Long-term effects of Helicobacter pylori eradication in Mongolian gerbils

Hirayama, Fumihiro; Takagi, Shiro; Yokoyama, Yoshito; Yamamoto, Kenji; Iwao, Eiji; Haga, Keiichiro

doi:10.1007/s005350200130

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…Yamagata Prefecture therefore has attempted aggressively to achieve secondary prevention of gastric cancer. In 1994, IARC/WHO concluded that Helicobacter pylori (H pylori) is a definite carcinogen in humans [2] , and the results of a prospective cohort study [3] and animal studies [4][5][6] have demonstrated that H pylori causes gastric cancer. The possible role of H pylori eradication therapy in primary prevention of gastric cancer has thus attracted substantial interest in Yamagata Prefecture.…”

Section: Introductionmentioning

confidence: 99%

Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?

Mabe¹,

Takahashi²,

Oizumi³

et al. 2009

WJG

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Section: Introductionmentioning

confidence: 99%

Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?

Mabe¹,

Takahashi²,

Oizumi³

et al. 2009

WJG

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“…Therefore, it is important to evaluate GIM, which is generally thought to be a precancerous condition in gastric cancer (12,18). Furthermore, a previous study has shown that GIM is closely associated with Helicobacter pylori infection (31). However, little is known about the genetic events responsible for initiation and progression of gastric cancer (32,33).…”

Section: Discussionmentioning

confidence: 99%

Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa

Sugai¹

2009

Oncol Rep

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Abstract. The biological properties and underlying genetics of gastric cancer and gastric intestinal metaplasia evolve with neoplastic progression from the genetics of the original gland cell. PCR assay with crypt isolation was used in tumors from 20 patients to examine microsatellite alterations (allelic imbalance at 17p, 5q, 18q, 3p, 4p, and 9p, and microsatellite instability) in glands from each tumor and from intestinal metaplastic lesions. Tumor specimens were processed as either pooled-gland samples or single-gland samples. Pooled gland sample was composed of 10-20 tumor glands, intestinal metaplastic glands, or nonmetaplastic glands. Single gland sample was 10 tumor glands from tumor and single gland sample was 5 gastric intestinal metaplastic and 5 nonmetaplastic glands from its surrounding metaplastic mucosa. Multiple genetic alterations were found in individual tumor glands, with various subclonal expansions seen within the same tumor. Although microsatellite instability was found in 2 of 20 tumor single-gland samples, none was detected in metaplastic single-gland samples. Most cancers appear to have a heterogeneous composition. On the other hand, microsatellite alterations were also detected within the nonmetaplastic as well as intestinal metaplastic single-gland samples.In conclusion, the present data on tumor and corresponding intestinal metaplastic and nonmetaplastic glands suggest that genetic alterations already occur within the surrounding of the noncancerous mucosa.

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“…However, molecular markers have not been thoroughly explored with regard to the pathogenesis of the lesions in gerbils, and longer follow-up is now necessary to confirm the long-term benefit of eradication treatment. 31) This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare, Japan, and a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan. X.C.…”

Section: Discussionmentioning

confidence: 99%

Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils

Cao¹,

Tsukamoto²,

Nozaki³

et al. 2004

Cancer Science

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Mongolian gerbils infected with Helicobacter pylori (H. pylori) develop heterotopic proliferative glands (HPGs) in the glandular stomach submucosa. To investigate the effects of H. pylori eradication on cell turnover in HPGs, three antibiotics, lansoprazole, amoxicillin and clarithromycin, were administered at 50 or 75 weeks after inoculation of H. pylori, and the stomachs were excised for histological examination at 1, 2, 4, 8 or 25 weeks thereafter. The HPGs were classified into gastric type (G-type) and others (GI + + + +I-type), which included both pure intestinal (I-type) and gastric-and-intestinal mixed type (GI-type). Apoptosis and cell proliferation were evaluated by means of TUNEL assay and BrdU labeling, respectively. At 8 weeks post-eradication, apoptotic indices were significantly increased in the eradication group (G-type: 2.5%; GI + + + +I-type: 7.2%) compared to the non-eradication group (G-type: 0.6%; GI + + + +I-type: 2.1%: P < < < <0.01), while BrdU labeling indices were significantly decreased (G-type: 1.9%; GI + + + +I-type: 6.8% as compared with 4.3% and 13.2%, respectively, P < < < <0.01 for both). At 25 weeks, the apoptotic indices were similarly higher [G-type: 0.4 (eradication group) vs. 0.2% (non-eradication group); GI + + + +I-type: 5.8 vs. 1.1%, both P < < < <0.01], and the BrdU labeling indices (G-type: 0.8 vs. 2.2%, P < < < <0.01; GI + + + +I-type: 5.1 vs. 11%, P < < < <0.05) continued to be lower in HPGs. elicobacter pylori (H. pylori) infection has been implicated as a major cause of chronic gastritis and a strong risk factor for gastric adenocarcinoma. Epidemiological and experimental studies have demonstrated associations between H. pylori infection and the development of chronic superficial gastritis, atrophic gastritis and intestinal metaplasia.

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Long-term effects of Helicobacter pylori eradication in Mongolian gerbils

Abstract: These results suggest that H. pylori eradication may have had a therapeutic effect not only on gastritis, erosion, and gastric ulcer but also on glandular atrophy, intestinal metaplasia, and gastric carcinoid.

Cited by 11 publications

References 23 publications

Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?

Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?

Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa

Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils

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