Long-Term Effects of Dichloromethylene Diphosphonate (Cl2 DP) on skeletal Lesions in Multiple Myeloma

Delmas, Pierre D.; Charhon, S; Chapuy, M. C.; Vignon, E.; Briançon, D.; Edouard, C.; Meunier, Pierre J.

doi:10.1016/0221-8747(82)90013-3

Cited by 123 publications

(30 citation statements)

References 17 publications

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“…This difficulty was well illustrated by conflicting results recently published by authors who tried to relate bone resorbing activity measured in vitro to the presenting features of myeloma patients (especially the extent of bone lesions and disease activity) (Schecter et al, 1980;Durie et al, 1981). Other explanations of these discrepancies could be that some myeloma patients have a very indolent disease at diagnosis in spite of lesions on bone radiography (Alexanian, 1980) (Delmas et al, 1982). In future, the early detection of myeloma patients with very active bone resorption will be necessary, as a rational prerequisite for the combination of anticancer and antiosteoclastic drugs as a primary treatment of MM.…”

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confidence: 99%

In vitro osteolytic activity of human myeloma plasma cells and the clinical evaluation of myeloma osteoclastic bone lesions

Jf¹,

Bataille²

1984

Br J Cancer

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confidence: 99%

In vitro osteolytic activity of human myeloma plasma cells and the clinical evaluation of myeloma osteoclastic bone lesions

Jf¹,

Bataille²

1984

Br J Cancer

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“…1977 and has been used to prevent bone loss in multiple myeloma [Siris et al. 1980;Delmas et al. 1982], Paget's disease [Meunier etal.. 1979;Adami etal., 1984] and experimental osteopor osis [Michael et al.…”

Section: Introductionmentioning

confidence: 99%

A Scanning Electron-Microscopic Study of Femoral Bone Surfaces from Castrate Rats Treated with Dichloromethylene Biphosphonate

Wink¹

1986

Cells Tissues Organs

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This study compared SEM appearances of endosteal and periosteal surfaces of anorganic femoral diaphyses from three groups of adult male rats: (1) control; (2) castrate (osteoporotic), and (3) castrate + injections of dichloromethylene biphosphonate (Cl₂entrances; (2) area of vascular canal entrances; (3) number of osteoblast lacunae, and (4) percent area of bone surface types. Endosteal surfaces from untreated osteoporotic rats had significantly more osteoblast lacunae, larger vascular canal entrances, and less resting surface than those of the other groups. There were no differences in endosteal surfaces between controls and Cl₂MBP-treated castrates. Periosteal surfaces demonstrated no significant differences in percent area of bone surface types between groups, untreated castrates had more osteoblast lacunae than other groups, and vascular canal entrances were smaller in castrate groups than in controls. Castrates treated with C1₂MBP had significantly fewer periosteal vascular canal entrances, and many canal entrances and osteoblast lacunae appeared to be plugged with mineral deposits when compared with the other groups. The results indicate that C1₂MBP treatment prevented endosteal bone surface changes that occurred with castration osteoporosis, and may have disrupted normal vascularization on periosteal surfaces.

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“…The fact that the distribution of TBV in our population of MM was normal and that 2 of these patients did not have any myeloma cells in their UTBB would indicate an osteoporosis accidentally associated with haematological disease (see below), leading to therapy other than chemotherapy. In spite of the fact that sodium fluoride, calcium and vitamin D did not improve a large population of MM (Cohen et al, 1984), this special subset of patients could take advantage of this type of specific treatment, perhaps alternating with antiosteoclastic drugs such as diphosphonates, already proven useful in MM (Delmas et al, 1982;Radl et al, 1985). The opposite feature (i.e.…”

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Importance of quantitative histology of bone changes in monoclonal gammopathy

Bataille¹,

Chappard²,

Alexandre³

et al. 1986

Br J Cancer

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Quantitative histology of bone changes, using undecalcified transiliac bone biopsies (UTBB), was performed blindly in 46 individuals with monoclonal gammopathy (MG), including 17 with MG of undetermined significance (MGUS) and 29 with overt multiple myeloma (MM). Three MGUS presented an excess of osteoclastic resorption (OR) in the vicinity of clusters of tumour cells and developed overt B cell malignancies, chronic lymphocytic leukaemia, WaldenstrÃ¶m's disease and MM respectively. On the other hand, MGUS with normal OR remained stable (median follow-up = 28 months), with one exception who developed a systemic amyloidosis. In MM, excessive OR was only observed in areas invaded by myeloma cells. OR was frequently normal in active MM lacking myeloma cells in UTBB. Active MM without lesions on radiography had excessive OR. IgA and pure Bence Jones MM appeared more osteoclastic than IgG cases (P less than 0.05). Of major interest was the finding that one third of MM presented histological bone changes similar to osteoporosis, osteosclerosis or osteoblastic metastasis. Two major findings must be emphasized from the current data: UTBB could be of major interest for the early detection of a B cell malignancy; heterogeneity of myeloma bone condition is unexpected. If some changes appear directly related to the tumour (i.e. excessive OR or osteoblastic dysfunction), some others are probably accidentally associated with it (i.e. osteoporosis), both needing treatment other than chemotherapy.

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Long-Term Effects of Dichloromethylene Diphosphonate (Cl2 DP) on skeletal Lesions in Multiple Myeloma

Cited by 123 publications

References 17 publications

In vitro osteolytic activity of human myeloma plasma cells and the clinical evaluation of myeloma osteoclastic bone lesions

In vitro osteolytic activity of human myeloma plasma cells and the clinical evaluation of myeloma osteoclastic bone lesions

A Scanning Electron-Microscopic Study of Femoral Bone Surfaces from Castrate Rats Treated with Dichloromethylene Biphosphonate

Importance of quantitative histology of bone changes in monoclonal gammopathy

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