde and current asthma severity, wheezing/severity and nocturnal breathlessness (table S1A).…”

Section: Aldehydesmentioning

confidence: 99%

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Volatile organic compounds and risk of asthma and allergy: a systematic review

et al. 2015

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Volatile organic compounds (VOCs) are ubiquitous domestic pollutants. Their role in asthma/allergy development and exacerbations is uncertain. This systematic review investigated whether domestic VOC exposure increases the risk of developing and/or exacerbating asthma and allergic disorders.We systematically searched 11 databases and three trial repositories, and contacted an international panel of experts to identify published and unpublished experimental and epidemiological studies.8455 potentially relevant studies were identified; 852 papers were removed after de-duplication, leaving 7603 unique papers that were screened. Of these, 278 were reviewed in detail and 53 satisfied the inclusion criteria. Critical appraisal of the included studies indicated an overall lack of high-quality evidence and substantial risk of bias in this body of knowledge. Aromatics (i.e. benzenes, toluenes and xylenes) and formaldehyde were the main VOC classes studied, both in relation to the development and exacerbations of asthma and allergy. Approximately equal numbers of studies reported that exposure increased risks and that exposure was not associated with any detrimental effects.The available evidence implicating domestic VOC exposure in the risk of developing and/or exacerbating asthma and allergy is of poor quality and inconsistent. Prospective, preferably experimental studies, investigating the impact of reducing/eliminating exposure to VOC, are now needed in order to generate a more definitive evidence base to inform policy and clinical deliberations in relation to the management of the now substantial sections of the population who are either at risk of developing asthma/ allergy or living with established disease. @ERSpublications Investigation of VOCs in relation to developing or exacerbating asthma or allergy indicates new studies are required

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Section: Resultsmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

Section: Aldehydesmentioning

confidence: 99%

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Volatile organic compounds and risk of asthma and allergy: a systematic review

et al. 2015

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“…One of the few studies to examine infants’ exposure in to indoor air pollution in homes in an industrialized country measured long-term exposure to NO x , NO 2 , formaldehyde, PM 2.5 , and black smoke in homes of 411 infants in Denmark, finding no association with risk of wheezing [55]. Raaschou-Nielsen et al .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Indoor Air Pollution in Homes with Infants

Pickett

Bell

2011

IJERPH

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Infants spend most of their indoor time at home; however, residential air quality is poorly understood. We investigated the air quality of infants’ homes in the New England area of the U.S. Participants (N = 53) were parents of infants (0–6 months) who completed telephone surveys to identify potential pollutant sources in their residence. Carbon monoxide (CO), carbon dioxide (CO2), particulate matter with aerodynamic diameter ≤0.5 µm (PM0.5), and total volatile organic compounds (TVOCs) were measured in 10 homes over 4–7 days, and levels were compared with health-based guidelines. Pollutant levels varied substantially across homes and within homes with overall levels for some homes up to 20 times higher than for other homes. Average levels were 0.85 ppm, 663.2 ppm, 18.7 µg/m3, and 1626 µg/m3 for CO, CO2, PM0.5, and TVOCs, respectively. CO2, TVOCs, and PM0.5 levels exceeded health-based indoor air quality guidelines. Survey results suggest that nursery renovations and related potential pollutant sources may be associated with differences in urbanicity, income, and presence of older children with respiratory ailments, which could potentially confound health studies. While there are no standards for indoor residential air quality, our findings suggest that additional research is needed to assess indoor pollution exposure for infants, which may be a vulnerable population.

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“…In both urban and rural environments, this study (32) demonstrated that exposure to acetaldehyde and toluene was significantly associated with a higher risk of asthma (OR: 2.73, 95% CI: 1.28 -5.83, and OR: 2.15, 95% CI: 1.01-4.58, respectively). A long-term study of an infant cohort by Raaschou-Nielsen et al (58) explored the effects of exposure to indoor air pollution and wheezing, a symptom that may progress into asthma later in life. This study did not demonstrate a systematic association between the risk for wheezing symptoms and levels of indoor air pollutants.…”

Section: Indoor Air Pollutionmentioning

confidence: 99%