Long-Term Effects of Intravitreal Infliximab for Treatment of Sight-Threatening Chronic Noninfectious Uveitis

Abstract

Intravitreal Infliximab may be used in treatment of noninfectious uveitis. It probably improves the vision and decreases the macular edema but its effect is temporary and repeated injections may be needed to achieve the best therapeutic goal.

Anti–tumor necrosis factor-α therapy in uveitis

“…46,47 The other also employed a single intravitreal injection of infliximab with a different dose, 1 mg/0.05 mL. 85 A single intravitreal injection of infliximab produced a significant improvement in visual acuity, vitreous inflammation scores, and central macular thickness (CMT) at one month in both studies; however, these results were not maintained at the 6-month end-point.…”

“…Local delivery may maximize results and minimize potential side-effects although preliminary results have not been very encouraging. 3,46,47,85 In general, we need larger randomized studies with longer follow-up that include more homogeneous groups of uveitis patients. There are still many unanswered questions about the use of anti-TNF-α therapy for non-infectious uveitis.…”

Cytokine Profiles in Aqueous Humor and Plasma of HIV-infected Individuals with Ocular Syphilis or Cytomegalovirus Retinitis

“…Intravitreal drugs targeting different cytokines for the treatment of local inflammation in chronic non-infectious uveitis have given promising results. [34][35][36][37][38] Identification of the cytokines involved in the pathogenesis of different OIs in HIV-infected individuals has important implications for the development of drugs targeting these cytokines, particularly in cases of persistent inflammation after successful treatment of active ocular infections.…”

Ocular Manifestations of Behçet’s Disease

“…Infliximab has been suggested to be a promising agent for refractory eye disease in combination with other immunosuppressants. It is important to be cautious for reactivation of tuberculosis [89][90][91][92][93][94].…”