Long-Term Effects of Acoustic Trauma on Electrically Evoked Otoacoustic Emission

Hälsey, Karin; Fegelman, Karen J. L.; Raphael, Yehoash; Grosh, Karl; Dolan, David F.

doi:10.1007/s10162-005-0011-x

Cited by 5 publications

(8 citation statements)

References 41 publications

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“…While the exact site from which the movements originated was not assessed in this study, the most likely source of force generation would be from outer hair cells (Halsey et al 2005;Liberman et al 2004). Force generation by outer hair cell somatic electromotility and/or stereociliary motility within the normal organ of Corti in response to electrical stimuli is called reverse transduction, and these processes have been postulated to underlie the cochlear amplifier (Fettiplace and Hackney 2006).…”

Section: Reverse Transduction In the Mutant Mousementioning

confidence: 94%

Altered Traveling Wave Propagation and Reduced Endocochlear Potential Associated with Cochlear Dysplasia in the BETA2/NeuroD1 Null Mouse

Xia

Visosky

Cho

et al. 2007

JARO

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The BETA2/NeuroD1 null mouse has cochlear dysplasia. Its cochlear duct is shorter than normal, there is a lack of spiral ganglion neurons, and there is hair cell disorganization. We measured vertical movements of the tectorial membrane at acoustic frequencies in excised cochleae in response to mechanical stimulation of the stapes using laser doppler vibrometry. While tuning curve sharpness was similar between wild-type, heterozygotes, and null mice in the base, null mutants had broader tuning in the apex. At both the base and the apex, null mice had less phase lag accumulation with increasing stimulus frequency than wild-type or heterozygote mice. In vivo studies demonstrated that the null mouse lacked distortion product otoacoustic emissions, and the cochlear microphonic and endocochlear potential were found to be severely reduced. Electrically evoked otoacoustic emissions could be elicited, although the amplitudes were lower than those of wild-type mice. Cochlear cross-sections revealed an incomplete partition malformation, with fenestrations within the modiolus that connected the cochlear turns. Outer hair cells from null mice demonstrated the normal pattern of prestin expression within their lateral walls and normal FM 1-43 dye entry.Overall, these data demonstrate that while tonotopicity can exist with cochlear dysplasia, traveling wave propagation is abnormally fast. Additionally, the presence of electrically evoked otoacoustic emissions suggests that outer hair cell reverse transduction is present, although the acoustic response is shaped by the alterations in cochlear mechanics.

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Section: Reverse Transduction In the Mutant Mousementioning

confidence: 94%

Altered Traveling Wave Propagation and Reduced Endocochlear Potential Associated with Cochlear Dysplasia in the BETA2/NeuroD1 Null Mouse

Xia

Visosky

Cho

et al. 2007

JARO

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“…To estimate the delay components of the EEOAEs, we used a multicomponent analysis (MCA) as developed by and applied by Halsey et al (2005). In Fig.…”

Section: Multicomponent Analysismentioning

confidence: 99%

“…On reaching its CF place, the wave is regenerated through the action of the cochlear amplifier before traveling back to the ear canal . and Halsey et al (2005) showed the SDC of EEOAEs to be extremely robust, surviving almost complete elimination of the hair cells. The LDC, however, is more vulnerable and seems to better reflect the physiological state of the cochlea (Halsey et al 2005).…”

Section: Introductionmentioning

confidence: 98%

The Role of Prestin in the Generation of Electrically Evoked Otoacoustic Emissions in Mice

Drexl¹,

Lagarde²,

Zuo³

et al. 2008

Journal of Neurophysiology

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Electrically evoked otoacoustic emissions are sounds emitted from the inner ear when alternating current is injected into the cochlea. Their temporal structure consists of short- and long-delay components and they have been attributed to the motile responses of the sensory-motor outer hair cells of the cochlea. The nature of these motile responses is unresolved and may depend on either somatic motility, hair bundle motility, or both. The short-delay component persists after almost complete elimination of outer hair cells. Outer hair cells are thus not the sole generators of electrically evoked otoacoustic emissions. We used prestin knockout mice, in which the motor protein prestin is absent from the lateral walls of outer hair cells, and Tecta(Delta ENT/Delta ENT) mice, in which the tectorial membrane, a structure with which the hair bundles of outer hair cells normally interact, is vestigial and completely detached from the organ of Corti. The amplitudes and delay spectra of electrically evoked otoacoustic emissions from Tecta(Delta ENT/Delta ENT) and Tecta(+/+) mice are very similar. In comparison with prestin(+/+) mice, however, the short-delay component of the emission in prestin(-/-) mice is dramatically reduced and the long-delay component is completely absent. Emissions are completely suppressed in wild-type and Tecta(Delta ENT/Delta ENT) mice at low stimulus levels, when prestin-based motility is blocked by salicylate. We conclude that near threshold, the emissions are generated by prestin-based somatic motility.

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“…Stimulation frequency was fine tuned such that the emission frequency was 5.6, 8, 11.2, or 16 kHz, and emission frequency and amplitude were determined using a lock-in-amplifier ͑SR530; Stanford Research Systems͒. For the ninth animal, current remained fixed between 0 ͑noise floor͒ and 30 A; however, stimulation frequency ͑controlled by an SRS 830 lock-in amplifier͒ was stepped from 1 to 35 kHz in 22 Hz increments ͑1 s dwell time per frequency increment͒, with a time constant of 3 s ͑as described by Halsey et al, 2006͒. Development of the latter procedure significantly improved frequency resolution for measuring the EEOAE response.…”

Section: E Electrically Evoked Otoacoustic Emission Assessmentmentioning

confidence: 99%

Electromotile hearing: Acoustic tones mask psychophysical response to high-frequency electrical stimulation of intact guinea pig cochle

Prell¹,

Kawamoto²,

Raphael³

et al. 2006

The Journal of the Acoustical Society of America

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When sinusoidal electric stimulation is applied to the intact cochlea, a frequency-specific acoustic emission can be recorded in the ear canal. Acoustic emissions are produced by basilar membrane motion, and have been used to suggest a corresponding acoustic sensation termed "electromotile hearing." Electromotile hearing has been specifically attributed to electric stimulation of outer hair cells in the intact organ of Corti. To determine the nature of the auditory perception produced by electric stimulation of a cochlea with intact outer hair cells, guinea pigs were tested in a psychophysical task. First, subjects were trained to report detection of sinusoidal acoustic stimuli and dynamic range was assessed using response latency. Subjects were then implanted with a ball electrode placed into scala tympani. Following the surgical implant procedure, subjects were transferred to a task in which acoustic signals were replaced by sinusoidal electric stimulation, and dynamic range was assessed again. Finally, the ability of acoustic pure-tone stimuli to mask the detection of the electric signals was assessed. Based on the masking effects, it is concluded that sinusoidal electric stimulation of the intact cochlea results in perception of a tonal (rather than a broadband or noisy) sound at a frequency of 8 kHz or above.

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Long-Term Effects of Acoustic Trauma on Electrically Evoked Otoacoustic Emission

Cited by 5 publications

References 41 publications

Altered Traveling Wave Propagation and Reduced Endocochlear Potential Associated with Cochlear Dysplasia in the BETA2/NeuroD1 Null Mouse

Altered Traveling Wave Propagation and Reduced Endocochlear Potential Associated with Cochlear Dysplasia in the BETA2/NeuroD1 Null Mouse

The Role of Prestin in the Generation of Electrically Evoked Otoacoustic Emissions in Mice

Electromotile hearing: Acoustic tones mask psychophysical response to high-frequency electrical stimulation of intact guinea pig cochle

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