Long-term effects of transcranial direct current stimulation combined with computer-assisted cognitive training in healthy older adults

Park, See-Hyun; Seo, Jeong-Hwan; Kim, Yun-Hee; Ko, Myoung-Hwan

doi:10.1097/wnr.0000000000000080

Cited by 161 publications

(166 citation statements)

References 15 publications

(21 reference statements)

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“…It is known that after stroke may occur a change in synaptic homeostasis, which affects individuals' cognition (21) . In the present study the verbal and visual WM showed significant improvements after the use of tDCS, supporting the results found in diverse population by other authors (22,23) . One possible explanation is that the modulation of membrane action potencial induced by tDCS could limit this homeostasis lost, therefore mantaining the cognitive functions (24) .…”

Section: Discussionsupporting

confidence: 81%

Effects of transcranial direct current stimulation on the working memory of post-stroke people: an integrative review

Silva-Filho¹,

Albuquerque²,

Mescouto³

et al. 2020

mtprehabjournal

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Background: Stroke is a chronic disease that is becoming more common in all the world causing damage to people affected, for instance, cognitive deficits. The Transcranial Direct Current Stimulation (tDCS) is a form of treatment that modulates specific areas of the nervous system. Objective: The objective of this integrative review was to analyze the effectiveness of Transcranial Direct Current Stimulation (tDCS) on the working memory (WM) in post-stroke patients. Method: This review included articles that analyzed the effects of tDCS on human beings with a diagnosis of stroke and used as outcomes: verbal, visual, spatial or auditory WM. The assessment of studies elegibility was performed by two independent researchers from 8 databases: Cochrane Library via Wiley -CENTRAL, PubMed, LILACS, SCIELO, Web of Science, Scopus, CINAHL and PEDro following PRISMA guideline. Results: Three articles were included in the qualitative synthesis presenting a total of 66 participants (32 male and 34 female), 36 ischemic stroke and 30 hemorrhagic stroke with an average time of 42 days. Interventions were done on the areas F3/F4 (dorsolateral part of the prefrontal cortex) and T3/T4 (temporal anterior lobe) with 2mA current intensity for 30 minutes duration. The outcomes analyzed: verbal, visual, spatial, and auditory WM showed significant improvements after the use of tDCS. Conclusion: The limitations of this review were study designs, number of participants, lack of standardized interventions and short period of follow-up. tDCS showed satisfactory results on the WM of post-stroke individuals, but it is needed to be cautious due to the methodological quality of the articles. It is registered in the Prospective Register of Systematic Reviews -PROSPERO with registration number CDR42016048050.

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Section: Discussionsupporting

confidence: 81%

Effects of transcranial direct current stimulation on the working memory of post-stroke people: an integrative review

Silva-Filho¹,

Albuquerque²,

Mescouto³

et al. 2020

mtprehabjournal

View full text Add to dashboard Cite

show abstract

“…Two studies showed that training on one working memory task (n-back test) during tDCS improved performance on another working memory task (digit span) after stimulation [58,59]. Consistent with other findings in the neuromodulation literature, repeated sessions (a total of 10) of anodal tDCS have shown longterm improvement in working memory performance, lasting up to 4 weeks [59,60].…”

Section: Findings In Healthy Subjects and Patientssupporting

confidence: 70%

“…Montages were also different, with the most common placement situating the two electrodes over the F3 and F4 position on the international 10-20 EEG system. However, the paired electrode location differs across studies with the use of ipsilateral reference electrodes [67,80] or extra-cephalic arm electrodes [54,59,60,81]. These different montages also lead to important differences in the distribution of charge across studies.…”

Section: A Comment On Study Parameters and Designmentioning

confidence: 99%

“…As a result, not all subjects were passive during the stimulation, as some were either being tested or were being trained on another task [49,51,52,54,55,59,61,69,74,76,78,79,81,84]. A few studies also included long-term follow up to 1 year, to determine whether the changes persisted beyond the immediate post-stimulation period [50,59,60,70,72,84]. Finally the nature of the tests used also varied and executive functions were tested as a primary outcome, or as part of a battery of tests.…”

Section: A Comment On Study Parameters and Designmentioning

confidence: 99%

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Transcranial Direct Current Stimulation (tDCS): Modulation of Executive Function in Health and Disease

Sarkis

Kaur

Camprodon

2014

Curr Behav Neurosci Rep

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Transcranial direct current stimulation (tDCS) is a noninvasive method of neuromodulation used in human basic and clinical neuroscience. In this article we review its use in the cognitive neurosciences to study executive function, and current preliminary explorations of its therapeutic value as a cognitive enhancer for patients with compromised dysexecutive symptoms. We discuss published studies analyzing their methodology and results. A number of experiments describe improvement in experimental measures of inhibitory control, working memory, and verbal fluency with anodal stimulation over the dorsolateral prefrontal cortex. Positive findings are also described in different clinical populations. Despite the growing promise and interest in tDCS given its safety, simplicity, and low cost, findings are not always consistent across studies due to a host of variables we discuss (study design, stimulation parameters, neuroanatomy, genetics, etc.), highlighting the need for a better mechanistic understanding of the effects of tDCS.

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“…Neuroplasticity is a physiological property of the Central Nervous System (CNS) that allows to the brain to adapt to different stimulus and it's intrinsically linked to learning processes [18]. This plasticity capacitates the individual who has some neurological or psychiatric commitment to neurologically rearrange some functional capacities, showing previously lost abilities like, for example, the cognitive and motor rehabilitation on people who suffered a Cerebrovascular Accident (CVA) or Stroke [19,20].…”

Section: Introductionmentioning

confidence: 99%

Effects of the Transcranial Direct Current Stimulation on Prevention of Postoperative Cognitive Dysfunction after Cardiac Surgery: Prospective, Randomized, Double-Blind Study

Valentin¹

2015

JNSK

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Introduction: Postoperative cognitive dysfunction (POCD) is a contrary event observed between 20 to 83%, especially in elderly and after cardiac surgery. Prevention and rehabilitation on cases of POCD may improve the quality of life. The neuromodulator effect of the noninvasive cerebral stimulation has been used in the treatment of brain injuries, depression, and also in the cognitive rehabilitation. The hypothesis is that the use of the transcranial direct current stimulation (tDCS) technique can decrease the occurrence of POCD and cognitively rehabilitate patients submitted to cardiac surgeries. The objective of this study will be to evaluate the tDCS effect over the occurrence of POCD in patients on cardiac surgeries.

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Long-term effects of transcranial direct current stimulation combined with computer-assisted cognitive training in healthy older adults

Cited by 161 publications

References 15 publications

Effects of transcranial direct current stimulation on the working memory of post-stroke people: an integrative review

Effects of transcranial direct current stimulation on the working memory of post-stroke people: an integrative review

Transcranial Direct Current Stimulation (tDCS): Modulation of Executive Function in Health and Disease

Effects of the Transcranial Direct Current Stimulation on Prevention of Postoperative Cognitive Dysfunction after Cardiac Surgery: Prospective, Randomized, Double-Blind Study

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