Long-term effects of a three-component lifestyle intervention on emotional well-being in women with Polycystic Ovary Syndrome (PCOS): A secondary analysis of a randomized controlled trial

Abstract

Many women with Polycystic Ovary Syndrome (PCOS) report high depression rates. The relationship between PCOS and these high depression rates is unclear. Two-component lifestyle interventions have revealed short-term effects on depression scores in this group of women. In general, 3-component interventions including diet, exercise, and cognitive behavioral therapy (CBT) are more effective in the long-term to improve emotional wellbeing. This has not yet been studied in women with PCOS. This study examined the effect of 20 CBT lifestyle (LS) sessions combined with a healthy diet and physical therapy with or without 9 months additional feedback through Short Message Service (SMS) via mobile phone, compared to care as usual (CAU, involving advice to lose weight). In this secondary analysis, 155 women with PCOS and a BMI above 25 kg/m 2 were eligible. Depression scores decreased significantly in the LS programme compared to CAU (P = 0.045). In both the LS programme without SMS (P = 0.036) and the LS programme with SMS (P = 0.011) depression scores decreased while no change was observed in CAU (P = 0.875). Selfesteem scores improved significantly in the LS programme compared to CAU (P = 0.027). No differences in body image scores were observed in LS participants compared to CAU (P = 0.087), although body image improved significantly in both the LS without SMS (P = 0.001) and with SMS (P = 0.008) study arms. We found no significant mediating role by androgens in the relationship between LS participants and emotional well-being. Only weight-loss mediated the relationship between LS and self-esteem. To conclude, a threecomponent lifestyle intervention programme with or without additional SMS resulted in significant improvements in depression and self-esteem compared to CAU, in women with PCOS, obesity, and a wish to achieve a pregnancy. Testosterone, androstenedione, DHEA, insulin, HOMA-IR, and cortisol did not mediate this effect. Weight loss mediated the effects

Lifestyle and psychosocial risks among women with polycystic ovary syndrome and insulin resistance

“…Ponieważ zaburzenia występujące w ramach PCOS powodują wzrost napięcia psychogennego wśród kobiet, podejmowane są badania analizujące wpływ wsparcia społecznego oraz terapii wspierającej na dobrostan pacjentek [36,37,38,39]. Wykazano, że udzielenie wsparcia społecznego przekłada się na wzrost samooceny wśród badanych kobiet, a w dłuższym czasie na poprawę jakości ich życia [36,38,39].…”

“…Ponieważ zaburzenia występujące w ramach PCOS powodują wzrost napięcia psychogennego wśród kobiet, podejmowane są badania analizujące wpływ wsparcia społecznego oraz terapii wspierającej na dobrostan pacjentek [36,37,38,39]. Wykazano, że udzielenie wsparcia społecznego przekłada się na wzrost samooceny wśród badanych kobiet, a w dłuższym czasie na poprawę jakości ich życia [36,38,39]. Z kolei przynależność do samopomocowych grup wsparcia umożliwia pacjentkom wymianę doświadczeń, poczucie zrozumienia i akceptacji, ale stwarza również ryzyko nadmiernej koncentracji na opisywanych objawach choroby [37].…”

Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

“…Extensive clinical investigations indicate that dietary and lifestyle preferences can be associated with follicle growth and ovulation rates in women undergoing assisted reproduction technology (ART) [ 11 , 12 ]. Several patients suffer from infertility with no cause clearly identified, suggesting that emotional stress, environmental factors, and nutritional status may play a role on their reproductive function [ 13 , 14 ].…”

The effect of polycystic ovarian syndrome on the mental health of women of reproductive age

“…4,5 PCOS can also increase women's risk of type 2 diabetes, cardiovascular disease, infertility, anxiety and depression, and poor health-related quality of life. [6][7][8] The signs and symptoms usually develop in menarche and they vary from woman to woman. 9,10 These changes may be in response to obesity causing irregular or prolonged cycles with more than 35-day intervals.…”