Long-term elution of monomers from resin-based dental composites

Putzeys, Eveline; Nys, Siemon De; Čokić, Stevan M.; Duca, Radu Corneliu; Vanoirbeek, Jeroen; Godderis, Lode; Meerbeek, Bart Van; Landuyt, Kirsten Van

doi:10.1016/j.dental.2019.01.005

Cited by 72 publications

(93 citation statements)

References 31 publications

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“…CT differs from other CRs with its new generation monomer content. Its monomer elution has been evaluated in a limited number of studies demonstrating a continuous release after an incubation period of a few weeks [3,51,52]. In our study, CT was detected as the most toxic material among three for hGF cell line at 24 h and 1-week time periods.…”

Section: Discussionmentioning

confidence: 71%

“…Cell-based studies evaluating the effects CRs on surrounding tissues were focused on the cytotoxic effects of monomers released after polymerization [3,24,44]. In in vitro cytotoxicity tests for composites, the ratio between sample surface area and culture medium volume was reported to have an impact on the outcome [37].…”

Section: Discussionmentioning

confidence: 99%

“…The impacts of this monomer on the human cell behavior such as viability, growth, and immune responsivity are not yet fully understood. Further studies having longer evaluation periods are needed to investigate the in vitro effects of this monomer on human cell lines because long-term elution and ensuing chronic exposure to monomers from resin based dental materials should not be ignored considering the human health risks [3].…”

Section: Discussionmentioning

confidence: 99%

“…This result may be related to the short-term resistance of hPDLF cells to the possible cytotoxic effect of materials [22]. It has been suggested that cytotoxicity increases as the duration of exposure increases in relation to the cumulative effect caused by continuous monomer release from the materials [3]. Schulz et al [49] examined the effects of different CRs on gene expression of hGF and human gingival keratinocyte cells in 24 h and one week intervals and indicated that cytotoxic effect on hGF cells increased in a one-week period.…”

Section: Discussionmentioning

confidence: 99%

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Cytotoxicity of Different Nano Composite Resins on Human Gingival and Periodontal Ligament Fibroblast Cell Lines: An In Vitro Study

et al. 2020

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The aim of this study is to determine the cytotoxicity of three different nano composite resins (CRs) on human gingival fibroblast (hGF) and periodontal ligament fibroblast (hPDLF) cell lines. These CRs selected were nanohybrid organic monomer-based Admira Fusion (AF), nanohybrid Bis-(acryloyloxymethyl) tricyclo [5.2.1.0.sup.2,6] decane-based Charisma Topaz (CT), and supra nano filled resin-based Estelite Quick Sigma (EQS). MTT assay was performed to assess the cytotoxicity of CRs at 24 h and one week. AF and EQS applied on hGF cells at 24 h and one week demonstrated similar cytotoxic outcomes. Cytotoxicity of CT on hGF cells at one week was higher than 24 h (p = 0.04). Cytotoxicity of CT on hGF cells was higher at 24 h (p = 0.002) and one week (p = 0.009) compared to control. All composites showed higher cytotoxicity on hPDLF cells at one week than the 24 h (AF; p = 0.02, CT; p = 0.02, EQS; p = 0.04). AF and EQS demonstrated lower cytotoxicity on hPDLF cells than the control group at 24 h (AF; p = 0.01, EQS; p = 0.001). CT was found more cytotoxic on hPDLF cells than the control (p = 0.01) and EQS group (p = 0.008) at one week. The cytotoxicity of CRs on hGF and hPDLF cells vary, according to the type of composites, cell types, and exposure time.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cytotoxicity of Different Nano Composite Resins on Human Gingival and Periodontal Ligament Fibroblast Cell Lines: An In Vitro Study

et al. 2020

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“…Some of them study the elution of monomers (mostly BPA, Bis-GMA, TEGDMA, and UDMA) from dental materials after their immersion in methanol or, most frequently, ethanol or deionized water, for a short or an extended period [11,[26][27][28][29][30]. Others study the elution from dental resins immersed in artificial saliva [31][32][33]. Only a few high-performance liquid chromatography (HPLC) methods have been developed for the determination of BPA in blood serum or urine [5,34].…”

Section: Introductionmentioning

confidence: 99%

Validation of a Simple HPLC–UV Method for the Determination of Monomers Released from Dental Resin Composites in Artificial Saliva

Diamantopoulou

Plastiras

Mourouzis

et al. 2020

MPs

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Bisphenol-A (BPA), bisphenol A glycerolate dimethacrylate (Bis-GMA), triethylene glycol dimethacrylate (TEGDMA), and urethane dimethacrylate (UDMA) are organic monomers that can be released from dental composites into the oral cavity. Over specific concentrations, they can act as endocrine disruptors or cause toxic effects. The purpose of this work is to develop and validate an analytical method to determine BPA, Bis-GMA, TEGDMA, and UDMA monomers released from synthetic dental resins in artificial saliva. The method was validated before its application to new hybrid ceramic materials used in computer-aided design and computer-aided manufacturing (CAD/CAM) restorations to determine the release of monomers in various time intervals (e.g., 24 h, and 7, 14, 30, and 60 days), both in methanolic solutions, as well as in artificial saliva. Chromatographic analysis was performed isocratically on a Perfect Sil Target ODS-3 analytical column (250 mm × 4.6 mm, 5 µm) with CH3CN/H2O, 58/42% v/v as mobile phase within 23 min. The developed method was validated in terms of selectivity, linearity, accuracy, and precision.

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Highly Customizable Bone Fracture Fixation through the Marriage of Composites and Screws

Hutchinson

Granskog

Kieseritzky

et al. 2021

Adv Funct Materials

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Open reduction internal fixation (ORIF) metal plates provide exceptional support for unstable bone fractures; however, they often result in debilitating soft-tissue adhesions and their rigid shape cannot be easily customized by surgeons. In this work, a surgically feasible ORIF methodology, called AdhFix, is developed by combining screws with polymer/hydroxyapatite composites, which are applied and shaped in situ before being rapidly cured on demand via high-energy visible-light-induced thiol-ene coupling chemistry. The method is developed on porcine metacarpals with transverse and multifragmented fractures, resulting in strong and stable fixations with a bending rigidity of 0.28 (0.03) N m 2 and a maximum load before break of 220 (15) N. Evaluations on human cadaver hands with proximal phalanx fractures show that AdhFix withstands the forces from finger flexing exercises, while short-and long-term in vivo rat femur fracture models show that AdhFix successfully supports bone healing without degradation, adverse effects, or soft-tissue adhesions. This procedure represents a radical new approach to fracture fixation, which grants surgeons unparalleled customizability and does not result in soft-tissue adhesions.

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Long-term elution of monomers from resin-based dental composites

Cited by 72 publications

References 31 publications

Cytotoxicity of Different Nano Composite Resins on Human Gingival and Periodontal Ligament Fibroblast Cell Lines: An In Vitro Study

Cytotoxicity of Different Nano Composite Resins on Human Gingival and Periodontal Ligament Fibroblast Cell Lines: An In Vitro Study

Validation of a Simple HPLC–UV Method for the Determination of Monomers Released from Dental Resin Composites in Artificial Saliva

Highly Customizable Bone Fracture Fixation through the Marriage of Composites and Screws

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