Long-term effects of a lifestyle intervention and oral glucosamine sulphate in primary care on incident knee OA in overweight women

Vos, Bastiaan C. de; Landsmeer, M.L.; Middelkoop, Marienke van; Oei, Edwin H.G.; Krul, Marjolein; Bierma-Zeinstra, Sita M A; Runhaar, Jos

doi:10.1093/rheumatology/kex145

Cited by 28 publications

(21 citation statements)

References 29 publications

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“…The current results were not obtained from an effective intervention, but rather from the observational significant and clinically relevant associations between weight loss and clinical and structural OA development. 13,14 A limitation of our validation of the compartment-accumulated cavity score is that the score does not show to what extent the quantification corresponds to few larger lesions or multiple smaller lesions, or whether focal defects such as fibrillations or fissures contribute to the score. Therefore, further validation could be performed against more invasive scorings from optical coherence tomography 15 or from histopathology.…”

Section: Method Results and Discussionmentioning

confidence: 99%

Medial Cartilage Surface Integrity as a Surrogate Measure for Incident Radiographic Knee Osteoarthritis following Weight Changes

et al. 2019

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Section: Method Results and Discussionmentioning

confidence: 99%

Medial Cartilage Surface Integrity as a Surrogate Measure for Incident Radiographic Knee Osteoarthritis following Weight Changes

et al. 2019

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“…miR‐146a fl/+ mice have been backcrossed with WT (C57BL/6J) mice for over seven generations to maintain in a C57BL/6J background. Using the strategy described previously to achieve cartilage‐specific overexpression of miRNA (de Vos et al., 2017), they were bred with Col2a1‐Cre mice to generate miR‐146aTG mice Col2a1Cre;miR‐146a [B6.Cg‐Tg(Col2a1‐Cre;miR‐146afl]. Genomic DNA isolated from the tail was analyzed by PCR using the primers used for confirmation of proper homologous recombination and genotyping are listed in Table S1.…”

Section: Methodsmentioning

confidence: 99%

Evidence that miR‐146a attenuates aging‐ and trauma‐induced osteoarthritis by inhibiting Notch1, IL‐6, and IL‐1 mediated catabolism

Guan

Yang

et al. 2018

Aging Cell

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SummaryPrimary osteoarthritis (OA) is associated with aging, while post‐traumatic OA (PTOA) is associated with mechanical injury and inflammation. It is not clear whether the two types of osteoarthritis share common mechanisms. We found that miR‐146a, a microRNA‐associated with inflammation, is activated by cyclic load in the physiological range but suppressed by mechanical overload in human articular chondrocytes. Furthermore, miR‐146a expression is decreased in the OA lesions of human articular cartilage. To understand the role of miR‐146a in osteoarthritis, we systemically characterized mice in which miR‐146a is either deficient in whole body or overexpressed in chondrogenic cells specifically. miR‐146a‐deficient mice develop early onset of OA characterized by cartilage degeneration, synovitis, and osteophytes. Conversely, miR‐146a chondrogenic overexpressing mice are resistant to aging‐associated OA. Loss of miR‐146a exacerbates articular cartilage degeneration during PTOA, while chondrogenic overexpression of miR‐146a inhibits PTOA. Thus, miR‐146a inhibits both OA and PTOA in mice, suggesting a common protective mechanism initiated by miR‐146a. miR‐146a suppresses IL‐1β of catabolic factors, and we provide evidence that miR‐146a directly inhibits Notch1 expression. Therefore, such inhibition of Notch1 may explain suppression of inflammatory mediators by miR‐146a. Chondrogenic overexpression of miR‐146a or intra‐articular administration of a Notch1 inhibitor alleviates IL‐1β‐induced catabolism and rescues joint degeneration in miR‐146a‐deficient mice, suggesting that miR‐146a is sufficient to protect OA pathogenesis by inhibiting Notch signaling in the joint. Thus, miR‐146a may be used to counter both aging‐associated OA and mechanical injury‐/inflammation‐induced PTOA.

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“…GlcN is largely used for osteoarthritis at an average dose of 1,500 mg per day but its usefulness in other pathologies has not been explored in clinical trials. Whereas, long term treatment seems to delay the progression of knee arthritis (28), multiple studies have shown no superiority of glucosamine vs. placebo (89), no improvement of cartilage damage (90) and no role in prevention of osteoarthritis in overweight women (91). Moreover, at the usual doses, GlcN may induce an increase in intraocular pressure (92).…”

Section: Toward a Potential Clinical Applicationmentioning

confidence: 99%

Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, Future

et al. 2019

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O-GlcNAcylation is a ubiquitous and reversible post-translational protein modification that has recently gained renewed interest due to the rapid development of analytical tools and new molecules designed to specifically increase the level of protein O-GlcNAcylation. The level of O-GlcNAc modification appears to have either deleterious or beneficial effects, depending on the context (exposure time, pathophysiological context). While high O-GlcNAcylation levels are mostly reported in chronic diseases, the increase in O-GlcNAc level in acute stresses such as during ischemia reperfusion or hemorrhagic shock is reported to be beneficial in vitro, ex vivo, or in vivo. In this context, an increase in O-GlcNAc levels could be a potential new cardioprotective therapy, but the ambivalent effects of protein O-GlcNAcylation augmentation remains as a key problem to be solved prior to their transfer to the clinic. The emergence of new analytical tools has opened new avenues to decipher the mechanisms underlying the beneficial effects associated with an O-GlcNAc level increase. A better understanding of the exact roles of O-GlcNAc on protein function, targeting or stability will help to develop more targeted approaches. The aim of this review is to discuss the mechanisms and potential beneficial impact of O-GlcNAc modulation, and its potential as a new clinical target in cardiology.

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Long-term effects of a lifestyle intervention and oral glucosamine sulphate in primary care on incident knee OA in overweight women

Abstract: ISRTCN registry, http://www.isrctn.com , ISRCTN42823086.

Cited by 28 publications

References 29 publications

Medial Cartilage Surface Integrity as a Surrogate Measure for Incident Radiographic Knee Osteoarthritis following Weight Changes

Medial Cartilage Surface Integrity as a Surrogate Measure for Incident Radiographic Knee Osteoarthritis following Weight Changes

Evidence that miR‐146a attenuates aging‐ and trauma‐induced osteoarthritis by inhibiting Notch1, IL‐6, and IL‐1 mediated catabolism

Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, Future

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