Long-term effects of glans penis augmentation using injectable hyaluronic acid gel for premature ejaculation

Kwak, Tae Il; Jin, Myeong Heon; Kim, J J; Moon, Du Geon

doi:10.1038/ijir.2008.26

Cited by 68 publications

(53 citation statements)

References 18 publications

(17 reference statements)

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“…A surgical procedure consisting of a dorsal neurectomy with or without granular augmentation with hyaluronic acid gel has been reported to improve PE [56]. Although positive results have been reported with significantly increased IELT, the two groups that underwent dorsal neurectomy or dorsal neurectomy and glandular augmentation, both had significant side effects, including penile numbness, paresthesia and pain, whereas the group that underwent hyaluronic acid augmentation alone reported no adverse side effects.…”

Section: Experimental Pe Treatment Optionsmentioning

confidence: 91%

Neurogenic Ejaculatory Disorders: Focus on Current and Future Treatments

Calabrò

Polimeni²,

Casella

et al. 2011

RPCN

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Ejaculation is a complex and still poorly understood neurological mechanism, at both spinal and cerebral levels as it is closely associated with orgasm. Physiologically, ejaculation is defined as the expulsion of seminal fluid from the urethral meatus and consists of two phases, namely emission and expulsion. Ejaculation is mediated by a spinal control center, referred to as a spinal pattern generator that coordinates sympathetic, parasympathetic and motor (somatic) outflows, integrating the latter with the inputs from the supraspinal sites in brainstem, hypothalamus and preoptic area. Premature ejaculation (PE) is the most common sexual dysfunction among young men, and it has been considered mostly psychogenic in origin, although it can be associated to diverse urological and neurological diseases. On the contrary, retrograde ejaculation and anejaculation are predominantly related to organic causes, particularly to neurogenic ones. Since ejaculation is mostly a spinal reflex, it is comprehensible that ejaculatory disorders are more frequent in spinal cord injury than in other neurological disorders. Over the past decades, research has focused on PE, and evidence from clinical studies showed a beneficial effect of antidepressants for the treatment of men with PE. Other ejaculatory disorders, especially painful ejaculation, have been less investigated and the proper therapy is still controversial. Aim of this review is to provide a comprehensive description of both currently available treatments and most promising future therapies, including assigned patents, for the neurogenic ejaculatory disorders.

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Section: Experimental Pe Treatment Optionsmentioning

confidence: 91%

Neurogenic Ejaculatory Disorders: Focus on Current and Future Treatments

Calabrò

Polimeni²,

Casella

et al. 2011

RPCN

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show abstract

“…The group that underwent hyaluronic acid augmentation alone reported no adverse side effects. Five years study on the glans augmentation arm of the trial and the hyaluronic acid implants were well maintained, showing long-term efficacy (Kwak et al, 2008). The role of surgery in the management of PE remains unclear, and thus further trials are needed before its role can be established.…”

Section: Emerging and Experimental Treatment Options For Pementioning

confidence: 99%

Premature Ejaculation Re-Visited: Definition and Contemporary Management Approaches

Al-Shaiji¹

2012

Erectile Dysfunction - Disease-Associated Mechanisms and Novel Insights Into Therapy

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“…Short of invasive procedures such as augmentation of the glans penis with hyaluronic gel to induce long-term penile hypoaesthesia, 17,18 there is no convincing evidence that any pharmacological treatment to date offers a 'cure' for PE. The American Urological Association (AUA 2004) guidelines on the management of PE 19 suggest that the risks and benefits of all therapeutic options should be presented to the patient (and partner) so that an educated treatment choice may be made by the patient in consultation with the physician.…”

Section: Introductionmentioning

confidence: 99%

‘Up and coming’ treatments for premature ejaculation: progress towards an approved therapy

Powell¹,

Wyllie

2009

Int J Impot Res

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It is generally accepted that premature ejaculation (PE) is a more common problem than erectile dysfunction, although at present the options currently available for the treatment of PE are limited to behavioural psychotherapy and 'off-label' prescribing of pharmacological therapies. A sexual complaint with such a high prevalence together with an increasing understanding of the psychosocial consequences of PE has naturally stimulated the interest of the pharmaceutical industry and the first products designed specifically for the treatment of PE are either in late-stage clinical development or are already under regulatory review. Most of the new treatments for PE have been developed for 'on-demand' use, which may prove to offer the most favourable risk: benefit profile as well as the flexibility to adapt to differing frequencies of sexual activity. This paper reviews a number of emerging therapies in various stages of development that show potential for use in the treatment of PE.

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Long-term effects of glans penis augmentation using injectable hyaluronic acid gel for premature ejaculation

Cited by 68 publications

References 18 publications

Neurogenic Ejaculatory Disorders: Focus on Current and Future Treatments

Neurogenic Ejaculatory Disorders: Focus on Current and Future Treatments

Premature Ejaculation Re-Visited: Definition and Contemporary Management Approaches

‘Up and coming’ treatments for premature ejaculation: progress towards an approved therapy

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