Long‐term evaluation of erythema and pigmentation induced by ultraviolet radiations of different wavelengths

Suh, Kee Suck; Roh, Hyo Jin; Choi, Soo Young; Jeon, Young Seung; Doh, Ki-Seung; Bae, J.-H.; Kim, S.‐T.

doi:10.1111/j.1600-0846.2007.00213.x

Cited by 40 publications

(28 citation statements)

References 23 publications

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“…The acute side effects of NBUVB include erythema, edema, blistering, pruritus, and reactivation of herpes simplex virus, but these usually resolve within several days30. Although previous studies have described a possibility of photoaging and carcinogenesis in association with NBUVB, there is still no evidence that this occurs.…”

Section: Discussionmentioning

confidence: 99%

Narrowband Ultraviolet B Phototherapy of Early Stage Mycosis Fungoides in Korean Patients

et al. 2011

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BackgroundNarrowband UVB (NBUVB) is currently used to treat early mycosis fungoides (MF). There are a number of reports on the efficacy and safety of NBUVB in Caucasians, but little data is available for Asians.ObjectiveThis study was designed to evaluate the effectiveness and safety of NBUVB for early stage MF in Korean patients.MethodsWe enrolled 14 patients (12 men, 2 women; age range, 10~64 years) with clinically and histologically proven MF. Three patients were stage IA, and the others were stage IB. The patients received NBUVB phototherapy three times a week. The starting dose was 70% of the minimal erythema dose and was increased in 20 percent increments if the previous treatment did not cause erythema. Clinical response, total number of treatments, total cumulative dose, duration of remission and side effects were investigated.ResultsEleven of 14 patients (78.6%) achieved complete remission within a mean of 15.36±5.71 weeks (range, 5~27 weeks), 31.0±7.4 treatments (range, 16~39 treatments) and a mean cumulative UVB dose of 31.31±12.16 J/cm2 (range, 11.4~46.8 J/cm2). Three of the 14 patients (21.4%) achieved a partial remission. After discontinuation of treatment, 6 of 11 patients (54.5%) with complete remission relapsed after a mean of 8.5±4.09 months. No serious adverse effects were observed except for hyperpigmentation (7/14, 50%).ConclusionOur data suggest that NBUVB therapy is safe and effective for the treatment of early stage MF in Korean patients.

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Section: Discussionmentioning

confidence: 99%

Narrowband Ultraviolet B Phototherapy of Early Stage Mycosis Fungoides in Korean Patients

et al. 2011

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“…IPD occurs during the first minutes of exposure to UVA, and then fades within few hours 6 , 8 . PPD appears within hours of higher doses of UVA exposure and persist up to several days or weeks 7 , 9 . DT develops over 3–7 days after UVB exposure, and then remains for weeks 10 .…”

Section: Cosmetic Tanningmentioning

confidence: 99%

“…Sunbeds have several times higher UVA fluence rates than found in solar radiation under relevant conditions, 19 , 20 and, due to this, IPD and PPD are pronounced after sunbathing. Additionally, under certain conditions UVA-induced pigmentation lasts longer than UVB-induced DP 9 . This can be partly explained by the facts that UVB-induced tanning is located in the upper layers of the epidermis, while UVA-induced tanning is primary localized in the basal cell layer 11 .…”

Section: Cosmetic Tanningmentioning

confidence: 99%

Beneficial effects of UV radiation other than via vitamin D production

Juzeniene

Moan

2012

Dermato-Endocrinology

171

126

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Most of the positive effects of solar radiation are mediated via ultraviolet-B (UVB) induced production of vitamin D in skin. However, several other pathways may exist for the action of ultraviolet (UV) radiation on humans as focused on in this review. One is induction of cosmetic tanning (immediate pigment darkening, persistent pigment darkening and delayed tanning). UVB-induced, delayed tanning (increases melanin in skin after several days), acts as a sunscreen. Several human skin diseases, like psoriasis, vitiligo, atopic dermatitis and localized scleroderma, can be treated with solar radiation (heliotherapy) or artificial UV radiation (phototherapy). UV exposure can suppress the clinical symptoms of multiple sclerosis independently of vitamin D synthesis. Furthermore, UV generates nitric oxide (NO), which may reduce blood pressure and generally improve cardiovascular health. UVA-induced NO may also have antimicrobial effects and furthermore, act as a neurotransmitter. Finally, UV exposure may improve mood through the release of endorphins.

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“…In particular, sulforaphane, which is converted from a major glucosinolate in broccoli/broccoli sprouts (Zhang et al 1992;Clarke et al 2008), has been demonstrated to be not only effective in preventing chemically induced cancers in animal models (Fahey et al 1997;Fahey et al 2002;Zhang et al 1994;, but also in inhibiting the growth of established tumors (Singh et al 2004b;Jackson and Singletary 2004). The down-regulation of NF-κB function by sulforaphane treatment has been reported in prostate and colon cancer cells as well (Choi et al 2007;Xu et al 2005;Jeong et al 2004;Khor et al 2006). Based on this study, they concluded that combination of sulforaphane with TRAIL would be a promising strategy for targeting pancreatic TICs (Kallifatidis et al 2009).…”

Section: Sulforaphanementioning

confidence: 95%

Nutraceuticals and Cancer

Sarkar¹

2012

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Long‐term evaluation of erythema and pigmentation induced by ultraviolet radiations of different wavelengths

Cited by 40 publications

References 23 publications

Narrowband Ultraviolet B Phototherapy of Early Stage Mycosis Fungoides in Korean Patients

Narrowband Ultraviolet B Phototherapy of Early Stage Mycosis Fungoides in Korean Patients

Beneficial effects of UV radiation other than via vitamin D production

Nutraceuticals and Cancer

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