Long-term effects of a single adult methamphetamine challenge: Minor impact on dopamine fibre density in limbic brain areas of gerbils

Brummelte, Susanne; Grund, Thorsten; Czok, Andrea; Teuchert-Noodt, Gertraud; Neddens, Joerg

doi:10.1186/1744-9081-2-12

Cited by 9 publications

(2 citation statements)

References 67 publications

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“…This is consistent with a recent report that a single injection of 25 mg/kg METH failed to decrease DA fiber density in limbic brain areas of adult gerbils (Brummelte et al, 2006). These data suggest that the present non-fatal METH doses may not produce severe damage to striatal DA terminals.…”

Section: Discussionsupporting

confidence: 94%

A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats

Kleitz

Deng

et al. 2009

Neuroscience

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Psychostimulant addicts often take high doses of drugs, and high doses of psychostimulants such as methamphetamine (METH) are neurotoxic to striatal dopamine (DA) terminals. Yet, the effects of high doses of METH on drug-seeking and drug-taking behavior have not been examined. In the present study, we found that single high doses of METH in rats (10–20 mg/kg) dose-dependently increased cocaine self-administration under fixed-ratio 2 (FR2) reinforcement conditions, while higher doses (40 mg/kg×1 or 10 mg/kg/2 h×4) caused high mortality among rats maintained on daily cocaine self-administration. The increased cocaine self-administration appeared to be a compensatory response to reduced cocaine reward after METH, because the same doses of METH caused a dose-dependent reduction both in “breakpoint” levels for cocaine self-administration under progressive-ratio reinforcement and in nucleus accumbens DA response to acute cocaine. Further, METH (10–20 mg/kg) produced large DA release (4000%–6000% over baseline), followed by a significant reduction in striatal DA and 3,4-dihydroxyphenylacetic acid (DOPAC) contents, but without significant changes in striatal DA transporter levels. These findings suggest that the present high doses of METH caused striatal DA depletion or hypofunction without severe damage in DA terminals, which may contribute to the increased cocaine-taking behavior observed in the present study. Provided that the present doses of METH may mimic METH overdose incidents in humans, the present findings suggest that METH-induced DA depletion or neurotoxicity may lead to an increase in subsequent drug-taking and drug-seeking behavior.

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Section: Discussionsupporting

confidence: 94%

A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats

Kleitz

Deng

et al. 2009

Neuroscience

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“…[5] This is important because variations in maternal care in rodents, independent of prenatal exposures, have been linked to altered offspring behavior and persistent changes in the offspring brain. [6] High-fat diet (HFD), [7][8][9] low-protein diet (LPD), [10] chronic psychological stress, [11] physical restraint, [12] chronic corticosterone administration, [13] and vitamin D deficiency [14] in pregnancy are just some of the stressors that have been reported to induce changes in maternal behavior in animal models. There is very little data on the consequences, specifically of HFD, in a human pregnancy on maternal care but maternal obesity is a well-known risk factor for maternal depression and anxiety, [15] and there are studies that link maternal obesity to lower quality maternal attachment [16] and maternal parenting stress.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Adversity Modulates the Quality of Maternal Care Via the Exposed Offspring

Roshan

2019

BioEssays

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Adversities in pregnancy, including poor diet and stress, are associated with increased risk of developing both metabolic and mental health disorders later in life, a phenomenon described as fetal programming or developmental origins of disease. Predominant hypotheses proposed to explain this relationship suggest that the adversity imposes direct changes to the developing fetus which are maintained after birth resulting in an increased susceptibility to ill health. However, during pregnancy the mother, the developing fetus, and the placenta are all exposed to the adversity. The same adversities linked to altered offspring outcome can also result in suboptimal maternal care, which is considered an independent adverse exposure for the offspring. Recent key experiments in mice reveal the potential of prenatal adversity to drive alterations in maternal care through abnormal maternal–pup interactions and via alterations in placental signaling. Together, these data highlight the critical importance of viewing fetal programming holistically paying attention to the intimate, bidirectional, and reiterative relationship between mothers and their offspring.

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Repeated neonatal separation stress alters the composition of neurochemically characterized interneuron subpopulations in the rodent dentate gyrus and basolateral amygdala

Seidel

Helmeke

Poeggel

et al. 2008

Developmental Neurobiology

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Emotional experience during early life has been shown to interfere with the development of excitatory synaptic networks in the prefrontal cortex, hippocampus, and the amygdala of rodents and primates. The aim of the present study was to investigate a developmental "homoeostatic synaptic plasticity" hypothesis and to test whether stress-induced changes of excitatory synaptic composition are counterbalanced by parallel changes of inhibitory synaptic networks. The impact of repeated early separation stress on the development of two GABAergic neuronal subpopulations was quantitatively analyzed in the brain of the semiprecocial rodent Octodon degus. Assuming that PARV- and CaBP-D28k-expression are negatively correlated to the level of inhibitory activity, the previously described reduced density of excitatory spine synapses in the dentate gyrus of stressed animals appears to be "amplified" by elevated GABAergic inhibition, reflected by reduced PARV- (down to 85%) and CaBP-D28k-immunoreactivity (down to 74%). In opposite direction, the previously observed elevated excitatory spine density in the CA1 region of stressed animals appears to be amplified by reduced inhibition, reflected by elevated CaPB-D28k-immunoreactivity (up to 149%). In the (baso)lateral amygdala, the previously described reduction of excitatory spine synapses appears to be "compensated" by reduced inhibitory activity, reflected by dramatically elevated PARV- (up to 395%) and CaPB-D28k-immunoreactivity (up to 327%). No significant differences were found in the central nucleus of the amygdala, the piriform, and somatosensory cortices and in the hypothalamic paraventricular nucleus. Thus during stress-evoked neuronal and synaptic reorganization, a homeostatic balance between excitation and inhibition is not maintained in all regions of the juvenile brain.

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Long-term effects of a single adult methamphetamine challenge: Minor impact on dopamine fibre density in limbic brain areas of gerbils

Abstract: Background: The aim of the study was to test long-term effects of (+)-methamphetamine (MA) on the dopamine (DA) innervation in limbo-cortical regions of adult gerbils, in order to understand better the repair and neuroplasticity in disturbed limbic networks.

Cited by 9 publications

References 67 publications

A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats

A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats

Prenatal Adversity Modulates the Quality of Maternal Care Via the Exposed Offspring

Repeated neonatal separation stress alters the composition of neurochemically characterized interneuron subpopulations in the rodent dentate gyrus and basolateral amygdala

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