Long-term endothelial changes in phakic eyes after Artisan intraocular lens implantation to correct myopia

Abstract

Continuous endothelial cell loss was observed after surgery during a 5-year follow-up, especially during the first 2 years. A decrease in the coefficient of variation and an increase in the percentage of hexagonal cells were observed over time, reflecting the increasing stability and remodeling of the corneal endothelial cells 5 years postoperatively.

Secondary Artisan–Verysise intraocular lens implantation for aphakic correction in post-traumatic vitrectomized eye

“…Several studies of Artisan iris-fixated IOL implantation have reported endothelial damage and cell loss. 6,7 Consistent with previous reports on phakic and aphakic eyes, [6][7][8] Artisan IOLs in our study induced a mean corneal endothelial cell loss of 8.1% in first 6 months of follow-up. Some limitations of our study were short follow-up for ECD measurements, and lack of data about other important parameters like coefficient of variation and percentage of hexagonal cells.…”

“…Endothelial cell loss of 10.3% in aphakic eyes with sutured fixated PCIOL implantation was reported. 21 Cell loss occurred predominantly during the first year 7 ; however, continuous endothelial cell loss was observed previously after Artisan implantation 7,8 as well as PCIOL. 22 Although the distance between IOL and endothelium is more adequate in aphakic cases, there is likely more movement or IOL donesis than phakic eyes.…”

“…They are easy to place and are associated with a good visual outcome and a low incidence of intraoperative and postoperative complications. 6 Many reported cases of Artisan IOL implantation have had good clinical outcomes 1,[7][8][9][10][11] ; however, despite more than 10 years of favourable clinical experience with this IOL, experience in the literature with implantation of this lens in aphakic and vitrectomized eyes secondary to trauma is scarce. Insertion of Artisan IOL in an eye without vitreous poses challenges, especially when a large incision is required.…”

Artisan iris-fixated toric phakic intraocular lens for the correction of high astigmatism after deep anterior lamellar keratoplasty

“…1 Artisan phakic IOLs have been demonstrated to be a safe option with respect to endothelial cell count, with a reported loss between 8.6% and 14.5% at 5 years. [8][9][10] In our case, the preoperative deep anterior chamber (3.96 mm) and the resultant postoperative critical distances (the distances between the optic edges of the phakic IOL and the corneal endothelium) of 1.71 mm and 2.11 mm (Figure 1) provided a safeguard against endothelial cell loss. 11 The preoperative and 1 year postoperative endothelial cell counts were 2043 cells/mm 2 and 1827 cells/mm 2 , respectively (10.6% cell loss).…”

5-Year Prospective Follow-Up of Artisan Phakic Intraocular Lenses for the Correction of Myopia, Hyperopia and Astigmatism

“…No loss of BCVA occurred but reported complications included iris atrophy in 11.8% and night glare in 6.4%. In a 5-year follow-up study of 49 highly myopic eyes of 30 patients, Benedetti et al [15] reported progressive endothelial cell loss ranging from 2.3% 4 months postoperatively to 9% at 5 years. An increase in hexagonal cells and reduction in coefficient of variation over time was found, reflecting increasing stability and remodelling of the corneal endothelial cells.…”