Long-term exposure to environmentally relevant concentrations of ibuprofen and aluminum alters oxidative stress status on Danio rerio

Metabolomic‐Based Comparison of Daphnia magna and Japanese Medaka Responses After Exposure to Acetaminophen, Diclofenac, and Ibuprofen

“…Overall, the biochemical pathway analysis revealed disturbances to pathways associated with protein regulation and amino acid metabolism in D. magna exposure to ACT, DCF, and IBU and medaka exposure to DCF, which is consistent with previous studies with the selected analgesics using different model organisms (Gao et al, 2019;Hallare et al, 2004;Islas-Flores et al, 2017;Tiwari et al, 2020). Other studies using a range of organisms have also reported some of the distinct responses observed in our study (Bartoskova et al, 2013;Gutiérrez-Noya et al, 2020;Lari et al, 2022;Sánchez-Aceves et al, 2021). For example, previous studies with different aquatic species also documented disruptions to alanine, aspartate, and glutamate metabolism with ACT exposure (Lari et al, 2022) and to antioxidant processes with IBU exposure (Bartoskova et al, 2013;Gutiérrez-Noya et al, 2020;Sánchez-Aceves et al, 2021).…”

“…Thus we hypothesized that the selected analgesics would alter the metabolic profiles of adult D. magna and adult medaka differently as a reflection of various different pollutant sensitivities between these two species. In addition, similarities and differences in metabolite disruption are compared with previous reports on impairments elicited by exposure to the selected analgesics (Lari et al, 2022;Oliveira et al, 2015;Sánchez-Aceves et al, 2021).…”

Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen

“…The most interesting information was about the state of cells on day 4 of the experiment, which was associated with the active process of IBP bioconversion and accumulation of its transformation products in the culture medium. As shown in Table 7, in the first days of the experiment, there was a decrease in the cell length (p<0.05) and surface area (p<0.01) in the presence of IBP compared to control variants, but there was an increase (not significant) in the root-mean-square roughness of the cell surface (Table 7 and Fig 6). On the fourth day, the cells significantly changed their shapes due to shortening of the length (by 1.5 times) and increasing of the width (by 1.7 times) (Table 7 and Figs 7 and S12).…”

“…In terms of scale and environmental significance, the problem of pharmaceutical pollution is now becoming genuinely planetary [3][4][5]. Pharmaceutical pollutants have harmful effects on the environment, causing high toxicity even in environmentally relevant concentrations [6][7][8]. Understanding the mechanisms of biological transformation of pharmaceuticals is essential for determining their ecological fate and approaches for effective neutralization.…”

“…In this regard, IBP is prone to bioaccumulate in marine [36,37] and freshwater [38][39][40] molluscs, fish [41,42], mammals [43], plants [44] and to biomagnificate in food chains [38,45]. Accumulating in the body of vertebrates and invertebrates, IBP causes negative effects, such as oxidative stress, DNA damage, suppression of individual enzyme activities (e.g., nitration of proteins), disruption of mitochondria, and lipid peroxidation [6,16,[46][47][48][49]. The toxicity of IBP to lower and higher plants is described in a few studies [48,50].…”