Long-term exercise at different intensities can reduce the inflammatory response in the brains of methamphetamine-treated mice

Li, Yue; Re, Guo-Fen; Zhao, Yu; Wu, Xiaocong; Zhou, Rui-Yi; Kuang, Yi‐Qun; Wang, Kunhua

doi:10.1016/j.bbrc.2022.05.042

Cited by 3 publications

(1 citation statement)

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“…For example, when astrocytes are activated, they release various inflammatory factors, including tumor necrosis factor, causing an increase in the release of inflammatory factors in brain regions, such as hippocampus and striatum, further aggravating the neurotoxicity of MA and promoting damage to the blood–brain barrier [ 24 , 25 ]. By contrast, prolonged moderate-to-intense aerobic exercise induces adaptive mechanisms in the immune system, leading to a decrease in the concentration of interleukin-6 and tumor necrosis factor α in the body while making the concentration of anti-inflammatory factors, such as interleukin-10, increase, thus attenuating the damage of MA on the blood–brain barrier and nerves [ 26 , 27 ]. MA intake could also lead to oxidative stress in endothelial cells, thereby decreasing the level of tight junction proteins and eventually leading to blood–brain barrier dysfunction, and the antioxidant effect of exercise is well known [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Aerobic Exercise on Markers of Brain Injury in Methamphetamine-Dependent Individuals: A Randomized Controlled Trial

Zhu

Jin

et al. 2022

Brain Sciences

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Objective: Drug dependence has become a major global public health problem. This study aimed to investigate the effects of moderate-intensity aerobic exercise on the blood–brain barrier and neurological damage in methamphetamine (MA)-dependent individuals. Methods: MA-dependent individuals (all males) were recruited and randomly divided into MA exercise group (MAE) and MA control group (MAC) by using random number table method. The MAE group underwent 12 weeks of moderate-intensity aerobic exercise, and the MAC group underwent conventional detoxification. The Neurofilament light chain (NfL), S100 calcium binding protein b (S100b), and Neuron-Specific Enolase (NSE) levels in the blood of MA-dependent individuals were measured before and after the exercise intervention. Results: After the exercise intervention was implemented, the amount of change in NfL in the plasma of the MAE (1.75 ± 1.40) group was significantly different from that of the MAC (0.60 ± 1.21) group (p < 0.01); the amount of change in NSE in the serum of the MAE [−1.51 (−3.99~0.31)] group was significantly different from that of the MAC [0.03 (−1.18~1.16)] group (p < 0.05); and the amount of change in S100b in the serum of the MAE [0.66 (0.40~0.95)] group was not significantly different from that of the MAC (0.60 (0.21~1.04)) group (p > 0.05). Conclusion: This study showed that 12 weeks of moderate-intensity aerobic exercise treatment significantly promoted the recovery of blood–brain barrier and neurological damage in MA-dependent patients compared with conventional withdrawal.

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