Long-term exposure to air pollution is associated with biological aging

Ward‐Caviness, Cavin; Nwanaji‐Enwerem, Jamaji C.; Wolf, Kathrin; Wahl, Simone; Colicino, Elena; Trevisi, Letizia; Kloog, Itai; Just, Allan C.; Vokonas, Pantel; Cyrys, Josef; Gieger, Christian; Schwartz, Joel; Baccarelli, Andrea A.; Schneider, Alexandra; Peters, Annette

doi:10.18632/oncotarget.12903

Cited by 130 publications

(118 citation statements)

References 79 publications

(105 reference statements)

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…The number of studies examining relationships of ambient PM2.5 with DNAm-age are limited, but our results are consistent with what they report 8, 10, 52 . Here, we observed comparable, significant positive associations of PM2.5, sulfate, and ammonium with DNAm-age.…”

Section: Discussionsupporting

confidence: 92%

Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age

Nwanaji‐Enwerem

Colicino

Dai

et al. 2017

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

The mitochondrial genome has long been implicated in age-related disease, but no studies have examined its role in the relationship of long-term fine particle (PM2.5) exposure and DNA methylation age (DNAm-age) – a novel measure of biological age. In this analysis based on 940 observations between 2000 and 2011 from 552 Normative Aging Study participants, we determined the roles of mitochondrial DNA haplogroup variation and mitochondrial genome abundance in the relationship of PM2.5 with DNAm-age. We used the GEOS-chem transport model to estimate address-specific, one-year PM2.5 levels for each participant. DNAm-age and mitochondrial DNA markers were measured from participant blood samples. Nine haplogroups (H, I, J, K, T, U, V, W, and X) were present in the population. In fully-adjusted linear mixed-effects models, the association of PM2.5 with DNAm-age (in years) was significantly diminished in carriers of haplogroup V (Pinteraction= 0.01; β= 0.18, 95%CI: −0.41, 0.78) compared to non-carriers (β= 1.25, 95%CI: 0.58, 1.93). Mediation analysis estimated that decreases in mitochondrial DNA copy number, a measure of mitochondrial genome abundance, mediated 12% of the association of PM2.5 with DNAm-age. Our data suggests that the mitochondrial genome plays a role in DNAm-age relationships particularly in the context of long-term PM2.5 exposure.

show abstract

Section: Discussionsupporting

confidence: 92%

Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age

Nwanaji‐Enwerem

Colicino

Dai

et al. 2017

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Given previous observations that associations with epigenetic biomarkers may vary based on sex [17,57], we decided to evaluate sex-stratified associations for those PCs significant in the primary analysis. We also stratified analyses based on indicators of greenspace in neighborhoods, as greenspace may be a potentially protective factor for health outcomes [2,32].…”

Section: Analytic Modelsmentioning

confidence: 99%

Epigenetic predictors of all-cause mortality are associated with objective measures of neighborhood disadvantage in an urban population

Ward‐Caviness

Martin

et al. 2020

Clin Epigenet

Self Cite

View full text Add to dashboard Cite

Background: Neighborhood characteristics are robust predictors of overall health and mortality risk for residents. Though there has been some investigation of the role that molecular indicators may play in mediating neighborhood exposures, there has been little effort to incorporate newly developed epigenetic biomarkers into our understanding of neighborhood characteristics and health outcomes. Methods: Using 157 participants of the Detroit Neighborhood Health Study with detailed assessments of neighborhood characteristics and genome-wide DNA methylation profiling via the Illumina 450K methylation array, we assessed the relationship between objective neighborhood characteristics and a validated DNA methylationbased epigenetic mortality risk score (eMRS). Associations were adjusted for age, race, sex, ever smoking, ever alcohol usage, education, years spent in neighborhood, and employment. A secondary model additionally adjusted for personal neighborhood perception. We summarized 19 neighborhood quality indicators assessed for participants into 9 principal components which explained over 90% of the variance in the data and served as metrics of objective neighborhood quality exposures. Results: Of the nine principal components utilized for this study, one was strongly associated with the eMRS (β = 0.15; 95% confidence interval = 0.06-0.24; P = 0.002). This principal component (PC7) was most strongly driven by the presence of abandoned cars, poor streets, and non-art graffiti. Models including both PC7 and individual indicators of neighborhood perception indicated that only PC7 and not neighborhood perception impacted the eMRS. When stratified on neighborhood indicators of greenspace, we observed a potentially protective effect of large mature trees as this feature substantially attenuated the observed association.

show abstract

“…Various types of cellular stress seem to affect epigenetic alterations that may lead to deleterious consequences. Exposure to fine particle air pollution affects DNA methylation status in blood cells [ 178 , 179 , 180 , 181 , 182 , 183 ] and placenta [ 184 ]. Cigarette smoking has adverse effects on health and is associated with changes in epigenetic marks.…”

Section: Epigenetics and Agingmentioning

confidence: 99%

Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism

Soda

2018

IJMS

View full text Add to dashboard Cite

Recent investigations have revealed that changes in DNA methylation status play an important role in aging-associated pathologies and lifespan. The methylation of DNA is regulated by DNA methyltransferases (DNMT1, DNMT3a, and DNMT3b) in the presence of S-adenosylmethionine (SAM), which serves as a methyl group donor. Increased availability of SAM enhances DNMT activity, while its metabolites, S-adenosyl-l-homocysteine (SAH) and decarboxylated S-adenosylmethionine (dcSAM), act to inhibit DNMT activity. SAH, which is converted from SAM by adding a methyl group to cytosine residues in DNA, is an intermediate precursor of homocysteine. dcSAM, converted from SAM by the enzymatic activity of adenosylmethionine decarboxylase, provides an aminopropyl group to synthesize the polyamines spermine and spermidine. Increased homocysteine levels are a significant risk factor for the development of a wide range of conditions, including cardiovascular diseases. However, successful homocysteine-lowering treatment by vitamins (B6, B12, and folate) failed to improve these conditions. Long-term increased polyamine intake elevated blood spermine levels and inhibited aging-associated pathologies in mice and humans. Spermine reversed changes (increased dcSAM, decreased DNMT activity, aberrant DNA methylation, and proinflammatory status) induced by the inhibition of ornithine decarboxylase. The relation between polyamine metabolism, one-carbon metabolism, DNA methylation, and the biological mechanism of spermine-induced lifespan extension is discussed.

show abstract

Long-term exposure to air pollution is associated with biological aging

Cited by 130 publications

References 79 publications

Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age

Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age

Epigenetic predictors of all-cause mortality are associated with objective measures of neighborhood disadvantage in an urban population

Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism

Contact Info

Product

Resources

About