Long-term effects of policosanol on older hypertensive patients with type II hypercholesterolemia

Más, Rosa; Castaño, Gladys; Fernández, Julio César; Illnait, José; Fernandez, Luisa; Alvarez, Estrella

doi:10.1046/j.1443-9506.2003.01776.x

Cited by 7 publications

(8 citation statements)

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“…However, HDL cholesterol was similar among experimental groups and control group. This may be partly attributable to that octacosanol regulate some enzymatic activities in lipid metabolism (Kato et al, 1995 andMas et al, 2004 ). These results were agreement with Peng et al (2016) who reported that a significant decrease of these traits by dietary supplementation of octacosanol in the diet of laying hens at levels of 18 mg or 27 mg octa /kg diet.…”

Section: Blood Traitssupporting

confidence: 85%

Effect of Octacosanol Supplementation on Productive and Physiological Performance of Aged Silver Montazah Strain During Summer Season

werdany

Mohamed²,

Habib³

et al. 2019

Journal of Productivity and Development

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The objective of this study was to evaluate the impact of supplementation levels (0, 8, 16 and 24 mg octacosanol (octa) / kg diet) on productive and physiological performance of aged Silver Montazah strain. A total number of 120 laying hens and 24 cocks of Silver Montazah local strain at 60 weeks of age was utilized in a completely randomized design and randomly assigned into 4 treatment groups (30 hens + 6 cocks in each treatment). Each group was divided into three replicates (10 hens and 2 cocks in each replicates). The 1 st group was fed the basal diet and served as the control group .The 2 nd , 3 rd and 4 th groups were fed the basal diet supplemented with 8, 16, and 24 mg octacosanol /kg diet respectively. The obtained results revealed that egg production percentage, egg mass, feed conversion ratios, concentrations of cholesterol, triglycerides, and LDL cholesterol, ovary weights, number of small yellow follicles (SYFs) and large white follicles (LWFs) were significantly (P≤0.05) improved by supplemented at levels of 16 mg or 24 mg octa /kg diet as compared with the control group. In addition, albumen height and Haugh unit were significantly (P≤0.05) improved than the control group at level of 24 mg octa /kg diet. Yolk diameter, concentrations of total protein, progesterone, estradiol, FSH, and LH, sperm cell concentration as well as sperm motility, dead spermatozoa, sperm abnormality and acrosomal 518 EL-WARDANY damage were significantly improved by increasing levels of octa when compared with the control group. Conclusively, it is clear that, supplementation of 16 mg octacosanol /kg diet is recommended for improving most of productive and reproductive traits, including egg production, some parameters egg quality, of semen quality and reduce serum lipid of laying hens, during summer season, under Inshas, Sharkia Province, Egypt environment conditions.

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Section: Blood Traitssupporting

confidence: 85%

Effect of Octacosanol Supplementation on Productive and Physiological Performance of Aged Silver Montazah Strain During Summer Season

werdany

Mohamed²,

Habib³

et al. 2019

Journal of Productivity and Development

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“…The ratio of TC/HDL-C was lowered by 27.1% and 27.5%, while HDL-C levels increased by 17.6% and 17.0%, respectively. In a recent study, Mas et al [28] reported that policosanol lowered LDL-C (29.5 %), TC (21.9 %), TG (16.9 %) and raised HDL-C (12.4 %) in older patients with type 2 DM. In addition, a few short-term studies indicated that the cholesterol-lowering effect of policosanol was better than that of statins such as simvastatin, pravastatin, lovastatin, probucol, or acipimox and with fewer side effects in patients with type II HC [27][28][29][30].…”

Section: Essential Alcohols: Policosanolmentioning

confidence: 95%

“…In a recent study, Mas et al [28] reported that policosanol lowered LDL-C (29.5 %), TC (21.9 %), TG (16.9 %) and raised HDL-C (12.4 %) in older patients with type 2 DM. In addition, a few short-term studies indicated that the cholesterol-lowering effect of policosanol was better than that of statins such as simvastatin, pravastatin, lovastatin, probucol, or acipimox and with fewer side effects in patients with type II HC [27][28][29][30]. Prat et al [31], Crespo et al [32] and Noa et al [33] reported that policosanol reduces intermittent claudication [27,34], platelet aggregation [35,36], diastolic blood pressure [DBP] and systolic blood pressure [SBP] [37,38] in older patients with hypertension and type II HC and dyslipidemia in type 2 DM [27,39]; and cerebral ischemia in animals [40].…”

Section: Essential Alcohols: Policosanolmentioning

confidence: 95%

Nutritional Supplements Modulating Metabolic Syndrome Risk Factors and the Prevention of Cardiovascular Disease

Juturu¹,

Gormley²

2005

CNF

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Metabolic syndrome risk factors (MSRF) can lead to cardiovascular disease (CVD) and its prevalence is increasing at an alarming rate in the United States and worldwide. Pathways leading directly from visceral adiposity to the genesis of free fatty acids and lipid accumulation are mediators of insulin resistance and hypertension. These conditions lead to a proinflammatory and prothrombotic state that can potentiate cardiovascular disease. Metabolic syndrome risk factors are interrelated and associated with predisposition to diabetes, obesity, hypertension and dyslipidemia and, thus, ultimately can lead to CVD. In this review, the authors focused on seven research-supported nutrients available as dietary supplements that offer potential benefits for people with MSRF. For the past two decades, a number of studies have evaluated the role of nutritional supplementation in the prevention of atherogenic and abnormal glucose risk factors. It is, therefore, important to identify strategies that favorably impact MSRF and disease conditions. This review focuses on nutritional compounds such as policosanol, soy proteins, plant stanols, plant esters and isoflavones, omega-3 fatty acids and chromium. These ingredients can beneficially modulate MSRF and, thus, potentially improve disease risk factors and related sequelae. Although the benefits of dietary supplements in general have not been comprehensively elucidated or established, it seems plausible, given available data, that non-pharmacological compounds exhibit the ability to measurably reduce MSRF and, consequently, provide potential protection against CVD and its associated complications.

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“…The studies varied in duration and sample population, and consistently showed reductions in serum LDL-C and TC levels of up to 44% and 29%, respectively (Crespo et al, 1997). Significant increases in serum HDL-C as compared to placebo were only reported in a few studies (Menendez et al, 1999b;Castano et al, 2001a;Mirkin et al, 2001) and reductions in serum triglycerides in only two (Castano et al, 2002c;Mas et al, 2004).The lipid-lowering potential of SCP tended to increase in a dose-dependant manner up to 20 mg/day. Beyond this dose, no further cholesterol reductions were observed, as reported in 2001 by…”

Section: Human Studies Investigating Policosanol Efficacymentioning

confidence: 98%

Evaluation of cholesterol-lowering and antioxidant properties of sugar cane policosanols in hamsters and humans

Kassis

2008

Appl. Physiol. Nutr. Metab.

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Atherosclerosis prevention is now a major focus of the scientific community and the pharmaceutical industry. Sugar cane policosanols (SCP) have gained increasing popularity over the last decade as a result of numerous studies conducted in Cuba considering SCP as the natural alternative to statin drugs. However, independent research on policosanols was not able to replicate cholesterol reductions reported by Cuban laboratories. No independent study to date has examined the cholesterol-lowering effect and antioxidant capacity of original SCP in humans. In addition, since independent research was criticized because of the use of alternative policosanol formulations, the source and composition of policosanol mixtures are now at the core of the policosanol controversy.The aim of the present thesis project was first to compare the composition and cholesterol-lowering effects of different SCP preparations in hamsters, and secondly to test the cholesterol-lowering efficacy, mechanism of action and antioxidant capacity of the original Cuban SCP in hypercholesterolemic humans.Study 1: Forty-eight male hamsters were randomly assigned to 4 groups for a period of 4 weeks (i) non-cholesterol control, (ii) cholesterol control, (iii) original SCP and (iv) alternative SCP. Hamsters were sacrificed and blood was collected at the end of the feeding period for lipid measurements.Study 2: Twenty-one hypercholesterolemic volunteers consumed 10 mg/day of SCP or a placebo for a period of 28 days in a crossover trial. Plasma lipid levels and LDL oxidation were measured at the start and end of supplementation phases. Cholesterol absorption and synthesis were assessed using single isotope single tracer technique and deuterium incorporation respectively.There was no significant difference in cholesterol-lowering efficacy between hamsters in the original and alternative SCP groups relative to control. Similarly, in hypercholesterolemic humans, original SCP supplementation did not significantly improve lipid parameters and no change in cholesterol absorption or synthesis was observed relative to control. In vivo assessment of LDL oxidation showed no significant changes in oxidized LDL concentration relative to baseline and control.

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Long-term effects of policosanol on older hypertensive patients with type II hypercholesterolemia

Cited by 7 publications

References 0 publications

Effect of Octacosanol Supplementation on Productive and Physiological Performance of Aged Silver Montazah Strain During Summer Season

Effect of Octacosanol Supplementation on Productive and Physiological Performance of Aged Silver Montazah Strain During Summer Season

Nutritional Supplements Modulating Metabolic Syndrome Risk Factors and the Prevention of Cardiovascular Disease

Evaluation of cholesterol-lowering and antioxidant properties of sugar cane policosanols in hamsters and humans

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