Long-term Effects of Prenatal Cigarette Smoke Exposure on Behavior Dysregulation Among 14-Year-Old Offspring of Teenage Mothers

Cornelius, Marie D.; Goldschmidt, Lidush; Genna, Natacha M. De; Larkby, Cynthia

doi:10.1007/s10995-011-0766-0

Cited by 38 publications

(29 citation statements)

References 72 publications

(71 reference statements)

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“…Enhanced vulnerability of the PFC to the effects of PCSE would be consistent with findings of aggressive and impulsive behavior, hyperactivity, inattention, and impairments in executive function in children with PCSE (Batstra et al, 2003; Braun et al, 2008; Brook et al, 2006; Cornelius et al, 2011, 2012; Piper and Corbett, 2012) and with the specific effect of nicotine exposure on nicotinic cholinergic receptor expression in this region of the brain (Chen et al, 2005). The No-go N2 component has been proposed to reflect conflict processes taking place in or near the anterior cingulate cortex (Bekker et al, 2005; Donkers and van Boxtel., 2004; Jonkman et al, 2007; Nieuwenhuis et al, 2003).…”

Section: Discussionsupporting

confidence: 79%

Prenatal tobacco exposure and response inhibition in school-aged children: An event-related potential study

Boucher

Jacobson

Burden

et al. 2014

Neurotoxicology and Teratology

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Prenatal cigarette smoke exposure (PCSE) has been linked to problems in behavioral inhibition and attention deficit hyperactivity disorder in children in several epidemiological studies. We used event-related potentials (ERPs) to examine the effects of PCSE on neural correlates of inhibitory control of behavior. In a prospective longitudinal study on child development in the Canadian Arctic, we assessed 186 Inuit children (mean age = 11.3 years) on a visual Go/No-go response inhibition paradigm. PCSE was assessed through maternal recall. Potential confounders were documented from a maternal interview, and exposure to neurotoxic environmental contaminants was assessed from umbilical cord and child blood samples. PCSE was not related to behavioral performance on this simple response inhibition task. Nevertheless, this exposure was associated with smaller amplitudes of the N2 and P3 components elicited by No-go stimuli, suggesting an impairment in the neural processes underlying response inhibition. Amplitude of the No-go P3 component was also inversely associated with behavioral measures of externalizing problems and hyperactivity/impulsivity in the classroom. This study is the first to report neurophysiological evidence of impaired response inhibition in school-aged children exposed to tobacco smoke in utero. Effects were found on ERP components associated with conflict processing and inhibition of a prepotent response, indicating neurophysiological deficits that may play a critical role in the attention and behavior problems observed in children with PCSE.

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Section: Discussionsupporting

confidence: 79%

Prenatal tobacco exposure and response inhibition in school-aged children: An event-related potential study

Boucher

Jacobson

Burden

et al. 2014

Neurotoxicology and Teratology

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“…At the age 14-and 16-year assessments, the children reported their own behavior and substance use. Reports on maternal substance use, growth and behavioral outcomes of the offspring at birth, 6, 10, and 14 years have been provided elsewhere (Cornelius et al 2012). …”

Section: Methodsmentioning

confidence: 99%

Economic Hardship and Adolescent Problem Drinking: Family Processes as Mediating Influences

Hardaway

Cornelius

2013

J Youth Adolescence

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Alcohol is the most commonly used substance among adolescents in the United States, and adolescent drinking is associated with various health risk behaviors. Given the prevalence and consequences of adolescent drinking, understanding family factors that contribute to adolescent drinking is an important area for research. This study used three waves of data to evaluate a family stress model in which economic hardship is indirectly related to adolescent problem drinking through maternal psychological distress, parenting behaviors, and adolescent externalizing behaviors. Respondents included 300 mothers (71 % Black, 29 % White) and adolescents (51 % male) who were interviewed when adolescents were ages 10, 14, and 16. Structural equation modeling was used to test the hypothesized model and findings supported our hypothesized model. Economic hardship was positively related to maternal psychological distress. Maternal psychological distress was negatively associated with supportive parenting, which in turn was negatively associated with externalizing problems. Externalizing problems were positively associated with problem drinking. In support of our hypothesis regarding indirect effects, economic hardship was indirectly related to problem drinking through maternal psychological distress, parenting behaviors, and adolescent externalizing problems. The findings from this study highlight the role of family processes in adolescent problem drinking.

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“…The Institutional Review Boards of the Magee-Womens Hospital and the University of Pittsburgh approved each phase of this study. More detailed information on study protocol and sample descriptives can be found in other publications (Cornelius et al 2002;Cornelius et al 2012).…”

Section: Sample and Participant Selectionmentioning

confidence: 99%

Family Resources as Protective Factors for Low-Income Youth Exposed to Community Violence

Hardaway

Sterrett-Hong

Larkby

et al. 2016

J Youth Adolescence

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Exposure to community violence is a risk factor for internalizing and externalizing problems; however, resources within the family can decrease the likelihood that adolescents will experience internalizing and externalizing problems as a result of such exposure. This study investigates the potential moderating effects of kinship support (i.e., emotional and tangible support from extended family) and parental involvement on the relation between exposure to community violence (i.e., witnessing violence and violent victimization) and socioemotional adjustment (i.e., internalizing and externalizing problems) in low-income adolescents. The sample included 312 (50 % female; 71 % African American and 29 % White) low-income youth who participated in a longitudinal investigation when adolescents were age 14 (M age = 14.49 years) and again when they were 16 (M age = 16.49 years). Exposure to community violence at age 14 was related to more internalizing and externalizing problems at age 16. High levels of kinship support and parental involvement appeared to function as protective factors, weakening the association between exposure to violence and externalizing problems. Contrary to prediction, none of the hypothesized protective factors moderated the association between exposure to violence and internalizing problems. The results from this study suggest that both kinship support and parental involvement help buffer adolescents from externalizing problems that are associated with exposure to community violence.

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Long-term Effects of Prenatal Cigarette Smoke Exposure on Behavior Dysregulation Among 14-Year-Old Offspring of Teenage Mothers

Cited by 38 publications

References 72 publications

Prenatal tobacco exposure and response inhibition in school-aged children: An event-related potential study

Prenatal tobacco exposure and response inhibition in school-aged children: An event-related potential study

Economic Hardship and Adolescent Problem Drinking: Family Processes as Mediating Influences

Family Resources as Protective Factors for Low-Income Youth Exposed to Community Violence

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