Long-Term Effects of Chemotherapy on Dental Status in Children Treated for Nephroblastoma

Abstract

Dental abnormalities among children treated at a young age for Wilms tumor are reported. The authors retrospectively reviewed the dental records and panoramic radiographs of 27 children treated for nephroblastoma between 1994 and 1998. They evaluated the frequency of apparent microdontia, excessive caries, root stunting, hypodontia, and enamel hypoplasia and compared this group to a control group of 78 children. Seventy percent of the children developed dental abnormalities, comprising root stunting (44%), enamel hypoplasia (22%), microdontia (18%), and hypodontia (7%). Results of control subjects were significantly different regarding dental abnormalities, especially microdontia and taurodontia. These results indicate that chemotherapy in children may lead to troubles affecting teeth growing at the time of treatment. Information and prospective dental care are needed, and further investigations are required.

Investigation of orofacial stem cell niches and their innervation through microfluidic devices

“…Beyond these genetic conditions, tooth loss can be caused by common dental diseases such as periodontitis and severe carious lesions, injuries, age-related alterations, and cancer (Marec-Berard et al, 2005;Matalova et al, 2008;Mitsiadis and Harada, 2015;Mitsiadis and Papagerakis, 2011). For example, in the case of oral squamous cell carcinomas, treatment involves radiotherapy, surgery and chemotherapy.…”

“…Oral cancers and their treatments often affect the structure and physiological function of more than one orofacial tissues and organs. In particular, radiotherapy and chemotherapy strongly affect salivary gland function, resulting in severe swallowing problems, dental caries and tooth loss (Cooper et al, 1995;Langendijk et al, 2008;Marec-Berard et al, 2005;Matalova et al, 2008;Minicucci et al, 2003).…”

“…Oral cancers and their treatments often affect the structure and physiological function of more than one orofacial tissues and organs. In particular, radiotherapy and chemotherapy strongly affect salivary gland function, resulting in severe swallowing problems, dental caries and tooth loss (Cooper et al, 1995;Langendijk et al, 2008;Marec-Berard et al, 2005;Matalova et al, 2008; Minicucci et al, 2003).All these conditions mentioned above affect tooth functionality. Treatment options for patients with tooth agenesis, pathological tooth loss, AI, and other serious defects of dental tissues are based on a constantly increased number of dental biomaterials.…”

“…In a strict sense, the definition of AI includes only enamel dysplasias, which occur in the absence of defects in other tissues, and can be phenotypically classified into three different types. The hypoplastic type of AI is characterised by a thinner layer of enamel, the hypomaturated form by a rather soft enamel, and the hypocalcified type by an extremely soft enamel that wears quickly after tooth eruption (Crawford et al, 2007).Beyond these genetic conditions, tooth loss can be caused by common dental diseases such as periodontitis and severe carious lesions, injuries, age-related alterations, and cancer (Marec-Berard et al, 2005;Matalova et al, 2008;Mitsiadis and Harada, 2015;Mitsiadis and Papagerakis, 2011). For example, in the case of oral squamous cell carcinomas, treatment involves radiotherapy, surgery and chemotherapy.…”

Tooth sizes in nonsyndromic hypodontia patients

“…It might be the result of either environmental or genetic factors, or a combination of these. [13][14][15][16][17][18][19][20][21][22][23][24][25] One of the determinants of successful orthodontic treatment with perfect occlusion is harmonious tooth size. Tooth size in relation to the mandibular and maxillary arches determines whether the dentition is spaced or crowded, and discrepancies in the sizes of teeth in different arches determine buccal interdigitation, overjet, overbite, and center line discrepancies.…”