Long-Term Effects of Intense Pulsed Light Combined with Meibomian Gland Expression in the Treatment of Meibomian Gland Dysfunction

Rong, Bei; Tang, Yueh‐Bih; Liu, Ruixing; Tu, Ping; Qiao, Jing; Song, Wenjing; Yan, Xiaoming

doi:10.1089/pho.2018.4499

Cited by 67 publications

(118 citation statements)

References 24 publications

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“…Its application improved in the following years, being proposed in 2002 possible bene its in ophthalmic diseases [3][4][5]. Ophthalmologist Rolando Toyos was the irst to suggest the use of IPL for the treatment of MGD, from the observation of objective and subjective improvement of DES symptoms in patients with periocular rosacea undergoing Pulsed Light therapy [8][9][10]. However, it has been proven that the effectiveness of treatment in the evaporative dry eye is independent of the presence of a previous dermatological lesion.…”

Section: Ipl Therapymentioning

confidence: 99%

“…The device uses a broad-spectrum polychromatic light source with a wavelength of 500-1.200 nm, selectively absorbed by various chromophores (hemoglobin, melanin, and water) in the skin. This light is iltered by the source equipment to allow selective wavelength emission [9].…”

Section: Ipl Therapymentioning

confidence: 99%

“…, modulation and secretion of pro and anti-in lammatory molecules, suppression of matrix metalloproteases, and release of reactive oxidative species [1,3]. The most widely accepted hypothesis deals with thrombosis of abnormal blood vessels by transforming light absorbed by hemoglobin into heat, reducing the reserve of in lammatory mediators in the eyelid and meibomian glands [9][10][11]. The temperature of the eyelid physically in luences the meibum.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

“…A recent alternative implemented in the treatment of MGD is the use of Intense Pulsed Light (IPL). It consists of the emission of visible, high-intensity polychromatic light at wavelengths of 500-1200nm, through equipment adapted with xenon lash lamp [7][8][9]. The emitted light is capable of producing perfectly calibrated and homogeneous light pulse sequences.…”

Section: Introductionmentioning

confidence: 99%

“…The bene its of conventional treatments and long-term IPL were compared. Prospective studies currently require signi icant samples to validate the real impact of this therapy [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Dry eye syndrome: Therapeutic challenges and future trends

Araújo-Neto¹,

Rêgo²,

Araújo‐Filho³

2019

Int J Clin Exp Ophthalmol

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Introduction:Intense Pulsed Light (IPL) is the therapeutic tool implemented in the treatment of dry eye, characterized by the emission of waves of 500-1200nm in the region of the upper and lower eyelids. Dry eye is a recurring complaint in ophthalmology offi ces and has an impact on the patient's quality of life. It results from dysfunction of the meibomian glands, duct obstruction, and quantitative and qualitative changes in glandular secretion. It is manifested by dryness and irritation, foreign body sensation, burning, tearing, and eye fatigue. The available treatments are short term palliative with unsatisfactory results. Objective:To determine through a literature review, the benefi t of using intense pulsed light for dry eye treatment. Methodology: We searched the Cochrane database, PubMed, Embase, Scopus, Web of Science, and Google Scholar (gray literature) using the keywords for an independent, blinded, peer-reviewed selection of articles to be met following pre-established criteria.Results and discussion: Studies evaluated the use of IPL in patients with dry eye, despite the benefi t found, focus on the objective and subjective assessment of the eye more frequently. Conclusion:Evidence-based clinical guidelines are required for the use of intense pulsed light in the treatment of Meibomian Gland Dysfunction (MGD), as well as a device and algorithm for indications of therapeutic use. Dry eye syndrome: Therapeutic challenges and future trends

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Section: Ipl Therapymentioning

confidence: 99%

Section: Ipl Therapymentioning

confidence: 99%

Section: Mechanisms Of Actionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The bene its of conventional treatments and long-term IPL were compared. Prospective studies currently require signi icant samples to validate the real impact of this therapy [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dry eye syndrome: Therapeutic challenges and future trends

Araújo-Neto¹,

Rêgo²,

Araújo‐Filho³

2019

Int J Clin Exp Ophthalmol

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Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction

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Zhang

Ahmadzai

et al. 2020

Cochrane Database of Systematic Reviews

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Prediction of potential drugs and targets based on meibomian gland dysfunction module classification to guide individualized treatment

Zhao

Gao

et al. 2019

J of Cellular Biochemistry

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Meibomian gland dysfunction (MGD) is an epidemic chronic ocular inflammation. However, little is known about its effective treatment. Here, this study identified important MGD‐related genes, core regulators, and potential drugs and their targets though integrating a series of bioinformational analyses. First, there were 665 differentially expression genes (DEGs) were identified. Then, 56 coexpression modules were exacted based on the expression of DEGs and their interactors. Moreover, core transcription factors (TF) significantly regulated modules were identified, including RELA, HIF1A, SIRT1, and MYC, which related to variety of eye diseases. Finally, the prediction of potential drugs and the identification of their target were performed. The results showed that artenimol, copper, and glutathione may have the remarkable curative effect or the toxicology to MGD. Moreover, their targets module gene LDHA (lactate dehydrogenase A), ENO1 (enolase 1), ALB (albumin), and PKM (pyruvate kinase M) are play important role in eye diseases. It suggests that these potential drugs may be useful for the treatment of MGD by acting on their targets. It provides valuable references for drug redirection and new drug development for drug developers, and provides individualized treatment strategies for tarsal gland dysfunction.

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Long-Term Effects of Intense Pulsed Light Combined with Meibomian Gland Expression in the Treatment of Meibomian Gland Dysfunction

Cited by 67 publications

References 24 publications

Dry eye syndrome: Therapeutic challenges and future trends

Dry eye syndrome: Therapeutic challenges and future trends

Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction

Prediction of potential drugs and targets based on meibomian gland dysfunction module classification to guide individualized treatment

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