Long-term effects of curcumin in the non-human primate brain

Koo, Bang‐Bon; Calderazzo, Samantha; Bowley, Bethany; Kolli, Alekha; Moss, Mark B.; Rosene, Douglas L.; Moore, Tara

doi:10.1016/j.brainresbull.2018.06.015

Cited by 12 publications

(8 citation statements)

References 79 publications

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“…For a direct neuroprotective role, curcumin significantly ameliorated white matter injury, reduced the loss of preoligodendrocytes, and decreased activated microglia in LPS-treated neonatal rats, which is associated with suppression of inducible nitric oxide synthase (iNOS) and NADPH oxidase (NOX) activation [ 47 ]. In the nonhuman primate model of normal aging, long-term curcumin treatment increased grey matter density in cortical ROIs (regions of interests) and improved white matter integrity in limbic, cerebellar, and brain stem regions, providing a neurological basis for the improvements of spatial working memory and motor function in aging nonhuman primates treated with curcumin [ 48 ]. Daverey and Agrawal revealed that curcumin treatment protected against spinal cord injury-induced white matter damage via NF- κ B and Nrf2 crosstalk [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF-κB Suppression and NLRP3 Inflammasome Inhibition

Ran

Gao

et al. 2021

Oxidative Medicine and Cellular Longevity

108

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NLRP3 inflammasome-mediated pyroptosis is a proinflammatory programmed cell death pathway, which plays a vital role in functional outcomes after stroke. We previously described the beneficial effects of curcumin against stroke-induced neuronal damage through modulating microglial polarization. However, the impact of curcumin on microglial pyroptosis remains unknown. Here, stroke was modeled in mice by middle cerebral artery occlusion (MCAO) for 60 minutes and treated with curcumin (150 mg/kg) intraperitoneally immediately after reperfusion, followed by daily administrations for 7 days. Curcumin ameliorated white matter (WM) lesions and brain tissue loss 21 days poststroke and improved sensorimotor function 3, 10, and 21 days after stroke. Furthermore, curcumin significantly reduced the number of gasdermin D+ (GSDMD+) Iba1+ and caspase-1+Iba1+ microglia/macrophage 21 days after stroke. In vitro, lipopolysaccharide (LPS) with ATP treatment was used to induce pyroptosis in primary microglia. Western blot revealed a decrease in pyroptosis-related proteins, e.g., GSDMD-N, cleaved caspase-1, NLRP3, IL-1β, and IL-18, following in vitro or in vivo curcumin treatment. Mechanistically, both in vivo and in vitro studies confirmed that curcumin inhibited the activation of the NF-κB pathway. NLRP3 knocked down by siRNA transfection markedly increased the inhibitory effects of curcumin on microglial pyroptosis and proinflammatory responses, both in vitro and in vivo. Furthermore, stereotaxic microinjection of AAV-based NLRP3 shRNA significantly improved sensorimotor function and reduced WM lesion following curcumin treatment in MCAO mice. Our study suggested that curcumin reduced stroke-induced WM damage, improved functional outcomes, and attenuated microglial pyroptosis, at least partially, through suppression of the NF-κB/NLRP3 signaling pathway, further supporting curcumin as a potential therapeutic drug for stroke.

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Section: Discussionmentioning

confidence: 99%

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF-κB Suppression and NLRP3 Inflammasome Inhibition

Ran

Gao

et al. 2021

Oxidative Medicine and Cellular Longevity

108

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“…As noted above, increasing the number of arms from 8 to 12 may increase the demand for spatial working memory (Sabolek et al, 2004). Longitudinal studies in monkeys indicate that the decline in working memory capacity, is highly variable and in some cases, the influence of practice effects cannot be ruled out (Moss, 1993;Koo et al, 2018;Ibanez et al, 2019).…”

Section: Span Taskmentioning

confidence: 98%

Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

McQuail

Dunn

Stern

et al. 2021

Front. Aging Neurosci.

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The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forthcoming longitudinal studies will build upon a wealth of knowledge gleaned from prior cross-sectional designs to identify early predictors of variability in cognitive function during aging, and characterize fundamental neurobiological mechanisms that underlie the vulnerability to, and the trajectory of, cognitive decline. Finally, we present examples of biological measures that may differentiate mechanisms of the cognitive reserve at the molecular, cellular, and network level.

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“…One solid-lipid curcumin preparation (SLCP), Longvida©, has been used in several preclinical and clinical trials. Primate studies indicate that Longvida© can protect against age-related cognitive decline [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study

et al. 2020

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Curcumin (a flavonoid isolated from turmeric) affects several processes involved in neurocognitive aging. We have previously reported that short term (4-weeks) administration of a highly bioavailable curcumin preparation (Longvida©) improved working memory and reduced fatigue and stress reactivity in a healthy older cohort. The present trial (ACTRN12616000484448) was a partial replication study, evaluating similar effects at 4 and 12-weeks Longvida© supplementation. A double-blind, placebo-controlled, parallel-groups trial was conducted. Eighty participants aged 50–80 years (mean = 68.1, SD = 6.34) were randomised to receive Longvida© (400 mg daily containing 80 mg curcumin) or a matching placebo. Assessment took place at baseline then following 4 and 12 weeks treatment. Outcome measures included cognitive performance, mood and biomarkers. Compared with placebo, curcumin was associated with several significant effects. These included better working memory performance at 12-weeks (Serial Threes, Serial Sevens and performance on a virtual Morris Water Maze), and lower fatigue scores on the Profile of Mood States (POMS) at both 4 and 12-weeks, and of tension, anger, confusion and total mood disturbance at 4-weeks only. The curcumin group had significantly elevated blood glucose. These results confirm that Longvida© improves aspects of mood and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations.

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Long-term effects of curcumin in the non-human primate brain

Cited by 12 publications

References 79 publications

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF-κB Suppression and NLRP3 Inflammasome Inhibition

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF-κB Suppression and NLRP3 Inflammasome Inhibition

Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study

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