Long-term Efficacy of Intravenous Immunoglobulin Therapy for Moderate to Severe Atopic Dermatitis in Childhood

Oh, Jae‐Won; Kim, J.; Baik, Hong Kyu; Lee, H.

doi:10.1016/j.jaci.2010.12.154

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“…IVIG (2 g/kg/dose) administered monthly for three doses can be safely and effectively given for the treatment of severe intractable AD. This is worth trials in pediatric patients [51, 52]. …”

Section: Treatmentsmentioning

confidence: 99%

Overview of atopic dermatitis

Kim

2013

Asia Pacific Allergy

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Atopic dermatitis (AD) is a very common chronic disease that reportedly affects 10%-20% of the general population. The prevalence of AD appears to be steadily increasing, at least in developing countries. Two pathogenetic mechanisms have been mentioned. Traditionally immunological aberrations are thought to be a primary event in the initial development of AD ("inside-to-outside hypothesis"). Another hypothesis assumes that there is an intrinsic defect in epidermal barrier. Due to this barrier defect, allergens or irritants can easily penetrate the epidermal barrier, and induce immunologic reaction secondarily ("outside-to-inside hypothesis"). These days the epidermal barrier defect seems to gain more support as a primary event than immunological aberrations in the early changes of AD since the filaggrin mutation was reported in AD patients. Clinically AD initially affects face, and with age, flexural areas are typically involved. AD has many different clinical features. Diagnostic criteria for AD in each country may be a little different, although based on the criteria proposed by Hanifin and Rajka. AD can be controlled effectively with topical and/or systemic treatments and fortunately spontaneously disappears with age. However, in some cases very resistant to conventional therapies, additional treatments such as immunosuppressive agents are needed.

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Section: Treatmentsmentioning

confidence: 99%

Overview of atopic dermatitis

Kim

2013

Asia Pacific Allergy

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Long-term Efficacy of Intravenous Immunoglobulin Therapy for Moderate to Severe Atopic Dermatitis in Childhood

Cited by 1 publication

References 0 publications

Overview of atopic dermatitis

Overview of atopic dermatitis

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