Long-term exposure to air pollution might decrease bone mineral density T-score and increase the prevalence of osteoporosis in Hubei province: evidence from China Osteoporosis Prevalence Study

Zhang, Faxue; Zhou, Fang; Líu, Hao; Zhang, Xupeng; Zhu, Shijie; Zhang, Xiaowei; Zhao, Gaichan; Li, Dejia; Zhu, Wei

doi:10.1007/s00198-022-06488-7

Cited by 24 publications

(11 citation statements)

References 56 publications

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“…This study—with >9000 women participating in WHI and >30,000 visits—supports ours 8 and other findings 10 , 16 , 34 , 35 , 36 of an association between air pollution and bone damage in postmenopausal women. This association was independent of socioeconomic, geographic, and lifestyle factors.…”

Section: Discussionsupporting

confidence: 89%

“…suggested that long-term exposure to PM 2.5 was associated with decreased BMD T-score and increased osteoporosis risk among participants from rural areas of China. 16 However, to our knowledge, no studies have prospectively determined the impact of criteria air pollutants and their mixtures on bone mineral density (BMD) in postmenopausal women in the US. The goal of this study was to determine the influence of four criteria air pollutants and their mixtures on bone mineral density in a large, geographically, and ethnically diverse population of US postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

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Air pollution and decreased bone mineral density among Women's Health Initiative participants

Prada¹,

Crandall²,

Kupsco³

et al. 2023

eClinicalMedicine

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Air pollution and decreased bone mineral density among Women's Health Initiative participants

Prada¹,

Crandall²,

Kupsco³

et al. 2023

eClinicalMedicine

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“…Previous studies have explored the relationship between air pollution and osteoporosis. Evidence suggests that long-term exposure to PM 2.5 is associated with a decreased bone mineral density (BMD) and an increased risk of osteoporosis ( 16 ) and osteoporotic fracture ( 17 ). Long-term exposure to PM 10 was linked to newly diagnosed osteoporosis in Korean adults ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Risk of ozone exposure-induced fracture

Lü

Gong

et al. 2023

Front. Public Health

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IntroductionOzone (O3) is known to induce oxidative stress that influences various cells and tissues, which may further lead to diminished bone mineral density. Nevertheless, few studies have investigated the association between O3 exposure and fractures. Considering the similar growing trends of O3 concentrations and fracture morbidity in recent years, in the present study, we aimed to examine whether O3 exposure is associated with the fracture morbidity.MethodsUsing a retrospective cohort study design, we analyzed the records of 8,075 patients with fracture admitted in the warm season to Beijing Jishuitan Hospital from 2014 to 2019 and matched them to the corresponding exposure time and concentration of O3.ResultsThe results showed that increased odds of fracture were associated with increased O3 concentrations, presumably because O3 induces oxidative stress (OS) that leads to bone mineral density (BMD) loss.DiscussionOur findings suggest that O3 exposure is a risk factor for fractures, providing new evidence of the adverse health effect induced by air pollution. We can conclude that more intensive air pollution control is needed for the prevention of fracture occurrence.

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“…[16][17][18] Long-term exposure to air pollution is inversely associated with bone health, such as diminished bone density, increased risk of osteoporosis and greater susceptibility to fracture. [19][20][21][22] In light of these findings, it is crucial to investigate the association between greenness and incident fracture and to prioritize efforts to create healthier environments for residents. However, to date, limited studies have been available to investigate the association of greenness and walkability with fracture.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Neighborhood Walkability and Residential Greenness and Incident Fracture

Zhu,

Yang,

et al. 2023

JAMA Netw Open

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ImportanceEmerging studies have suggested that environmental factors are associated with fracture. However, little is known about the association of neighborhood walkability and residential greenness with fracture.ObjectiveTo investigate the association of long-term exposure to walkability and greenness with incident fracture and explore the potential interaction effect.Design, Setting, and ParticipantsThis cohort study recruited participants aged 40 years or older in Ningbo, China from June 2015 to January 2018. Participants were observed for outcomes through February 2023, with data analysis conducted in March 2023.ExposuresNeighborhood walkability was measured by a modified walkability calculation method according to a walk score tool. Residential greenness was assessed by satellite-derived normalized difference vegetation index (NDVI) within a 1000-m buffer.Main Outcomes and MeasuresIncident fracture was ascertained according to International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes via the Yinzhou Health Information System. Cox proportional hazards models were fit, with age as time scale to estimate the associations of walkability and greenness with fracture. Potential effect modification was explored by covariates, as well as the interactive effect of walkability and greenness.ResultsA total of 23 940 participants were included in this study with 13 735 being female (57.4%). The mean (SD) age at baseline was 63.4 (9.4) years. During a follow-up period of 134 638 person-years, 3322 incident fractures were documented. In the full adjusted model, every IQR increment in neighborhood walkability and residential greenness was associated with a hazard ratio (HR) of 0.88 (95% CI, 0.83-0.92) and 0.84 (95% CI, 0.80-0.89), respectively, for fracture. Furthermore, the association of greenness and fracture was greater with an increase in walkability. The HR (Q4 vs Q1) for greenness was 0.62 (95% CI, 0.46-0.82) in neighborhoods with the highest quartile of walkability.Conclusions and RelevanceThis population cohort study suggested that long-term exposure to neighborhood walkability and residential greenness were both associated with lower risk of incident fracture. The benefits of greenness increased in more walkable areas.

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Long-term exposure to air pollution might decrease bone mineral density T-score and increase the prevalence of osteoporosis in Hubei province: evidence from China Osteoporosis Prevalence Study

Cited by 24 publications

References 56 publications

Air pollution and decreased bone mineral density among Women's Health Initiative participants

Air pollution and decreased bone mineral density among Women's Health Initiative participants

Risk of ozone exposure-induced fracture

Exposure to Neighborhood Walkability and Residential Greenness and Incident Fracture

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