Long-term evolution of squamous-cell cancer in Plummer-Vinson syndrome

Aday, Ulaş; Gündeş, Ebubekir; Çetin, Durmuş Ali; Çiyiltepe, Hüseyin; Başak, Kayhan; Duman, Mustafa

doi:10.5114/pg.2017.70477

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Speculations include mucosal atrophy, altered repair mechanism, and the changes seen in the cellular kinetics. 26 In our study, four patients had concomitant squamous cell carcinoma of the esophagus along with esophageal web. All these four patients had long history of dysphagia (range 72-100 months) without alarming symptoms and presented with recent worsening of dysphagia and weight loss.…”

Section: Discussionmentioning

confidence: 62%

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Plummer–Vinson syndrome: A decade's experience of 132 cases from a single center

Patil

Malipatel

Devarbhavi

2020

J of Gastro and Hepatol

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Background and AimPlummer–Vinson syndrome (PVS) comprises triad of iron deficiency anemia, dysphagia, and post‐cricoid esophageal web. PVS is rare nowadays due to improved nutritional status. However, we encountered patients with PVS regularly at our center. Data regarding PVS are limited; hence, we aimed to study the clinical features, treatment outcomes, and development of complications in patients with PVS.MethodsThe study was conducted over a 10‐year period (January 2008 to January 2018) in a medical college setting. All adults with dysphagia, anemia, and post‐cricoid web or those with iron deficiency anemia and post‐cricoids web were included in the study. Patients were treated with iron supplementation and Savary–Gilliard bougie dilation of the web. Patients were followed‐up for the recurrence of dysphagia and development of complications.ResultsOverall, 153 patients exhibited esophageal web, of which 132 (86.27%) patients had concomitant PVS and 21 (13.7%) patients did not. The mean age was 43.50 years (range 16–76) and 113 (85.6%) were women. Single session of Savary–Gilliard bougie dilation was successful in 90.7% of patients in relieving dysphagia and 9.3% developed recurrence, requiring repeated dilations. Four patients had concomitant squamous cell carcinoma of esophagus along with PVS and two developed upper gastrointestinal malignancy during follow‐up.ConclusionPlummer–Vinson syndrome is predominantly seen in middle aged women and present with symptoms of iron deficiency anemia and early grade dysphagia. Single session of Savary–Gilliard bougie dilation was successful in majority of patients in relieving dysphagia. Overall risk of developing upper gastrointestinal malignancy was 4.5%.

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Section: Discussionmentioning

confidence: 62%

“…The increased risk of malignancy in PVS is exactly not known. Speculations include mucosal atrophy, altered repair mechanism, and the changes seen in the cellular kinetics 26 . In our study, four patients had concomitant squamous cell carcinoma of the esophagus along with esophageal web.…”

Section: Discussionmentioning

confidence: 72%

Plummer–Vinson syndrome: A decade's experience of 132 cases from a single center

Patil

Malipatel

Devarbhavi

2020

J of Gastro and Hepatol

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“… 30 Plummer–Vinson (or Paterson–Kelly) syndrome has been associated with carcinoma of the upper third of the esophagus and is related to both iron-deficiency anemia and vitamin B deficiencies. 31 Human papillomavirus (HPV) and Epstein–Barr virus have also been associated with ESCC. 32 …”

Section: Risk Factors For Esccmentioning

confidence: 99%

Achalasia and esophageal cancer: risks and links

Torres-Aguilera¹,

Troche²

2018

CEG

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Esophageal cancer affects more than 4,50,000 persons worldwide, and its incidence has increased in recent years. It is the eighth most common cancer across the globe. The main histologic types are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA), and their associated risk factors are well known. Achalasia, an idiopathic esophageal disorder that conditions aperistalsis and the absence of lower esophageal sphincter relaxation, stands out among them. The prevalence of ESCC in subjects with esophageal achalasia is 26 in every 1,000 cases, whereas the prevalence of EA is 4 in every 1,000. Patients with achalasia have a 50 times higher risk of presenting with ESCC than the general population, and the disease manifests 20–25 years after achalasia symptom onset. Multiple mechanisms are related to the development of ESCC in achalasia, and they include bacterial overgrowth, food stasis, genetic alterations, and chronic inflammation. Regarding the risk of EA in achalasia patients, most cases are associated with Barrett’s esophagus, due to uncontrolled chronic acid reflux. Given that achalasia is a well-established factor for ESCC/EA, clinicians must be aware of said associations to enable the development of programs for the prevention and opportune detection of these cancers in patients with achalasia.

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