Long-term exposure to air pollution might increase prevalence of osteoporosis in Chinese rural population

Qiao, Dou; Pan, Jianwen; Chen, Gongbo; Xiang, Hao; Tu, Runqi; Zhang, Xia; Dong, Xiaokang; Wang, Yan; Luo, Zhicheng; Tian, Huiling; Mao, Zhenxing; Huo, Wenqian; Zhang, Gongyuan; Li, Shanshan; Lee, Hyewon; Wang, Chongjian

doi:10.1016/j.envres.2020.109264

Cited by 44 publications

(54 citation statements)

References 49 publications

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“…Thus, it is important to have a further investigation on the relationship between environmental pollutants and genetic factors which may affect disease susceptibility [6]. However, there requires a caution in interpretation of the data that no significant increase in risk is limited to CKD only since other diseases, such as stroke, ischemic heart disease, COPD, asthma, and osteoporosis, were previously reported to be significantly affected by exposure to the air pollution [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Association of Air Pollutants with Incident Chronic Kidney Disease in a Nationally Representative Cohort of Korean Adults

Hwang

Jeong

Choi

et al. 2021

IJERPH

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(1) Background: There is limited information regarding association between long-term exposure to air pollutants and risk of chronic kidney disease (CKD) (2). Methods: This study acquired data of 164,093 adults aged at least 40 years who were residing in 7 metropolitan cities between 2002 and 2005 from the Korean National Health Insurance Service National Sample Cohort database. CKD risk was evaluated using the multivariate Cox hazards proportional regression. All participants were followed up with until CKD, death, or 31 December 2013, whichever occurred earliest. (3) Results: Among 1,259,461 person-years of follow-up investigation, CKD cases occurred in 1,494 participants. Air pollutant exposures including PM10, SO2, NO2, CO, and O3 showed no significant association with incident CKD after adjustments for age, sex, household income, area of residence, and the Charlson comorbidity index. The results were consistent in the sensitivity analyses including first and last year annual exposure analyses as well as latent periods-washed-out analyses. (4) Conclusions: Long-term exposure to air pollution is not likely to increase the risk of CKD.

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Section: Discussionmentioning

confidence: 99%

Association of Air Pollutants with Incident Chronic Kidney Disease in a Nationally Representative Cohort of Korean Adults

Hwang

Jeong

Choi

et al. 2021

IJERPH

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“… NS association between BMD T-score and PM 2.5 [β= −0.002; 95% CI (−0.006, 0.002); p= 0.311] and PM 10 [β= 0.001; 95% CI (−0.002, 0.004); p= 0.491] after adjusting for age, sex, smoking history, diabetes, hypertension, BMI, systolic blood pressure, diastolic blood pressure, fasting glucose, triglyceride, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, haemoglobin, estimated glomerular filtration rate, uric acid, and regular exercise. 7 Qiao et al 2020 87 July 2015- Sept 2017 (based on Henan Rural Cohort study) Five rural regions (Suiping county, Yuzhou county, Xinxiang county, Tongxu county and Yima county) of Henan province, China Cross-sectional study 8033 subjects with men (n=3001) and women (n= 5032) aged 55.8 ± 10.8 years old 3-year average PM 1 , PM 2.5 and PM 10 levels were estimated using machine learning algorithms (random forests model) with satellite remote sensing, land use information, and meteorological data Bone health of the non-dominant foot by QUS Followed WHO definition of osteoporosis Osteoporosis risk were positively associated with PM 1 [56.5–57.7 μg/m 3 : OR= 1.068, 95% CI= (1.357, 1.907); >57.7 μg/m 3 : OR= 2.075, 95% CI= (1.724, 2.497)], PM 2.5 [>73.2 μg/m 3 : OR= 2.280, 95% CI= (1.899, 2.738)] and PM 10 [128.3–133.0 μg/m 3 : OR= 1.770, 95% CI= (1.492, 2.100); >133.0 μg/m 3 : OR= 1.929, 95% CI= (1.602, 2.322)] after adjusting for age, sex, education level, marital status, smoking, drinking, physical activity, dietary habits, and region. PM 1 , PM 2.5 and PM 10 (for each 1 μg/m 3 increase) were associated with a 14.9%, 14.6% and 7.3% higher risk of osteoporosis.…”

Section: Methodsmentioning

confidence: 99%

Particulate Air Pollution and Osteoporosis: A Systematic Review

Pang

Ekeuku

Chin

2021

RMHP

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Air pollution is associated with inflammation and oxidative stress, which predispose to several chronic diseases in human. Emerging evidence suggests that the severity and progression of osteoporosis are directly associated with inflammation induced by air pollutants like particulate matter (PM). This systematic review examined the relationship between PM and bone health or fractures. A comprehensive literature search was conducted from January until February 2021 using the PubMed, Scopus, Web of Science, Google Scholar and Cochrane Library databases. Human cross-sectional, cohort and case–control studies were considered. Of the 1500 papers identified, 14 articles were included based on the inclusion and exclusion criteria. The air pollution index investigated by most studies were PM 2.5 and PM 10 . Current studies demonstrated inconsistent associations between PM and osteoporosis risk or fractures, which may partly due to the heterogeneity in subjects’ characteristics, study design and analysis. In conclusion, there is an inconclusive relationship between osteoporosis risk and fracture and PM exposures which require further validation.

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“…Evidence suggests that there are adverse effects of AP on osteoporosis among the industrial population. 25 By contrast, the total running distance and frequency rank are considered beneficial to body mass density (BMD). 26 However, a high total running distance and frequency has been shown to cause BMD impairment, particularly in the lumbar spine region.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…27 28 Therefore, the effect of AP and regular running on the development of osteoporosis can depend on overall running volume, with a potential U risk curve. Qiao et al 25 suggests that physical activity, such as running, may weaken the adverse effects of AP on osteoporosis. However, it is not clear whether regular running is beneficial to bone health, independent of ambient AP.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Regular running in an air-polluted environment: physiological and anthropometric protocol for a prospective cohort study (Healthy Aging in Industrial Environment Study – Program 4)

et al. 2020

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IntroductionAmbient air pollution is a global environmental problem, which causes adverse health effects and premature deaths worldwide. Although regular exercise and physical activity have evident health benefits, the influence of long-term air pollution exposure during regular outdoor running has not been definitively clarified.Methods and analysisThis study protocol describes the physiological and anthropometric perspectives of the ‘Healthy Aging in Industrial Environment’ Study – Programme 4 (4HAIE). The 4HAIE research project is intended to be a single-centre, prospective, longitudinal and multidisciplinary cohort study. The presented study protocol describes the cross-sectional measurements and analyses. Overall, 1500 adult participants (age 18–65 years), runners and inactive individuals, living in a high or low air-polluted area of the Czech Republic will be recruited. We will measure and analyse biomarkers of oxidative stress and inflammation in the blood, exercise capacity (graded exercise test and spiroergometry), blood pressure, lung function (spirometry), cardiac autonomic regulation and anthropometry (body composition).Ethics and disseminationThe 4HAIE study protocol has already been approved by the Ethics Committee of the University of Ostrava (3/2018). A detailed participant information sheet will be provided to each individual prior to obtaining their written informed consent. The study poses little to no risk to participants. The findings of this study will be disseminated at regional and international conferences, in peer-reviewed journals and via social and broadcast media.

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Long-term exposure to air pollution might increase prevalence of osteoporosis in Chinese rural population

Cited by 44 publications

References 49 publications

Association of Air Pollutants with Incident Chronic Kidney Disease in a Nationally Representative Cohort of Korean Adults

Association of Air Pollutants with Incident Chronic Kidney Disease in a Nationally Representative Cohort of Korean Adults

Particulate Air Pollution and Osteoporosis: A Systematic Review

Regular running in an air-polluted environment: physiological and anthropometric protocol for a prospective cohort study (Healthy Aging in Industrial Environment Study – Program 4)

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