Long-Term Effects of ELF Magnetic Fields on the Mouse Testis and Serum Testosterone Levels

Picazo, M. L.; Miguel, María P. De; Leyton, V.; Franco, P.; Varela, L.; Paniagua, Ricardo; Bardasano, J. L.

doi:10.3109/15368379509022552

Cited by 19 publications

(9 citation statements)

References 10 publications

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“…In another experiment, the same working group exposed rats for 8 months (8 h/day, 5 days/week) to a 50-Hz MF of 5 or 100 µT and they also did not observed any MF-related alterations in testicular histology [3]. However, Picazo et al [4] reported a significant increase in the size and weight of the testicles (due to an increase in the interstitial tissue) and elevated levels of serum T after a 10-week exposure of 50-Hz/100-µT MF. Sert et al [5] also found increased T levels in rats that they left for 5 weeks, 3 h/day in a 50-Hz/0.8-mT MF.…”

Section: Forgács Et Al: Magnetic Field Effect On Mouse Leydig Cellsmentioning

confidence: 92%

Effects of Whole-Body 50-Hz Magnetic Field Exposure on Mouse Leydig Cells

Forgács¹,

Somosy

Kubinyi

et al. 2004

The Scientific World JOURNAL

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The main goal of this study was to evaluate the possible effect of whole-body magnetic field (MF) exposure on the steroidogenic capacity of Leydig cells in vitro. In four separate experiments, male CFLP mice were exposed to sinusoidal 50-Hz, 100-μT MF. The duration of exposure was 23.5 h/day over a period of 14 days. At the end of the exposure, interstitial (Leydig) cells were isolated from the testicles of the sham-exposed and exposed animals. The cells were cultured for 48 h in the presence or absence of 1, 10, or 100 mIU/ml human chorionic gonadotropin (hCG). The luteinizing hormone (LH) analog hCG was used to check the testosterone (T) response of the sham-exposed controls and to evaluate the possible effect of the whole-body MF exposure on the steroidogenic capacity of Leydig cells in vitro. Testosterone content of the culture media and blood sera was measured by radioimmunoassay (RIA). In the cultures obtained from MF-exposed animals, the hCG-stimulated T response was significanly higher (p < 0.01) compared with the sham-exposed controls, while the basal T production of cells and the level of serum T remained unaltered. No MF exposure—related histopathological alterations were found in testicles, epididymes, adrenals, prostates, and pituitary glands. The MF exposure did not affect the animal growth rate and the observed hematologic and serum chemical variables. Our results indicate a presumably direct effect of whole-body MF exposure on the hCG-stimulated steroidogenic response of mouse Leydig cells.

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Section: Forgács Et Al: Magnetic Field Effect On Mouse Leydig Cellsmentioning

confidence: 92%

Effects of Whole-Body 50-Hz Magnetic Field Exposure on Mouse Leydig Cells

Forgács¹,

Somosy

Kubinyi

et al. 2004

The Scientific World JOURNAL

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“…8 Regarding the endocrine system, the sensitivity of pineal gland, pituitary gland, adrenal gland and thyroid gland as well as of the endocrine pancreas, testicles and ovaries to EMFs have been investigated. [9][10][11][12][13][14][15][16][17][18][19][20][21] The thyroid gland is one of the most exposed and vital organs and may be a target for any type of electromagnetic radiation. 22 It has been established that even a small change in thyroid hormone levels circulating in the blood are sufficient to alter the brain function of subjects.…”

Section: Introductionmentioning

confidence: 99%

Alterations in TSH and Thyroid Hormones following Mobile Phone Use

Mortavazi¹,

Habib²,

Ganj-Karami³

et al. 2009

OMJ

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As far as the study is concerned, this is the first human study to assess the associations between mobile phone use and alterations in the levels of TSH and thyroid hormones. Based on the findings, a higher than normal TSH level, low mean T4 and normal T3 concentrations in mobile users were observed. It seems that minor degrees of thyroid dysfunction with a compensatory rise in TSH may occur following excessive use of mobile phones. It may be concluded that possible deleterious effects of mobile microwaves on hypothalamic-pituitary-thyroid axis affects the levels of these hormones.

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“…In another study, a significant increase in the size and weight of testes was related to an increase in the amount of interstitial tissue. Elevated testosterone levels after a 10-week exposure to 50 Hz of 100 μT MF was also observed [94].…”

Section: Cell Proliferation and Emf Exposurementioning

confidence: 83%

The Effects of Extremely Low-Frequency Magnetic Fields on Reproductive Function in Rodents

Lee¹,

Park²,

Kim³

2016

Insights From Animal Reproduction

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Extremely low-frequency electromagnetic fields (ELF-EMF) are defined as those having frequencies up to 300 Hz, representing a non-ionising radiation having photon energy too weak to interact with biomolecular systems. Exposure to low-frequency electric field and magnetic field (MF) generally results in negligible energy absorption in the body. However, it is well established that ELF-MF induces biologic effects in various cellular functions. ELF-MF acting as a co-inducer can potentiate weak mutagenic signalling. The concern about possible adverse effects on human health of long-term exposure to ELF-MFs, especially at frequencies of 50 or 60 Hz generated from power lines and electric devices, has been increasing. Conversely, long-term effects of chronic exposure have been excluded from the scope of the guidelines of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) because of insufficient consistent scientific evidence to fix the thresholds for such possible biological effects. The results regarding the adverse effects of ELF-MF on human or animal reproductive functions are contradictory or inconclusive. Overall conclusion of epidemiologic studies on ambient residential MF exposure consistently failed to establish a link between human adverse reproductive outcomes and chronic maternal or paternal exposure to low-frequency MFs. In animal studies, there is no compelling evidence for a causal relationship between disturbed prenatal development and ELF-MF exposure. Testicular spermatogenesis progresses through a complexly regulated cellular process involving mitosis and meiosis; this process seems to be vulnerable to external stressors, such as heat, MF exposure or chemical and physical agents. Exposure to ELF-MF did significant risk impaired implantation or the foetal development in animal studies. However, there is some consistency in the increase of minor skeletal alterations in animal experiments. The evidence derived from recent studies in male mice demonstrates that ELF-MF exposure is involved with an increase in the frequency of apoptosis in spermatogenic cells. Those results suggest that exposure to MF is related to possible cytogenetic effects on testicular germ cells and therefore may negatively affect reproduction. This chapter intends to present an overview on the effects of ELF-EMF exposure on the reproductive function and a plausible mechanism in rodent species.

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Long-Term Effects of ELF Magnetic Fields on the Mouse Testis and Serum Testosterone Levels

Cited by 19 publications

References 10 publications

Effects of Whole-Body 50-Hz Magnetic Field Exposure on Mouse Leydig Cells

Effects of Whole-Body 50-Hz Magnetic Field Exposure on Mouse Leydig Cells

Alterations in TSH and Thyroid Hormones following Mobile Phone Use

The Effects of Extremely Low-Frequency Magnetic Fields on Reproductive Function in Rodents

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