Long‐term efficacy and safety of tacrolimus ointment in the treatment of vitiligo

Du, Juan; Wang, Xiao Yan; Ding, Xiao; Xu, Qian; Zhou, C.; Chang, Jian; Zhang, Jianzhong

doi:10.1111/1346-8138.12283

Cited by 6 publications

(7 citation statements)

References 3 publications

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“…Further, individuals with Fitzpatrick type 3–4 skin had shorter interval to greater than 75% improvement of lesions on the body, head, and neck. Recently, a study found that tacrolimus has better clinical efficacy during the active stages of vitiligo .…”

Section: Topical Therapymentioning

confidence: 99%

Vitiligo nonsurgical treatment: a review of latest treatment researches

et al. 2014

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Vitiligo is a common depigmenting acquired disorder affecting about 1-2% of the world population, regardless of race, ethnic background, or gender. It is characterized by the appearance of milky white maculae because of a loss of melanocytes. The disfiguring nature of vitiligo causes high psychosocial morbidity. This is especially pronounced in populations with darker skin tone, likely because of the marked contrast. A variety of nonsurgical treatment regimens are currently employed in vitiligo. We reviewed the latest studies carried out on different nonsurgical treatment modalities used in vitiligo. All nonsurgical treatment aid to repigment or depigmentation the skin, however, many of them require a prolonged treatment course and may yield minimal results as well as carry unwanted side effects. There is a need for further research into the causes of vitiligo and into discovering better treatments.

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Section: Topical Therapymentioning

confidence: 99%

Vitiligo nonsurgical treatment: a review of latest treatment researches

et al. 2014

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“…The safety and efficacy of topical calcineurin inhibitors in patients with vitiligo has been evaluated in recent years [50][51][52][53][54][55][56][57][58][59][60][61]. Two left-right comparative studies showed that tacrolimus had similar effects to clobetasol propionate 0.05% in the treatment of pediatric patients [51,52].…”

Section: Topical Calcineurin Inhibitorsmentioning

confidence: 99%

“…Lesions on face and anogenital area had better response than other areas [56]. After the clinical trial, 61.7% of patients continued to use tacrolimus ointment, indicating that they were satisfied with the effects of tacrolimus and had a strong desire to continue the treatment [57]. Some studies showed that tacrolimus combined with narrowband UVB or 308-nm excimer laser therapy was superior to phototherapy alone or tacrolimus monotherapy [60,61].…”

Section: Topical Calcineurin Inhibitorsmentioning

confidence: 99%

The Epidemiology and Treatment of Vitiligo: A Chinese Perspective

Du¹

2014

Pigmentary Disorders

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“…The current standard conventional off‐label treatment modalities of vitiligo include topical and oral corticosteroids, topical calcineurin inhibitors, systemic immunosuppressive drugs, oral antioxidants, phototherapy, and surgery, which all vary in efficacy but all require long durations of treatment 7‐12 . Phototherapy has been proven effective in the treatment of vitiligo.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy between localized 308‐nm excimer light and targeted 311‐nm narrowband ultraviolet B phototherapy in vitiligo: A randomized, single‐blind comparison study

Poolsuwan

Churee

Pattamadilok

2020

Photoderm Photoimm Photomed

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Background There are limited data to compare efficacy between recent 308‐nm excimer and conventional 311‐nm narrowband ultraviolet B (NB‐UVB) light in the treatment of vitiligo. Objective To compare efficacy between 308‐nm excimer light and 311‐nm NB‐UVB in patients with symmetrical vitiligo lesions. Methods Thirty‐six symmetrically paired vitiligo lesions on the same anatomical area were enrolled. One side of the symmetrical lesions was treated with localized 308‐nm excimer light, and the opposite side was treated with targeted 311‐nm NB‐UVB assigned randomly by computer. All lesions were treated with the same protocol, for 48 sessions. Repigmentation was evaluated using Vitiligo Area Scoring Index (VASI) and grading the repigmentation was carried out with three independent investigators. Results Thirty‐six symmetrically vitiligo lesions were randomly treated, one side with 308‐nm excimer light and the opposite side with 311‐nm NB‐UVB. After 48 sessions, a significantly lower VASI score and a higher grade of repigmentation were observed in 308‐nm excimer light–treated side (P < .001). Nine lesions (25%) treated with 308‐nm excimer light and only five lesions (13.89%) treated with 311‐nm NB‐UVB achieved excellent repigmentation. The 308‐nm excimer light and 311‐nm NB‐UVB–treated sides rapidly obtained 25% repigmentation within a mean of 19.42 sessions and 26.25 sessions, respectively (P = .002). There was no significant difference in mean cumulative UV dosage (P = .065). Side effect as phototoxicity was similar in both sides (P = .08). Conclusion Localized 308‐nm excimer light appears to be more effective and also more rapidly induces repigmentation than targeted 311‐nm NB‐UVB for treatment of vitiligo.

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Long‐term efficacy and safety of tacrolimus ointment in the treatment of vitiligo

Cited by 6 publications

References 3 publications

Vitiligo nonsurgical treatment: a review of latest treatment researches

Vitiligo nonsurgical treatment: a review of latest treatment researches

The Epidemiology and Treatment of Vitiligo: A Chinese Perspective

Comparative efficacy between localized 308‐nm excimer light and targeted 311‐nm narrowband ultraviolet B phototherapy in vitiligo: A randomized, single‐blind comparison study

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