Long-term effects of levetiracetam and topiramate in clinical practice: A head-to-head comparison

Bootsma, H.P.R.; Ricker, Lukas J. A. G.; Diepman, L.; Gehring, Jacky; Hulsman, J.A.R.J.; Lambrechts, Danielle A.J.E.; Leenen, Loes; Majoie, Marian; Schellekens, A.; Krom, Marc de; Aldenkamp, Albert P.

doi:10.1016/j.seizure.2007.05.019

Cited by 62 publications

(57 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cognitive side effects can include impaired concentration [Froscher et al 2005], cognitive dulling [Coppola et al 2002], psychomotor slowing [Tatum et al 2001], language and comprehension problems [Fritz et al 2005], detrimental effects on short-term memory [Gomer et al 2007;Aldenkamp et al 2000] and working memory [Jung et al 2010;Lee et al 2006;Fritz et al 2005], poor verbal fluency [Jung et al 2010;Gomer et al 2007;Lee et al 2006Lee et al , 2003Fritz et al 2005;Thompson et al 2000] and wordfinding deficits [Mula et al 2003b], reduced IQ score [Sun et al 2008;Lee et al 2003;Thompson et al 2000] and cognitive speed [Bootsma et al 2008a;Gomer et al 2007], and abnormal thinking [Froscher et al 2005]. Other studies report improvements in cognitive measures after topiramate withdrawal [Kockelmann et al 2003].…”

Section: Pregabalinmentioning

confidence: 99%

The cognitive impact of antiepileptic drugs

Eddy¹,

Rickards²,

Cavanna³

2011

Ther Adv Neurol Disord

318

189

View full text Add to dashboard Cite

Effective treatment of epilepsy depends on medication compliance across a lifetime, and studies indicate that drug tolerability is a significant limiting factor in medication maintenance. Available antiepileptic drugs (AEDs) have the potential to exert detrimental effects on cognitive function and therefore compromise patient wellbeing. On the other hand, some agents may serve to enhance cognitive function. In this review paper, we highlight the range of effects on cognition linked to a variety of newer and older AEDs, encompassing key alterations in both specific executive abilities and broader neuropsychological functions. Importantly, the data reviewed suggest that the effects exerted by an AED could vary depending on both patient characteristics and drug-related variables. However, there are considerable difficulties in evaluating the available evidence. Many studies have failed to investigate the influence of patient and treatment variables on cognitive functioning. Other difficulties include variation across studies in relation to design, treatment group and assessment tools, poor reporting of methodology and poor specification of the cognitive abilities assessed. Focused and rigorous experimental designs including a range of cognitive measures assessing more precisely defined abilities are needed to fill the gaps in our knowledge and follow up reported patterns in the literature. Longitudinal studies are needed to improve our understanding of the influence of factors such as age, tolerance and the stability of cognitive effects. Future trials comparing the effects of commonly prescribed agents across patient subgroups will offer critical insight into the role of patient characteristics in determining the cognitive impact of particular AEDs.

show abstract

Section: Pregabalinmentioning

confidence: 99%

The cognitive impact of antiepileptic drugs

Eddy¹,

Rickards²,

Cavanna³

2011

Ther Adv Neurol Disord

318

189

View full text Add to dashboard Cite

show abstract

“…42 A comparison of levetiracetam (n = 304) and topiramate (n = 470) was conducted by Bootsma and colleagues. 43 The objective was to evaluate the long term effects of the medication between the two drugs on partial onset and generalized seizures. A follow-up period of 24 months was used, with evaluation every 6 months.…”

Section: Long-term Therapy In Adultsmentioning

confidence: 99%

“…Due to neurocognitive side effects, twice as many patients stopped taking topiramate as levetiracetam during the study. 43 Additional studies are being conducted that evaluate long-term efficacy of levetiracetam. Based on the data available at present (Table 3), levetiracetam appears to be safe and effective long-term treatment (1 year) and can be safely continued for epilepsy treatment.…”

Section: Long-term Therapy In Adultsmentioning

confidence: 99%

Pharmacotherapy of Epilepsy: Focus on Levetiracetam

Adams

Chung

Eiland

2009

Clinical Medicine. Therapeutics

View full text Add to dashboard Cite

Abstract:Levetiracetam is a second-generation antiepileptic drug which first came to the United States market in 1999. It has a mechanism of action that is not well elucidated. However, it is a very favorable antiepileptic drug due to its reliable pharmacokinetics, minimal drug interactions, seizure efficacy and good tolerability. It is an agent that has established efficacy as an adjunct therapy agent for partial and refractory seizures. As a monotherapy agent, levetiracetam also appears to be an attractive agent with observed efficacy and tolerability. Since levetiracetam has recently become available intravenously, it is also being reviewed as an agent for acute status epilepticus. In pediatrics, levetiracetam is widely used with efficacy seen in small clinical trials for a variety of seizure types. Levetiracetam is well tolerated: the most common adverse effect being somnolence and behavioral effects. Overall, levetiracetam is a notable antiepileptic drug that has added significantly to the current antiepileptic armamentarium.

show abstract

“…3 The antiepileptic drugs used currently frequently cause unwanted effects that range in severity from minimal impairement of central nervous system to death from aplastic anemia or hepatic failure. 4 Approximately one third of patients with epilepsy do not respond to treatment with a single anti-epileptic drug and it becomes necessary to try a combination of drugs to control seizures. 5 Tirunelveli Medical College hospital is a tertiary care teaching hospital.…”

Section: Introductionmentioning

confidence: 99%