Long‐term evolution of superficial optic disc drusen

Malmqvist, Lasse; Lund‐Andersen, Henrik; Hamann, Steffen

doi:10.1111/aos.13315

Cited by 35 publications

(36 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the investigators noted that as retinal sensitivity decreases with age, a decrement of 12% would have been expected in their patient population, even in the absence of ODD (Malmqvist et al 2016b). However, the investigators noted that as retinal sensitivity decreases with age, a decrement of 12% would have been expected in their patient population, even in the absence of ODD (Malmqvist et al 2016b).…”

Section: Perimetrymentioning

confidence: 93%

“…Optic discs harbouring ODD tend to change in appearance with time, such that drusen assume a more superficial location prior to adulthood (Malmqvist et al 2016b). In a recent report, Malmqvist and colleagues explored the hypothesis that fundus appearance alterations secondary to ODD are an unevenly distributed, as opposed to a uniformly continuous process, over time.…”

Section: Fundus Examinationmentioning

confidence: 99%

“…In a recent report, Malmqvist and colleagues explored the hypothesis that fundus appearance alterations secondary to ODD are an unevenly distributed, as opposed to a uniformly continuous process, over time. Six of eight patients had what were described as 'severe structural changes' of the optic nerve head, and in most cases, anatomical optic disc changes secondary to ODD were established at the first clinical visit these patients had as teenagers (Malmqvist et al 2016b). Six of eight patients had what were described as 'severe structural changes' of the optic nerve head, and in most cases, anatomical optic disc changes secondary to ODD were established at the first clinical visit these patients had as teenagers (Malmqvist et al 2016b).…”

Section: Fundus Examinationmentioning

confidence: 99%

“…The type of visual field defects has also been found to depend on visibility by slit-lamp ophthalmoscopy. A slow progression of visual field defects in ODD patients has been described (Chambers & Walsh 1951;Lansche & Rucker 1957;Hoover et al 1988;Spencer et al 2004;Lee & Zimmerman 2005;Malmqvist et al 2016b) and has been found to correspond to the progression from buried to superficial ODD, during the so-called transition phase (Frisen 2008 A slow progression of visual field defects in ODD patients has been described (Chambers & Walsh 1951;Lansche & Rucker 1957;Hoover et al 1988;Spencer et al 2004;Lee & Zimmerman 2005;Malmqvist et al 2016b) and has been found to correspond to the progression from buried to superficial ODD, during the so-called transition phase (Frisen 2008 …”

Section: Automated Perimetrymentioning

confidence: 99%

“…These defects are more commonly observed in eyes with visible ODD (Savino et al 1979;Mustonen 1983;Mistlberger et al 2001;Wilkins & Pomeranz 2004;Malmqvist et al 2016c). Studies suggest that the evolution of ODD involves a transition phase in adolescence, during which visual field defects may rapidly progress with minimal worsening thereafter (Frisen 2008;Malmqvist et al 2016b). Optic disc drusen (ODD)related afferent visual injury likely involves mechanical stress on structures within the prelaminar scleral canal leading to retrograde axonal degradation and ganglion cell death, but the exact mechanisms that govern vision loss in this condition remain unknown.…”

Section: Overviewmentioning

confidence: 99%

See 4 more Smart Citations

Optic disc drusen: understanding an old problem from a new perspective

Hamann

Malmqvist

Costello

2018

Acta Ophthalmologica

Self Cite

101

106

View full text Add to dashboard Cite

Optic disc drusen (ODD) are acellular deposits located in the optic nerve head of up to 2.4% of the population. They may develop as by-products of impaired axonal metabolism in genetically predisposed individuals, in whom a narrow scleral canal is hypothesized to play a role. Although ODD are often considered as benign innocent bystanders, recognized as part of a routine ophthalmological examination, the vast majority of patients with ODD have visual field defects. Optic disc drusen (ODD)-associated complications with severe visual loss, most often due to anterior ischaemic optic neuropathy, are also known to occur. There are no treatments available to prevent or ameliorate the vision loss caused by ODD. In children, the ODD are usually uncalcified and buried within the optic nerve head tissue. In these cases, the condition can be difficult to diagnose, as it often resembles a papilloedema with optic nerve head swelling caused by raised intracranial pressure. During the teenage years, the ODD progressively become more calcified and probably also larger, which allow them to be visible on ophthalmoscopy. With the advent and proper utilization of high-resolution modalities of optical coherence tomography (OCT), it has now become possible to detect even the smallest and most deeply located ODD. This allows for ODD detection at a much earlier developmental stage than has previously been possible and enhances the possibilities of research in underlying mechanisms. A review of the literature on ODD was conducted using the PUBMED database. The review focuses on the current knowledge regarding pathogenesis, diagnostics, clinical disease-tracking methodologies, structure-function relationships and treatment strategies of ODD.

show abstract

Section: Perimetrymentioning

confidence: 93%

Section: Fundus Examinationmentioning

confidence: 99%

Section: Fundus Examinationmentioning

confidence: 99%

Section: Automated Perimetrymentioning

confidence: 99%

Section: Overviewmentioning

confidence: 99%

See 3 more Smart Citations

Optic disc drusen: understanding an old problem from a new perspective

Hamann

Malmqvist

Costello

2018

Acta Ophthalmologica

Self Cite

101

106

View full text Add to dashboard Cite

show abstract

Optic disc drusen: a systematic review

et al. 2020

View full text Add to dashboard Cite

Multimodal Imaging Features of Optic Disc Drusen

Yan

Ludwig

Liao

2021

American Journal of Ophthalmology

View full text Add to dashboard Cite

To identify key en face multimodal imaging features of optic disc drusen (ODD).DESIGN: Retrospective cross-sectional study. METHODS: SETTING: a single academic center. PATIENT OR STUDY POPULATION: 786 patients (10-82 years of age) with diagnostic codes for optic disc drusen (ODD) in clinical notes extracted using natural language processing. INTERVENTION OR OBSERVATION PROCEDURES: color fundus imaging, green-light and blue-light fundus autofluorescence (FAF), near-infrared reflectance (NIR), and enhanced-depth imaging optical coherence tomography (EDI-OCT). MAIN OUTCOME MEASUREMENTS: Ophthalmic imaging characteristics and sensitivity of en face imaging compared with EDI-OCT.RESULTS: A total of 38 patients (61 eyes) had highquality EDI-OCT scans and en face multimodal imaging. Green-light FAF imaging had the highest diagnostic sensitivity (96.8%) for ODD and showed homogeneous hyperautofluorescence, whereas blue-light FAF imaging had heterogeneous brightness, which helped differentiate superficial from deep ODD. Blue-light FAF (93.5%) and NIR (91.8%) imaging were also sensitive tests and revealed papillary and peripapillary features that were not well seen on green-light FAF, including the size and depth of ODD, morphology of the optic disc, and common ODD-associated structures such as horizontal hyperreflective lines and peripapillary hyper-reflective ovoid mass-like structures (PHOMS). Color fundus imaging had the lowest sensitivity (82%). There was good interrater reliability for all en face imaging modalities (P < .0001 for all).CONCLUSIONS: In en face imaging, green-light FAF had the highest sensitivity for the diagnosis of ODD, whereas blue-light FAF and NIR images provided more information regarding the severity, location, depth, and size of ODD. In eyes that are negative on green-light FAF, EDI-OCT should be performed and provides the highest-resolution characterization of the entire optic disc to assess or rule out ODD.

show abstract

Long‐term evolution of superficial optic disc drusen

Abstract: Minimal or no change in superficial optic disc anatomy and visual fields in ODD patients oldest at the initial examination suggests that anatomical progression of ODD in patients with hereditary ODD happens primarily before adulthood.

Cited by 35 publications

References 18 publications

Optic disc drusen: understanding an old problem from a new perspective

Optic disc drusen: understanding an old problem from a new perspective

Optic disc drusen: a systematic review

Multimodal Imaging Features of Optic Disc Drusen

Contact Info

Product

Resources

About