Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus

Kimura, Masaki; Tateishi, Naoto; Shiota, Tomoei; Yoshie, Fumihiko; Yamauchi, Hideki; Suzuki, Masato; Shibasaki, Toshiaki

doi:10.1097/00001756-200403220-00028

Cited by 20 publications

(19 citation statements)

References 21 publications

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“…Increased leptin and insulin action in the brain may thus contribute to the modulation of energy homeostasis in exercised rats. Despite a recent publication showing that the 12-week wheel exercise protocol reduced the expression of ObRb mRNA in the arcuate nucleus (32), our data demonstrate that after a session of exercise, there were no changes in the expression of hypothalamic proteins involved in leptin and insulin signal transduction. However, the phosphorylation status of these proteins was deeply modified.…”

Section: Discussioncontrasting

confidence: 99%

Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats

et al. 2006

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Prolonged exercise of medium to high intensity is known to promote a substantial effect on the energy balance of rats. In male rats, moderately to severely intense programs lead to a reduction in food intake. However, the exact causes for the appetite-suppressive effects of exercise are not known. Here, we show that intracerebroventricular insulin or leptin infusion reduced food intake in exercised rats to a greater extent than that observed in control animals. Exercise was associated with a markedly increased phosphorylation/activity of several proteins involved in leptin and insulin signal transduction in the hypothalamus. The regulatory role of interleukin (IL)-6 in mediating the increase in leptin and insulin sensitivity in hypothalamus was also investigated. Treatment with insulin or leptin markedly reduced food intake in exercised rats that were pretreated with vehicle, although no increase in sensitivity to leptin-and insulin-induced anorexia after pretreatment with anti-IL-6 antibody was detected. The current study provides direct measurements of leptin and insulin signaling in the hypothalamus and documents increased sensitivity to these hormones in the hypothalamus of exercised rats in an IL-6 -dependent manner. These findings provide support for the hypothesis that the appetite-suppressive actions of exercise may be mediated by the hypothalamus.

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Section: Discussioncontrasting

confidence: 99%

Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats

et al. 2006

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“…It was also found that energy intake was significantly increased, but caused no change in body mass in athletes after 8 months of exercise training (Desgorces et al 2004). In addition, other studies have found that wheel exercise training had no effect on energy intake (Kimura et al 2004). In the present study, we showed that long-term forced exercise training increased energy intake in A. chevrieri, which might be associated with the increase of RMR.…”

Section: Rmr and Energy Intakementioning

confidence: 98%

“…Different species show different sensitivity of exercise training-induced body mass regulation. For example, exercise training induced an increased energy intake and a decreased body mass in rats (Levin & Dunn-Meynell 2004); however, male Wistar rats showed an increased or unchanged energy intake with no change in body mass (Kimura et al 2004), while energy intake and body mass † These authors contributed equally to this work. *Correspondence: Z.K.…”

Section: Introductionmentioning

confidence: 99%

Effects of long-term forced exercise training on body mass, energy metabolism and serum leptin levels inApodemus chevrieri(Mammalia: Rodentia: Muridae)

Zhu

Zhang

Lin

et al. 2013

Italian Journal of Zoology

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Mammals, including rodents, are able to maintain a stable body mass, which is a result of balance between energy intake and energy expenditure. Exercise training can increase energy expenditure and is considered one of the most important factors affecting energy balance in mammals. In order to understand the effect of exercise on body mass regulation and energy metabolism, changes of body mass, metabolic rate, energy intake, serum leptin levels and body composition were measured in Apodemus chevrieri during an 8-week forced exercise training with a treadmill. The results showed that exercise training had no significant effects on body mass, but the metabolic rate and energy intake were increased during the 8-week exercise training. Body fat mass and serum leptin levels decreased in the exercise group compared to the control group. There was a positive relationship between serum leptin levels and body fat mass in the control group, but no relationship in the exercise group. Mass of liver and digestive tracts increased significantly, while wet carcass mass and water of carcass decreased significantly in the exercise group compared to the control group. The results indicated that A. chevrieri mobilized body fat mass, and increased the metabolic rate and energy intake to regulate the body mass and energy balance during long-term forced exercise training. Serum leptin levels would be potentially involved in the body mass regulation and thermogenesis during the long-term forced exercise training.

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“…Alguns estudos demonstraram que a diminuição do tecido adiposo em resposta ao exercício está relacionada a alterações no receptor longo, Ob-Rb. Kimura (49) investigou, em ratos, se o exercício espontâneo regulou a expressão da leptina após um período de 12 semanas. Os ratos apresentaram redução na gordura corporal e diminuição na concentração de leptina, além de downregulation no mRNA do receptor.…”

Section: Leptina E Exercício Físicounclassified

Leptina: aspectos sobre o balanço energético, exercício físico e amenorréia do esforço

Ribeiro

Santos

Silva

et al. 2007

Arq Bras Endocrinol Metab

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RESUMOO presente manuscrito teve por objetivo realizar uma revisão bibliográfica acerca do papel da leptina no balanço energético, no exercício físico e na incidência da amenorréia do esforço. A leptina é um hormônio secretado pelo tecido adiposo, reconhecido principalmente por sua ação adipostáti-ca sobre o sistema nervoso central. Esse hormônio sinaliza o hipotálamo a respeito das reservas energéticas, modulando o funcionamento dos eixos hormonais que envolvam o hipotálamo e a hipófise. A leptina tem ainda ações periféricas importantes, incluindo seu papel sobre o tecido ovariano. Os mecanismos de sinalização intracelular desse hormônio foram identificados no hipotálamo, porém em tecidos periféricos há necessidade de maiores investigações. Existe certo consenso de que quando o exercício e a ingestão alimentar são capazes de promover um balanço energético negativo, as concentrações plasmáticas de leptina diminuem, alterando conseqüentemente: a liberação hipotalâmica de GnRH (fator hipotalâmico de liberação de gonadotrofinas); a liberação hipofisária de LH (hormônio luteinizante) e FSH (hormônio folículo-estimulante). Como resultado, há menor liberação de estrógenos ovarianos. Esse processo pode iniciar a chamada amenorréia hipotalâmica funcional, com repercussões na saúde da mulher. Nessa perspectiva, a avaliação do gasto energético e a elaboração de um plano alimentar adequado em atletas são fundamentais. The aim of this manuscript was to review the knowledge about leptin, detailing its relationship with energetic intake and physical activity. Leptin is an adipocyte hormone, recognized mainly for its putative role in control of energy expenditure, food intake, body weight and reproductive function. Leptin has still important peripheral actions, including its role on the ovarian tissue. The intracellular signaling mechanisms are recognized in hypothalamus, but in peripheral tissue are not fully understood. The exercise, when practiced by women, if not appropriately planned according to food intake, can modify the leptin release. When energy imbalances induced by exercise and/or deficient food ingestion occurs, low leptin levels are observed, leading to a reduction in GnRH (gonadotropin-release hormone), in LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in pituitary, and consequently a minor release of ovarian estrogens. This process is named hypothalamic amenorrhea, and has repercussions in the woman's health. In this perspective, it is important to emphasize the need to evaluate the energy expenditure from exercise and to formulate adequate alimentary plans to these individuals.

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Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus

Cited by 20 publications

References 21 publications

Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats

Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats

Effects of long-term forced exercise training on body mass, energy metabolism and serum leptin levels inApodemus chevrieri(Mammalia: Rodentia: Muridae)

Leptina: aspectos sobre o balanço energético, exercício físico e amenorréia do esforço

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